Results 31 to 40 of about 141,528 (311)
Inhibition of RIPK1 activity retarded BBB leakage.
, 2023 (A). The measurement of permeability of the BBB in wild-type and Ripk1D138N mutant mice. (B). The quantifications of fluorescence intensity of p-RIPK1 and leaked IgG during CIRI.
Yongjiao Wang (2192470) +4 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
BBB endothelial signature genes.
, 2013 BBB endothelial signature genes.
Roberta Paolinelli (237864) +12 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
International Journal of Electrochemical Science, 2013 The inhibition of single 1, 4-bis (benzimidazolyl) butane (BBB) and the mixture of BBB and 0.1 M NaCl on the corrosion of mild steel in 0.25 M H2SO4 solution was studied using weight loss and electrochemical methods.
Xiumei Wang +5 more
doaj +1 more source
Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier
Advanced Science, 2021 The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from entering the brain.
Jia Li +6 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang +8 more
wiley +1 more source
Fluids and Barriers of the CNS, 2021 Background Chronic cerebral hypoperfusion (CCH) is the leading cause of cerebral small vessel disease (CSVD). CCH is strongly associated with blood–brain barrier (BBB) dysfunction and white matter lesions (WMLs) in CSVD.
Zhengyu Sun +10 more
doaj +1 more source
Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu +11 more
wiley +1 more source
Molecular Brain, 2022 The integrity of the blood–brain barrier (BBB) is essential for normal central nervous system (CNS) functioning. Considering the significance of BBB in maintaining homeostasis and the neural environment, we aim to provide an overview of significant ...
Hema Kumari Alajangi +9 more
doaj +1 more source