Results 151 to 160 of about 154,979 (298)
Tame Galois realizations of $ GL_2(\Bbb F_l)$ over $\Bbb Q$
, 2009 This paper concerns the tame inverse Galois problem. For each prime number l, we construct infinitely many semistable elliptic curves over Q with good supersingular reduction at l. The Galois action on the l-torsion points of these elliptic curves provides tame Galois realizations of GL_2(F_l) over Q.
ARIAS DE REYNA DOMINGUEZ, Sara +1 more
openaire +1 more source
Advanced Science, EarlyView.Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang +4 more
wiley +1 more source
A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy
Advanced Science, EarlyView.A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao +14 more
wiley +1 more source
Advanced Science, EarlyView.In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang +11 more
wiley +1 more source
Advanced Science, EarlyView.Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren +11 more
wiley +1 more source
Precision Nanomedicine Volume 3 Issue 3 Table of Contents [PDF]
Precision Nanomedicinebbb
Lajos P Balogh
doaj
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
OCA and towers in $\Cal P(\Bbb N)/fin$
, 1996 summary:We shall show that Open Coloring Axiom has different influence on the algebra $\Cal P(\Bbb N)/fin$ than on $\Bbb N^\Bbb N/fin$.
Farah, Ilijas
core +1 more source
Astrocytic PDE7B Drives Blood-Brain Barrier Breakdown via Extracellular Vesicles in Demyelinating Disease. [PDF]
GliaDuan J +7 more
europepmc +1 more source