Results 101 to 110 of about 154,979 (298)

Microstructural and phase evolution of BaTiO3–BaO–B2O3–Bi2O3 glass composites during pressureless and spark plasma sintering

Materials & Design
BaTiO3–BaO–B2O3–Bi2O3 (BBB) glass composites were investigated to clarify how BBB content and sintering route control low-temperature densification, pore evolution, glass-derived phase redistribution, and crystalline phase development.
Alfian Noviyanto, Faried Latief, Bagas Haqi Arrosyid, Hiroyo Segawa, Toshiyuki Nishimura, Naoki Ohashi   +5 more
doaj   +1 more source

Magnetoelectric Nanoparticle‐Based Wireless Brain–Computer Interface: Underlying Physics and Projected Technology Pathway

Advanced Science, EarlyView.
Magnetoelectric nanoparticles (MENPs) enable fully wireless, minutely invasive neuromodulation, and potentially neural recording, by converting magnetic into electric and, conversely, electric into magnetic fields, respectively, at high spatiotemporal resolution.
Elric Zhang, Max Shotbolt, Mostafa Abdel‐Mottaleb, Shawnus Chen, Victoria Andre, Jieyuan Tian, Jonathan Shulgach, Max Murphy, Brian Noga, Ping Liang, Darcy Griffin, Douglas Weber, Marta Pardo, Salvador Pane, Sakhrat Khizroev   +14 more
wiley   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice

Nature Communications
Blood-brain barrier (BBB) disintegration is a key contributor to neuroinflammation; however, the biological processes governing BBB permeability under physiological conditions remain unclear.
Sung-Hyun Yoon, Chae youn Kim, Eunju Lee, Changjun Lee, Kyung-Seo Lee, Jaeho Lee, Hana Park, Bokeum Choi, Inhwa Hwang, Junhan Kim, Tae-Gyun Kim, Junghyun Son, Young-Min Hyun, Seunghee Hong, Je-Wook Yu   +14 more
doaj   +1 more source

$\Omega_{bbb}\Omega_{bbb}\Omega_{bbb}$ tribaryons

We study the possible existence of bound states of three $\Omega_{bbb}$ baryons. We consider only $S$ wave interactions and we start from recent lattice QCD results which give a strongly attractive potential between two $\Omega_{bbb}$ baryons in the $^1S_0$ channel. We analyze different scenarios.
Garcilazo, H., Valcarce, A.
openaire   +1 more source

TITAN-BBB: Predicting BBB Permeability using Multi-Modal Deep-Learning Models

Computational prediction of blood-brain barrier (BBB) permeability has emerged as a vital alternative to traditional experimental assays, which are often resource-intensive and lowthroughput to meet the demands of early-stage drug discovery.
Saeed, Fahad, de Oliveira, Gabriel Bianchin   +1 more
core   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

BBB dynamics: the lifespan perspective

Scientific Reports
Recent advances have shifted our understanding of the blood–brain barrier (BBB) not as a static wall, but as a dynamic and evolving system whose property is variable across the lifespan: acquisitive in early development, heterogeneous in adulthood, and ...
Xuefang Sophie Ren
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

PAMPA-BBB assay results.

, 2013
A linear correlation between experimental and reported permeability of selected commercial drugs using the experimental conditions described in the PAMPA-BBB assay methodology was found (10a). The permeability (Pe 10−6 cm s−1) value obtained in the PAMPA-
Valle Palomo (356637), Emanuela Esposito (286778), Carmen Gil (146118), Irene Paterniti (310894), Salvatore Cuzzocrea (37948), Myriam Redondo (356639), Daniel I. Perez (356641), Emanuela Mazzon (37947), Ana Martinez (1313100), Daniela Impellizzeri (310892)   +9 more
core   +1 more source