Results 81 to 90 of about 116,733 (246)

BBB-conquering antibodies [PDF]

Science-Business eXchange, 2014
Roche has developed an improved transferrin receptor–targeting strategy that dramatically increases delivery of biologics to the brain. The team showed proof of concept in mice and now needs to adapt the system for primate brains.
openaire   +1 more source

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source

Blood-Nanoparticle Interactions Create a Brain Delivery Superhighway for Doxorubicin

International Journal of Nanomedicine
Zhuoxuan Li,1 Tatyana Kovshova,2 Julia Malinovskaya,2 Julian Knoll,1 Saeed Shanehsazzadeh,1 Nadezhda Osipova,2 Anastasia Chernysheva,3 Pavel Melnikov,2 Svetlana Gelperina,2 Matthias G Wacker1 1National University of Singapore, Department of Pharmacy and ...
Li Z, Kovshova T, Malinovskaya J, Knoll J, Shanehsazzadeh S, Osipova N, Chernysheva A, Melnikov P, Gelperina S, Wacker MG   +9 more
doaj  

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

$\Omega_{bbb}\Omega_{bbb}\Omega_{bbb}$ tribaryons

We study the possible existence of bound states of three $\Omega_{bbb}$ baryons. We consider only $S$ wave interactions and we start from recent lattice QCD results which give a strongly attractive potential between two $\Omega_{bbb}$ baryons in the $^1S_0$ channel. We analyze different scenarios.
Garcilazo, H., Valcarce, A.
openaire   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

The number of subgroups of the group $\Bbb{Z}_m\times \Bbb{Z}_n \times \Bbb{Z}_r \times \Bbb{Z}_s$

, 2016
13 pages ...
openaire   +2 more sources

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases

Fluids and Barriers of the CNS
Background Maintaining the structural and functional integrity of the blood–brain barrier (BBB) is vital for neuronal equilibrium and optimal brain function.
Tongli Chen, Yan Dai, Chenghao Hu, Zihao Lin, Shengzhe Wang, Jing Yang, Linghui Zeng, Shanshan Li, Weiyun Li   +8 more
doaj   +1 more source