Results 41 to 50 of about 43,134 (252)
F1000Research, 2017 Three male Caucasian patients with ALS were admitted to the hospital due to progressive dysphagia and dysarthria. During two 21-day courses of penicillin G and hydrocortisone, these patients’ dysphagia and dysarthria resolved.
Bert Tuk +2 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Open MedicineParaquat (PQ) is a frequently used herbicide with neurotoxic effects after acute or chronic exposure. Although in vitro evidence supports the PQ toxicity to dopamine cells, its in vivo effects (especially the chronic exposure) remain ambiguous.
Liu Tao +6 more
doaj +1 more source
review on the role of nanoparticles for targeted brain drug delivery
EXCLI Journal : Experimental and Clinical SciencesUnfortunately, nowadays, brain disorders, which include both neurological and mental disorders, are the main cause of years spent living with a disability worldwide. There are serious diseases with a high prevalence and a high mortality rate.
Payam Nawzad Mohammed +7 more
doaj +1 more source
Ensemble Predictions for TDC BBB-Martins Leaderboard
, 2023 Ensemble predictions for a drugs ability to penetrate the blood brain barrier using Therapeutic Data Commons BBB-Martins dataset. Includes .tsv files with the actual and predicted classifications of BBB permeability for each drug in the TDC test set ...
Rick Fontenot (14855842)
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Revisiting strategies to target ABC transporter-mediated drug resistance in CNS cancer
Cancer Biology & MedicineA significant number of anticancer drugs fail to treat primary and metastatic brain tumors primarily because of the complex blood-brain barrier (BBB) and overexpression of ATP-binding cassette (ABC) transporters, which decrease drug penetration into the ...
Haneen Amawi +9 more
doaj +1 more source
International Journal of Electrochemical Science, 2013 The inhibition of single 1, 4-bis (benzimidazolyl) butane (BBB) and the mixture of BBB and 0.1 M NaCl on the corrosion of mild steel in 0.25 M H2SO4 solution was studied using weight loss and electrochemical methods.
Xiumei Wang +5 more
doaj +1 more source
BBB endothelial signature genes.
, 2013 BBB endothelial signature genes.
Roberta Paolinelli (237864) +12 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source