Results 91 to 100 of about 159,800 (296)
Advanced Science, EarlyView.ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao +6 more
wiley +1 more source
BBB-conquering antibodies [PDF]
Science-Business eXchange, 2014 Roche has developed an improved transferrin receptor–targeting strategy that dramatically increases delivery of biologics to the brain. The team showed proof of concept in mice and now needs to adapt the system for primate brains.
openaire +1 more source
Forest plot of SMDs of rtPA’s effect on BBB.
, 2016 RtPA had significantly increased BBB permeability (95%CI of SMD, 0.62 to 1.23) and heterogeneity was extremely high (I2 = 85%). BBB, blood brain barrier; SMD, standardized mean difference; CI, confidence interval.
Yi-Fei Ren (3157734) +10 more
core +1 more source
A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy
Advanced Science, EarlyView.A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao +14 more
wiley +1 more source
Blood-Nanoparticle Interactions Create a Brain Delivery Superhighway for Doxorubicin
International Journal of NanomedicineZhuoxuan Li,1 Tatyana Kovshova,2 Julia Malinovskaya,2 Julian Knoll,1 Saeed Shanehsazzadeh,1 Nadezhda Osipova,2 Anastasia Chernysheva,3 Pavel Melnikov,2 Svetlana Gelperina,2 Matthias G Wacker1 1National University of Singapore, Department of Pharmacy and ...
Li Z +9 more
doaj
Key epigenetic and signaling factors in the formation and maintenance of the blood-brain barrier
eLifeThe blood-brain barrier (BBB) controls the movement of molecules into and out of the central nervous system (CNS). Since a functional BBB forms by mouse embryonic day E15.5, we reasoned that gene cohorts expressed in CNS endothelial cells (EC) at E13.5 ...
Jayanarayanan Sadanandan +17 more
doaj +1 more source
Advanced Science, EarlyView.In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang +11 more
wiley +1 more source
Homomorphic images of $\Bbb R$-factorizable groups
, 2006 summary:It is well known that every $\Bbb R$-factorizable group is $\omega $-narrow, but not vice versa. One of the main problems regarding $\Bbb R$-factorizable groups is whether this class of groups is closed under taking continuous homomorphic images ...
Tkachenko, M.
core +1 more source
Advanced Science, EarlyView.Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren +11 more
wiley +1 more source
The number of subgroups of the group $\Bbb{Z}_m\times \Bbb{Z}_n \times \Bbb{Z}_r \times \Bbb{Z}_s$
, 2016 13 pages ...
openaire +2 more sources