Results 31 to 40 of about 154,979 (298)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway

Open Medicine
Paraquat (PQ) is a frequently used herbicide with neurotoxic effects after acute or chronic exposure. Although in vitro evidence supports the PQ toxicity to dopamine cells, its in vivo effects (especially the chronic exposure) remain ambiguous.
Liu Tao, Zheng Fenshuang, Liu Lin, Zhou Hua, Shen Tao, Li Yanping, Zhang Wei   +6 more
doaj   +1 more source

review on the role of nanoparticles for targeted brain drug delivery

EXCLI Journal : Experimental and Clinical Sciences
Unfortunately, nowadays, brain disorders, which include both neurological and mental disorders, are the main cause of years spent living with a disability worldwide. There are serious diseases with a high prevalence and a high mortality rate.
Payam Nawzad Mohammed, Narmin Hamaamin Hussen, Aso Hameed Hasan, Hozan Jaza Hama Salh, Joazaizulfazli Jamalis, Sumeer Ahmed, Ajmal R. Bhat, Mohammad Amjad Kamal   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Revisiting strategies to target ABC transporter-mediated drug resistance in CNS cancer

Cancer Biology & Medicine
A significant number of anticancer drugs fail to treat primary and metastatic brain tumors primarily because of the complex blood-brain barrier (BBB) and overexpression of ATP-binding cassette (ABC) transporters, which decrease drug penetration into the ...
Haneen Amawi, Alaa M. Hammad, F. Scott Hall, Noor Hussein, Aseel O. Rataan, Abeer Mrayyan, Taqwa Al-kofahi, Ali Hmedat, Charles R. Ashby, Amit K. Tiwari   +9 more
doaj   +1 more source

The prevalence and factors associated for anti-tuberculosis treatment non-adherence among pulmonary tuberculosis patients in public health care facilities in South Ethiopia: a cross-sectional study

BMC Public Health, 2017
Background Evidence exists pointing out how non-adherence to treatment remains a major hurdle to efficient tuberculosis control in developing countries.
Tadele Teshome Woimo, Wondwossen Kassahun Yimer, Temesgen Bati, Hailay Abrha Gesesew   +3 more
doaj   +1 more source

Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier

Advanced Science, 2021
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from entering the brain.
Jia Li, Meng Zheng, Olga Shimoni, William A. Banks, Ashley I. Bush, Jennifer R. Gamble, Bingyang Shi   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Design, optimization and evaluation of an ion-triggered in situ nasal gel of selegiline for antidepressant therapy

Journal of Applied Pharmaceutical Research
Background: Oral delivery of selegiline is limited by extensive first-pass metabolism, low and variable bioavailability, and restricted brain access due to the blood–brain barrier.
Antesh Kumar Jha, Shiv Kumar Srivastava, Mahesh Prasad, Shashi Shankar, Abhishek Kumar Singh   +4 more
doaj   +1 more source

Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion

Fluids and Barriers of the CNS, 2021
Background Chronic cerebral hypoperfusion (CCH) is the leading cause of cerebral small vessel disease (CSVD). CCH is strongly associated with blood–brain barrier (BBB) dysfunction and white matter lesions (WMLs) in CSVD.
Zhengyu Sun, Chenhao Gao, Dandan Gao, Ruihua Sun, Wei Li, Fengyu Wang, Yanliang Wang, Huixia Cao, Guoyu Zhou, Jiewen Zhang, Junkui Shang   +10 more
doaj   +1 more source