Results 141 to 150 of about 43,134 (252)
Advanced Science, EarlyView.In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang +11 more
wiley +1 more source
Advanced Science, EarlyView.Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren +11 more
wiley +1 more source
Background/Objectives: Blood–brain barrier (BBB) permeability is a major practical obstacle in central nervous system (CNS) drug discovery, because only a small fraction of drug-like molecules achieve sufficient brain exposure.
Haiqiang Wu +3 more
core +1 more source
Volume of BBB opening per NHP and location.
, 2015 Table shows the BBB opening volume per target location, animal and pressure.Volume of BBB opening per NHP and location.
Amanda Buch (735757) +6 more
core +1 more source
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
Advanced Science, EarlyView.A multiscale computational framework links single‐nanoparticle magnetoelectric behavior to tissue‐level electric field distributions, integrating experimental data from nanoparticle characterization and in vitro stimulation setups. Applied to a cortical slice configuration, the framework predicts optimal MENP concentrations and stimulation parameters ...
Marta Bonato +10 more
wiley +1 more source
DETECTION OF LEVOCETIRIZINE INTERACTIONS WITH NSAIDS BY SPECTROPHOTOMETRIC TECHNIQUE
FUUAST Journal of BiologyLevocetirizine, a levorotatory enantiomer of anti-histamine cetirizine, available as hydrochloride and useful in the management of intermittent or persistent allergic rhinitis and hay fever.
SHAFAQUE MEHBOOB +8 more
doaj
Hydrogel-based microfluidic model of the blood-brain barrier: progress and future perspectives
Fluids and Barriers of the CNSThe development of brain-targeted delivery systems is significantly hindered by the blood-brain barrier (BBB), which prevents drugs from effectively reaching therapeutic regions in the brain.
Fangyuan Guo +7 more
doaj +1 more source
Proceedings of the National Academy of Sciences, 2022 Pearson, Caroline A. +1 more
openaire +2 more sources
Advanced Science, EarlyView.Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin +7 more
wiley +1 more source