Results 101 to 110 of about 116,733 (246)

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

Annals of Neurology, EarlyView.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff, David L. Bennett, Troels S. Jensen, Eva L. Feldman   +3 more
wiley   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

DETECTION OF LEVOCETIRIZINE INTERACTIONS WITH NSAIDS BY SPECTROPHOTOMETRIC TECHNIQUE

FUUAST Journal of Biology
Levocetirizine, a levorotatory enantiomer of anti-histamine cetirizine, available as hydrochloride and useful in the management of intermittent or persistent allergic rhinitis and hay fever.
SHAFAQUE MEHBOOB, KIRAN RAFIQUE, MEHWISH WAJDI, ASMA WAZIR, NEMAT NAZIR, MALEEHA FARRUKH, SHAGUFTA USMANI, KHWAJA ZAFAR AHMED, AURANGZEB KHAN   +8 more
doaj  

Hydrogel-based microfluidic model of the blood-brain barrier: progress and future perspectives

Fluids and Barriers of the CNS
The development of brain-targeted delivery systems is significantly hindered by the blood-brain barrier (BBB), which prevents drugs from effectively reaching therapeutic regions in the brain.
Fangyuan Guo, Jialin Chen, Lianyi Wang, Mengqian Li, Qinan Lv, Jun Wang, Weiyong Hong, Gensheng Yang   +7 more
doaj   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Mehrfarbige und lichtintensitätsabgeschwächte Reaktionen von Proteinhydrogelen durch Photoregulierte Vernetzungsdynamik

Angewandte Chemie, EarlyView.
In ein vollständig auf Proteinen basierendes Hydrogel wurden zwei orthogonale Photorezeptoren integriert, um die reversible Manipulation der Steifigkeit durch rotes/fernrotes Licht und den irreversiblen Gel‐Sol‐Übergang durch grünes Licht zu ermöglichen.
Saskia Frank, Seraphine V. Wegner
wiley   +1 more source

Multicolor and Attenuated Light Intensity Responses in Protein Hydrogels Arising from Photoregulated Crosslink Dynamics

Angewandte Chemie International Edition, EarlyView.
A fully protein‐based hydrogel integrated two orthogonal photoreceptors to enable reversible manipulation of stiffness with red/far‐red light and irreversible gel‐sol transitions with green light. Unexpectedly, high‐intensity red light results in attenuated stiffening and dark‐adaptation, arising from increased crosslinking dynamics in the ...
Saskia Frank, Seraphine V. Wegner
wiley   +1 more source

Blood-brain barrier disruption: a culprit of cognitive decline?

Fluids and Barriers of the CNS
Cognitive decline covers a broad spectrum of disorders, not only resulting from brain diseases but also from systemic diseases, which seriously influence the quality of life and life expectancy of patients. As a highly selective anatomical and functional
Ji Che, Yinying Sun, Yixu Deng, Jun Zhang   +3 more
doaj   +1 more source

Spectroscopic and In Silico Determination of the Structural and Antioxidant Properties of Essential Oils From Lavandula Species Cultivated in the Silivri Region of Istanbul

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Plants are important sources of bioactive compounds that contribute to nutrition, health maintenance, and disease prevention. In this study, the chemical composition and antioxidant potential of essential oils obtained from Lavandula angustifolia “Sevtopolis” and Lavandula × intermedia cultivated in the Silivri region of Istanbul were ...
Bilge Bicak, Beray Kizilkaya, Serda Kecel Gunduz, Aliye Demet Demirag, Sabriye Percin Ozkorucuklu   +4 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source