Results 111 to 120 of about 141,528 (311)

$\Omega_{bbb}\Omega_{bbb}\Omega_{bbb}$ tribaryons

We study the possible existence of bound states of three $\Omega_{bbb}$ baryons. We consider only $S$ wave interactions and we start from recent lattice QCD results which give a strongly attractive potential between two $\Omega_{bbb}$ baryons in the $^1S_0$ channel. We analyze different scenarios.
Garcilazo, H., Valcarce, A.
openaire   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

The number of subgroups of the group $\Bbb{Z}_m\times \Bbb{Z}_n \times \Bbb{Z}_r \times \Bbb{Z}_s$

, 2016
13 pages ...
openaire   +2 more sources

Volume of BBB opening per NHP and location.

, 2015
Table shows the BBB opening volume per target location, animal and pressure.Volume of BBB opening per NHP and location.
Amanda Buch (735757), Vincent P. Ferrera (347678), Matthew E. Downs (735756), Shangshang Chen (735760), Maria Eleni Karakatsani (735759), Carlos Sierra (735758), Elisa E. Konofagou (347680)   +6 more
core   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Human BBB-on-a-Chip using iPSCs Derived HBMECs

, 2019
Blood-Brain Barrier(BBB) is a diffusion barrier protecting our brain and central nervous system (CNS) by blocking the harmful substances crossing from blood to brain. Ironically, the BBB structure becomes a major obstacle for drug delivery to treat brain
Park, Tae-Eun, Kim, Junyoung, Cho, Yoon-Kyoung, Lee, Gi-Wook, Lee, Chaeeun   +4 more
core  

Counting subgroups of the groups ${\Bbb Z}_{n_1} \times \cdots \times {\Bbb Z}_{n_k}$: a survey

We present a survey of exact and asymptotic formulas on the number of cyclic subgroups and total number of subgroups of the groups ${\Bbb Z}_{n_1} \times \cdots \times {\Bbb Z}_{n_k}$, where $k\ge 2$ and $n_1,\ldots,n_k$ are arbitrary positive integers ...
Tóth, László
core   +2 more sources

Model for the response of the two BBB to ECM.

, 2012
A) The cerebral microvascular tree contains two functionally distinct BBB. The physiological BBB is formed by capillaries (diameter 4–8 µm) and consists of a single layer composed of endothelia, gliovascular membrane, and astrocyte endfeet.
Stefan H. I. Kappe (126797), Adela Nacer (5648602), Kerstin Baer (36290), Ute Frevert (113), Alexandru Movila (126795), Sebastian A. Mikolajczak (126796)   +5 more
core   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases

Fluids and Barriers of the CNS
Background Maintaining the structural and functional integrity of the blood–brain barrier (BBB) is vital for neuronal equilibrium and optimal brain function.
Tongli Chen, Yan Dai, Chenghao Hu, Zihao Lin, Shengzhe Wang, Jing Yang, Linghui Zeng, Shanshan Li, Weiyun Li   +8 more
doaj   +1 more source