Results 61 to 70 of about 154,979 (298)

What “Hides” Behind Sovereign Debt Ratings? [PDF]

In this paper we study the determinants of sovereign debt credit ratings using rating notations from the three main international rating agencies, for the period 1995-2005. We employ panel estimation and random effects ordered probit approaches to assess
António Afonso, Pedro Gomes, Philipp Rother   +2 more
core   +2 more sources

Brain Pericytes — Crucial Regulators of Neuroinflammation in Ischemic Stroke

Neuropharmacology and Therapy
Inflammation is a key element in the pathophysiology of ischemic stroke. The current effective treatments for ischemic stroke are almost exclusively based on reperfusion of occluded vessels.
Ziyi Chen, Qingsheng Li, Kaixin Wang, Lingfei Yang, Yanjie Jia, Zhe Gong   +5 more
doaj   +1 more source

Blood–Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control

Advanced Healthcare Materials, EarlyView.
Conventional therapies suffer from poor blood–brain barrier (BBB) penetration and disordered ion/reactive oxygen species (ROS) homeostasis, hindering precise neurological treatment. Electrochemical strategies achieve accurate spatiotemporal regulation of neural homeostasis.
Xiaokang Hu, Caiyu Liu, Meijun Pang, Zhiyuan Shi, Dong Ming, Xiuyun Liu   +5 more
wiley   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Ensemble Predictions for TDC BBB-Martins Leaderboard

, 2023
Ensemble predictions for a drugs ability to penetrate the blood brain barrier using Therapeutic Data Commons BBB-Martins dataset. Includes .tsv files with the actual and predicted classifications of BBB permeability for each drug in the TDC test set ...
Rick Fontenot (14855842)
core   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Subgroups and products of $\Bbb R$-factorizable $P$-groups

, 2004
summary:We show that {\it every\/} subgroup of an $\Bbb R$-factorizable abelian $P$-group is topologically isomorphic to a {\it closed\/} subgroup of another $\Bbb R$-factorizable abelian $P$-group.
Tkachenko, Michael, Hernández, Constancio   +1 more
core   +1 more source

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma. [PDF]

Adv Sci (Weinh)
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Paul AR, Mitchell AM, O'Neil D, Luo Y, Al-Jamal KT.   +4 more
europepmc   +2 more sources

Inhibition of RIPK1 activity retarded BBB leakage.

, 2023
(A). The measurement of permeability of the BBB in wild-type and Ripk1D138N mutant mice. (B). The quantifications of fluorescence intensity of p-RIPK1 and leaked IgG during CIRI.
Yongjiao Wang (2192470), Xiaohui Wu (228851), Min Gong (451173), Ying Li (38224), Chaonan Yang (16827898)   +4 more
core   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source