Results 101 to 110 of about 43,134 (252)

Key epigenetic and signaling factors in the formation and maintenance of the blood-brain barrier

eLife
The blood-brain barrier (BBB) controls the movement of molecules into and out of the central nervous system (CNS). Since a functional BBB forms by mouse embryonic day E15.5, we reasoned that gene cohorts expressed in CNS endothelial cells (EC) at E13.5 ...
Jayanarayanan Sadanandan, Sithara Thomas, Iny Elizabeth Mathew, Zhen Huang, Spiros L Blackburn, Nitin Tandon, Hrishikesh Lokhande, Pierre D McCrea, Emery H Bresnick, Pramod K Dash, Devin W McBride, Arif Harmanci, Lalit K Ahirwar, Dania Jose, Ari C Dienel, Hussein A Zeineddine, Sungha Hong, Peeyush Kumar T   +17 more
doaj   +1 more source

BBB-conquering antibodies [PDF]

Science-Business eXchange, 2014
Roche has developed an improved transferrin receptor–targeting strategy that dramatically increases delivery of biologics to the brain. The team showed proof of concept in mice and now needs to adapt the system for primate brains.
openaire   +1 more source

Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro [PDF]

, 2013
Reproducing the characteristics and the functional responses of the blood–brain barrier (BBB) in vitro represents an important task for the research community, and would be a critical biotechnological breakthrough.
Eleanna Papa (441409), Rudini, Noemi, B. Engelhardt, Papa, Eleanna, E. Papa, M. Corada, Kavi Devraj, Pierre Olivier Couraud (383879), Couraud, Pierre Olivier, Luca Ferrarini, Monica Corada, Roberta Paolinelli, Pierre Olivier Couraud, K. Devraj, Luigi Maddaluno (441408), Cathrin J Czupalla, Engelhardt, Britta, Britta Engelhardt, Stefan Liebner (307398), R. Paolinelli, Noemi Rudini (441407), C. J. Czupalla, Cédric Artus, Luca Ferrarini (441403), E. Dejana, Elisabetta Dejana, C. Artus, Roberta Paolinelli (237864), Ferrarini, Luca, Devraj, Kavi, Dejana, Elisabetta, N. Rudini, Elisabetta Dejana (110746), Paolinelli, Roberta, Liebner, Stefan, Noemi Rudini, Monica Corada (217515), Cathrin J. Czupalla (441406), Kavi Devraj (441404), Artus, Cédric, Luigi Maddaluno, Cédric Artus (441405), Eleanna Papa, P. O. Couraud, Corada, Monica, Czupalla, Cathrin Jacqueline, Stefan Liebner, L. Maddaluno, Czupalla, Cathrin J., S. Liebner, Maddaluno, Luigi, Britta Engelhardt (307404), L. Ferrarini, Maddaluno Luigi, Devraj Kavi, Paolinelli Roberta, Liebner Stefan, Ferrarini Luca, Dejana Elisabetta, Papa Eleanna, Couraud Pierre Olivier, Rudini Noemi, Corada Monica, Artus Cédric, Czupalla Cathrin J., Engelhardt Britta   +65 more
core   +3 more sources

Magnetoelectric Nanoparticle‐Based Wireless Brain–Computer Interface: Underlying Physics and Projected Technology Pathway

Advanced Science, EarlyView.
Magnetoelectric nanoparticles (MENPs) enable fully wireless, minutely invasive neuromodulation, and potentially neural recording, by converting magnetic into electric and, conversely, electric into magnetic fields, respectively, at high spatiotemporal resolution.
Elric Zhang, Max Shotbolt, Mostafa Abdel‐Mottaleb, Shawnus Chen, Victoria Andre, Jieyuan Tian, Jonathan Shulgach, Max Murphy, Brian Noga, Ping Liang, Darcy Griffin, Douglas Weber, Marta Pardo, Salvador Pane, Sakhrat Khizroev   +14 more
wiley   +1 more source

The number of subgroups of the group $\Bbb{Z}_m\times \Bbb{Z}_n \times \Bbb{Z}_r \times \Bbb{Z}_s$

, 2016
13 pages ...
openaire   +2 more sources

OCA and towers in $\Cal P(\Bbb N)/fin$

, 1996
summary:We shall show that Open Coloring Axiom has different influence on the algebra $\Cal P(\Bbb N)/fin$ than on $\Bbb N^\Bbb N/fin$.
Farah, Ilijas
core  

Evaluation of various PAMPA models to identify the most discriminating method for the prediction of BBB permeability

, 2010
The Parallel Artificial Membrane Permeability Assay (PAMPA) has been successfully introduced into the pharmaceutical industry to allow useful predictions of passive oral absorption.
Brewster, Marcus E., Melis, Anouche, Mackie, Claire, Mensch, Jurgen, Verreck, Geert, Augustijns, Patrick, Claire Mackie, Marcus E. Brewster, Geert Verreck, Anouche Melis, Jurgen Mensch, Patrick Augustijns   +11 more
core   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells

mSphere, 2017
Bacterial meningitis is a serious infection of the central nervous system (CNS) that occurs after bacteria interact with and penetrate the blood-brain barrier (BBB). The BBB is comprised of highly specialized brain microvascular endothelial cells (BMECs)
Brandon J. Kim, Olivia B. Bee, Maura A. McDonagh, Matthew J. Stebbins, Sean P. Palecek, Kelly S. Doran, Eric V. Shusta   +6 more
doaj   +1 more source

On weighted spaces of functions harmonic in $\Bbb R^n$

, 2006
summary:The paper establishes integral representation formulas in arbitrarily wide Banach spaces $b^p_\omega(\Bbb R^n)$ of functions harmonic in the whole $\Bbb R^n$
Petrosyan, A. I.
core