Results 181 to 190 of about 116,733 (246)

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Mechanistic Landscape and Farm to Fork Control Strategies for <i>Streptococcus suis</i>: An Emerging Foodborne Threat. [PDF]

Transbound Emerg Dis
Yao W, Chen M, Ren H, Luo Q, Wang X, Akhtar M, Bhutta ZA, Peng L, Nawaz MY, Hasan MM, Kulyar MF, Fang R.   +11 more
europepmc   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairment. [PDF]

Proc Natl Acad Sci U S A
Dhar M, Vázquez-Rosa E, Chaubey K, Miller E, Corella SG, Chakraborty S, Tripathi SJ, Das T, Liao X, Alosman MA, Fang H, Koh Y, Sridharan PS, Franke K, Cintrón-Pérez CJ, Cintrón-Pérez AA, Tomco T, Indrakumar V, Rubin PJ, Pieper JG, Ashiku LA, Shin MK, Tang X, Padmanabhan R, Haragopal H, Flanagan ME, Jain R, Winters BD, Wilson BM, Paul BD, Jain MK, Pieper AA.   +31 more
europepmc   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Role of the WNT signalling pathway in physiological and pathological blood-brain barrier. [PDF]

Ann Med
Yang F, Wang F, Jiang Y, Qian D, Chen L.
europepmc   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Tannic Acid Mitigates Monosodium Glutamate‐Induced Cortical Damage by Modulating Synaptic and Calcium‐Related Gene and Protein Expression

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neurotoxicity induced by excessive glutamatergic signaling is associated with synaptic dysfunction, calcium imbalance, and oxidative stress, which are key molecular events implicated in several neurodegenerative conditions. Monosodium glutamate (MSG), a common flavor enhancer, may exert neurotoxic effects, particularly on synaptic integrity ...
Medine Sibel Karagac, Enver Fehim Koçpinar, Hamid Ceylan   +2 more
wiley   +1 more source

Overcoming the blood-brain barrier in Alzheimer's disease: translational perspectives on advanced drug delivery platforms. [PDF]

Front Neurosci
Roamcharern N, Yubolphan R.
europepmc   +1 more source