Results 121 to 130 of about 43,134 (252)
Advanced Science, EarlyView.ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao +6 more
wiley +1 more source
The ${\Bbb Z}_2$ anomaly in some chiral gauge theories
, 2023 We revisit the simplest Bars-Yankielowicz (BY) model (the $\psi\eta$ model), starting from a model with an additional Dirac pair of fermions in the fundamental representation, together with a complex color-singlet scalar $\phi$ coupled to them through a ...
Luzio, Andrea +2 more
core +1 more source
Nature CommunicationsBlood-brain barrier (BBB) disintegration is a key contributor to neuroinflammation; however, the biological processes governing BBB permeability under physiological conditions remain unclear.
Sung-Hyun Yoon +14 more
doaj +1 more source
Advanced Science, EarlyView.Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh +7 more
wiley +1 more source
BBB dynamics: the lifespan perspective
Scientific ReportsRecent advances have shifted our understanding of the blood–brain barrier (BBB) not as a static wall, but as a dynamic and evolving system whose property is variable across the lifespan: acquisitive in early development, heterogeneous in adulthood, and ...
Xuefang Sophie Ren
doaj +1 more source
A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
Advanced Science, EarlyView.TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
wiley +1 more source
Surgery on $\widetilde{\Bbb{SL}}\times\Bbb{E}^n$-manifolds
, 2004 7 pages, AMS-LaTeX file, To appear in the Canadian Mathematical Bulletin.
Hillman, J. A., Roushon, S. K.
openaire +2 more sources
Advanced Science, EarlyView.Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li +17 more
wiley +1 more source
Investigating nanoparticle interactions with the human blood-brain barrier in vitro [PDF]
BIO Web of ConferencesSahin Hakan +7 more
doaj +1 more source
In vitro BBB model and assessment of protein fractionation.
, 2012 (A) A schematic drawing of the culture systems used in this study. (B) Gel image from silver-nitrate-stained 1D-PAGE of fractionated Triton X-100-extracted proteins of bovine brain capillary endothelial cells (BCECs) with either limited BBB functions ...
Christophe Flahaut (124880) +5 more
core +1 more source