Results 11 to 20 of about 141,528 (311)
The Blood–Brain Barrier (BBB) Score
, 2019 The blood–brain barrier (BBB) protects the brain from the toxic side effects of drugs and exogenous molecules. However, it is crucial that medications developed for neurological disorders cross into the brain in therapeutic concentrations.
Hyeok Jun Lee (7543277) +3 more
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Random Forest TDC-BBB predictions
, 2023 Random Forest predictions for a drugs ability to penetrate the blood brain barrier using Therapeutic Data Commons BBB-Martins dataset. Includes .tsv files with the actual and predicted classifications of BBB permeability for each drug in the TDC test ...
Rick Fontenot (14855842)
core +1 more source
Global Perspective of Novel Therapeutic Strategies for the Management of NeuroAIDS
Biomolecular Concepts, 2018 Among Human immunodeficiency virus (HIV) infected individuals, around two-thirds of patients present with neuroAIDS, where HIV-associated neurocognitive disorders (HAND), and HIV-associated dementia (HAD) are the most prevailing neurological ...
Kumar Swatantra +4 more
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Engineered models for studying blood-brain-barrier-associated brain physiology and pathology [PDF]
Organoid, 2021 The blood-brain barrier (BBB) is a transport barrier that suppresses the translocation of potentially harmful substances to the brain tissue. Although the BBB is known to be associated with many kinds of neuropathology, such as neuroinflammation and ...
Hong Nam Kim
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In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties. [PDF]
PLoS ONE, 2013 The blood-brain barrier (BBB) restricts the entry of circulating drugs and xenobiotics into the brain, and thus its permeability to substances is a critical factor that determines their central effects.
Fuyuko Takata +10 more
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Deciphering the role of MYC Gene Variants in Childhood Cerebral Adrenoleukodystrophy (ccALD) using Integrative Transcriptomic and Variant Analysis [PDF]
BIO Web of ConferencesObjective: Childhood cerebral adrenoleukodystrophy (ccALD) is a severe neurodegenerative disorder characterized by rapid demyelination and disruption of the blood-brain barrier (BBB).
Jain Chakresh Kumar +3 more
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Annihilating submodule graph for modules [PDF]
Transactions on Combinatorics, 2018 Let $R$ be a commutative ring and $M$ an $R$-module. In this article, we introduce a new generalization of the annihilating-ideal graph of commutative rings to modules. The annihilating submodule graph of $M$, denoted by $Bbb G(M)$, is an
Saeed Safaeeyan
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Formation and maintenance of the BBB
Mechanisms of Development, 2015 The central nervous system (CNS) is vascularized by a dense capillary network that is critical to deliver oxygen and nutrients, and remove carbon dioxide and waste products, from the neural tissue. These blood vessels contain a series of properties, termed the blood-brain barrier (BBB), which distinguishes them from vasculature in other tissues ...
Blanchette, Marie, Daneman, Richard
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Drug Delivery, 2020 Reconstituted high density lipoprotein (rHDL) has been regarded as a promising brain-targeting vehicle for anti-glioma drugs under the mediation of apolipoprotein A-I (apoA-I).
Jin Li +6 more
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Effects of Natural Polyphenols on Oxidative Stress-Mediated Blood-Brain Barrier Dysfunction
Antioxidants, 2022 The blood-brain barrier (BBB), which consists mainly of brain microvascular endothelial cells and astrocytes connected by tight junctions (TJs) and adhesion molecules (AMs), maintains the homeostatic balance between brain parenchyma and extracellular ...
Yeonjae Kim +5 more
doaj +1 more source