Results 111 to 120 of about 153,854 (301)

Caveolar transport at BBB [PDF]

, 2020
The blood-brain barrier (BBB) tightly regulates substance and cell exchange between neural tissue and the systemic environment. For its full functionality, cerebral blood vessels rely on a network of endothelial and mural cells, referred to as ...
Chang, Jui-Hsien
core   +3 more sources

TITAN-BBB: Predicting BBB Permeability using Multi-Modal Deep-Learning Models

Computational prediction of blood-brain barrier (BBB) permeability has emerged as a vital alternative to traditional experimental assays, which are often resource-intensive and lowthroughput to meet the demands of early-stage drug discovery.
Saeed, Fahad, de Oliveira, Gabriel Bianchin   +1 more
core   +1 more source

Permeability of the BBB.

, 2013
A) Quantification of BBB extravasation of Evans blue (EB) in old mice ...
Jamie N. Mayo (586592), Shawn E. Bearden (586595), Richard S. Beard Jr (586593), Cheng-Hung Chen (586594), Bryce C. Rhodehouse (586591)   +4 more
core   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases

Fluids and Barriers of the CNS
Background Maintaining the structural and functional integrity of the blood–brain barrier (BBB) is vital for neuronal equilibrium and optimal brain function.
Tongli Chen, Yan Dai, Chenghao Hu, Zihao Lin, Shengzhe Wang, Jing Yang, Linghui Zeng, Shanshan Li, Weiyun Li   +8 more
doaj   +1 more source

Human blood–brain barrier spheroid models for the evaluation of drugs targeting brain vascular inflammation

Journal of Pharmacological Sciences
The blood–brain barrier (BBB), primarily formed by brain microvascular endothelial cells (BMECs), restricts substance entry into the brain. BBB inflammation, involving barrier dysfunction and immune cell recruitment, contributes to neurological diseases ...
Ayuka Ebisawa, Hanae Morio, Asuka Minasato, Hiromu Watanabe, Furano Kunitomo, Aleksandra Rutkowska, Tomomi Furihata   +6 more
doaj   +1 more source

Surgery on $\widetilde{\Bbb{SL}}\times\Bbb{E}^n$-manifolds

, 2004
7 pages, AMS-LaTeX file, To appear in the Canadian Mathematical Bulletin.
Hillman, J. A., Roushon, S. K.
openaire   +2 more sources

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Investigating nanoparticle interactions with the human blood-brain barrier in vitro [PDF]

BIO Web of Conferences
Sahin Hakan, Yucel Oguz, Holloway Paul, Yildirim Eren, Emik Serkan, Gurdag Gulten, Tanriverdi Gamze, Senturk Gozde Erkanli   +7 more
doaj   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source