Results 211 to 220 of about 116,953 (266)

Aumolertinib Versus Osimertinib as First‐Line Treatment for EGFR‐Mutant Non‐Small Cell Lung Cancer: A Retrospective Real‐World Multicenter Study

International Journal of Cancer, EarlyView.
As third‐generation EGFR‐tyrosine kinase inhibitors, both aumolertinib and osimertinib demonstrate clinical efficacy for non‐small cell lung adenocarcinoma, especially in patients with brain metastases. Currently, head‐to‐head studies comparing these two agents in real‐world settings are scarce.
Jinxia Wang, Ping Qi, Jinhua Li, Na Wang, Caihong Fu, Lixin Liu, Shuping Li, Xiao Li, Xiaoming Hou, Hui Qiao   +9 more
wiley   +1 more source

Exendin-4 protects brain endothelial cell damage against hyperammonemic condition. [PDF]

Biochem Biophys Rep
Ahn SY, Jo D, Choi SY, Song J.
europepmc   +1 more source

Developing a Z‐ESG Score Model for Assessing Corporate ESG Performance

International Journal of Finance &Economics, EarlyView.
ABSTRACT In this study we develop a novel, unique ESG rating model that exploits the logic of the Z‐score by Altman (1968) to discriminate between ESG performing and non‐ESG performing firms using indicators of ESG performance for each of the three pillars (Environmental, Social, Governance) in place of financial ratios.
Edward I. Altman, Francesco Baldi, Claudia D'Ippolito, Antonio Salvi   +3 more
wiley   +1 more source

Nanotechnology-Driven Drug-Delivery Systems: Mechanistic Insights for Pediatric Autism Treatment in 2026. [PDF]

Int J Nanomedicine
Atashgahi M, Madani F, Webster TJ.
europepmc   +1 more source

Regulatory Effects of Ammonium Chloride in an In Vitro Model of Hepatic Encephalopathy: Mechanisms Involving ACTA2‐Mediated Cytoskeletal Remodeling

iLABMED, EarlyView.
Hyperammonemic stress suppresses ACTA2 expression and induces F‐actin cytoskeletal remodeling in astrocytes. The resulting inhibition of FAK/c‐Src signaling contributes to apoptosis, G2/M arrest, AQP4‐mediated swelling and junction‐associated proteins dysregulation, revealing a central role for ACTA2‐dependent cytoskeletal dysfunction in hepatic ...
Yue Tang, Jia Liu, Chengrong Bian, Wenwen Yuan, Wang Zhang, Fan Feng, Boan Li   +6 more
wiley   +1 more source

Co-expression of MARCKS and GSDMD pathway genes in tuberculous meningitis: a multi-omics analysis of blood-brain barrier disruption. [PDF]

Front Cell Infect Microbiol
Luan M, Chen X, Lu Y.
europepmc   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, EarlyView.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

Ruxolitinib Penetrates Blood Brain Barrier and Reduces the Cytokine Storm in Patients With Haemophagocytic Lymphohistiocytosis. [PDF]

J Cell Mol Med
Ji W, Qing K, Ren J, Xue K, Fang J, Wu S.   +5 more
europepmc   +1 more source

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Splittings of $\tilde{\Bbb Q} / \Bbb Q$

Archiv der Mathematik, 2000
We prove that if K is a subextension of \(\tilde{\Bbb Q} / \Bbb Q\) which is PAC over \(\Bbb Q \), then the extension \(\tilde{\Bbb Q} / \Bbb Q\)splits through K, i.e., there is a field \(L\subseteq \tilde{\Bbb Q}\) linearly disjoint from K over \(\Bbb Q \) such that \(KL=\tilde{\Bbb Q}\).
openaire   +1 more source