Results 21 to 30 of about 116,733 (246)

review on the role of nanoparticles for targeted brain drug delivery

EXCLI Journal : Experimental and Clinical Sciences
Unfortunately, nowadays, brain disorders, which include both neurological and mental disorders, are the main cause of years spent living with a disability worldwide. There are serious diseases with a high prevalence and a high mortality rate.
Payam Nawzad Mohammed, Narmin Hamaamin Hussen, Aso Hameed Hasan, Hozan Jaza Hama Salh, Joazaizulfazli Jamalis, Sumeer Ahmed, Ajmal R. Bhat, Mohammad Amjad Kamal   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Revisiting strategies to target ABC transporter-mediated drug resistance in CNS cancer

Cancer Biology & Medicine
A significant number of anticancer drugs fail to treat primary and metastatic brain tumors primarily because of the complex blood-brain barrier (BBB) and overexpression of ATP-binding cassette (ABC) transporters, which decrease drug penetration into the ...
Haneen Amawi, Alaa M. Hammad, F. Scott Hall, Noor Hussein, Aseel O. Rataan, Abeer Mrayyan, Taqwa Al-kofahi, Ali Hmedat, Charles R. Ashby, Amit K. Tiwari   +9 more
doaj   +1 more source

Dynamic Interleukin-1 Receptor Type 1 Signaling Mediates Microglia-Vasculature Interactions Following Repeated Systemic LPS

Journal of Inflammation Research, 2022
Daniel P Nemeth,1– 3 Xiaoyu Liu,3 Daniel B McKim,4 Damon J DiSabato,2,5 Braedan Oliver,2 Anu Herd,3 Asish Katta,1 Christina E Negray,1,2 James Floyd,3 Samantha McGovern,3 Paige S Pruden,2 Feiyang Zhutang,2 Maria Smirnova,3 Jonathan P Godbout,2,5 John ...
Nemeth DP, Liu X, McKim DB, DiSabato DJ, Oliver B, Herd A, Katta A, Negray CE, Floyd J, McGovern S, Pruden PS, Zhutang F, Smirnova M, Godbout JP, Sheridan JF, Quan N   +15 more
doaj  

Treatment with penicillin G and hydrocortisone reduces ALS-associated symptoms: a case series of three patients [version 1; referees: 2 approved]

F1000Research, 2017
Three male Caucasian patients with ALS were admitted to the hospital due to progressive dysphagia and dysarthria. During two 21-day courses of penicillin G and hydrocortisone, these patients’ dysphagia and dysarthria resolved.
Bert Tuk, Harmen Jousma, Pieter J. Gaillard   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Synergistic Inhibition Between Bisbenzimidazole Derivative and Chloride Ion on Mild Steel in 0.25 M H2SO4 Solution

International Journal of Electrochemical Science, 2013
The inhibition of single 1, 4-bis (benzimidazolyl) butane (BBB) and the mixture of BBB and 0.1 M NaCl on the corrosion of mild steel in 0.25 M H2SO4 solution was studied using weight loss and electrochemical methods.
Xiumei Wang, Ye Wan, Qing Wang, Fangxiao Shi, Zhaorong Fan, Yanwen Chen   +5 more
doaj   +1 more source

Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier

Advanced Science, 2021
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from entering the brain.
Jia Li, Meng Zheng, Olga Shimoni, William A. Banks, Ashley I. Bush, Jennifer R. Gamble, Bingyang Shi   +6 more
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source