Results 121 to 130 of about 153,854 (301)

Hypoglycemic action of chicken meat extract in type-2 diabetic KKAy mice and GK rats

, 2009
10.1271/bbb.90328Bioscience, Biotechnology and Biochemistry73122583 ...
Sai-Zhen SIM, Meng-Kwoon SIM, Xiao-Guang XU, Daniel TSI, Wong, Y.-C., Sim, M.-K., Xu, X.-G., Tsi, D., Sim, S.-Z., Yong-Chiat WONG   +9 more
core   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Tame Galois realizations of $ GSp_4(\Bbb F_łl)$ over $\Bbb Q$ [PDF]

, 2011
peer ...
ARIAS DE REYNA DOMINGUEZ, Sara, Vila, Núria   +1 more
openaire  

Counting subgroups of the groups ${\Bbb Z}_{n_1} \times \cdots \times {\Bbb Z}_{n_k}$: a survey [PDF]

We present a survey of exact and asymptotic formulas on the number of cyclic subgroups and total number of subgroups of the groups ${\Bbb Z}_{n_1} \times \cdots \times {\Bbb Z}_{n_k}$, where $k\ge 2$ and $n_1,\ldots,n_k$ are arbitrary positive integers ...
Tóth, László
core   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Translational applicability of human blood-brain barrier spheroid models for the development of brain-penetrant therapeutic antibodies

Fluids and Barriers of the CNS
Drug delivery systems play a key role in the development of new therapeutic strategies for brain diseases. Antibodies capable of crossing the blood–brain barrier (BBB) have attracted considerable attention as promising drug carriers.
Seiya Ohki, Tomoki Fukatsu, Hideto Morimoto, Masafumi Kinoshita, Atsushi Imakiire, Ryuji Yamamoto, Hanae Morio, Hiroyuki Sonoda, Tomomi Furihata   +8 more
doaj   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

On weighted spaces of functions harmonic in $\Bbb R^n$

, 2006
summary:The paper establishes integral representation formulas in arbitrarily wide Banach spaces $b^p_\omega(\Bbb R^n)$ of functions harmonic in the whole $\Bbb R^n$
Petrosyan, A. I.
core   +1 more source