Results 61 to 70 of about 153,854 (301)

What “Hides” Behind Sovereign Debt Ratings? [PDF]

In this paper we study the determinants of sovereign debt credit ratings using rating notations from the three main international rating agencies, for the period 1995-2005. We employ panel estimation and random effects ordered probit approaches to assess
António Afonso, Pedro Gomes, Philipp Rother   +2 more
core   +2 more sources

Mechanisms of Astrocyte Action in the Blood Brain Barrier: From Structural Support to Dynamic Regulation

Journal of Integrative Neuroscience
The blood-brain barrier (BBB) consists of endothelial cells enmeshed by brain microvessels, surrounding basement membrane, pericytes and astrocyte pedicles.
Di Feng, Lili Wang, Aoyu Hu, Shanshan Zhang   +3 more
doaj   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Ensemble Predictions for TDC BBB-Martins Leaderboard

, 2023
Ensemble predictions for a drugs ability to penetrate the blood brain barrier using Therapeutic Data Commons BBB-Martins dataset. Includes .tsv files with the actual and predicted classifications of BBB permeability for each drug in the TDC test set ...
Rick Fontenot (14855842)
core   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Inhibition of RIPK1 activity retarded BBB leakage.

, 2023
(A). The measurement of permeability of the BBB in wild-type and Ripk1D138N mutant mice. (B). The quantifications of fluorescence intensity of p-RIPK1 and leaked IgG during CIRI.
Yongjiao Wang (2192470), Xiaohui Wu (228851), Min Gong (451173), Ying Li (38224), Chaonan Yang (16827898)   +4 more
core   +1 more source

Blood–Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control

Advanced Healthcare Materials, EarlyView.
Conventional therapies suffer from poor blood–brain barrier (BBB) penetration and disordered ion/reactive oxygen species (ROS) homeostasis, hindering precise neurological treatment. Electrochemical strategies achieve accurate spatiotemporal regulation of neural homeostasis.
Xiaokang Hu, Caiyu Liu, Meijun Pang, Zhiyuan Shi, Dong Ming, Xiuyun Liu   +5 more
wiley   +1 more source

Subgroups and products of $\Bbb R$-factorizable $P$-groups

, 2004
summary:We show that {\it every\/} subgroup of an $\Bbb R$-factorizable abelian $P$-group is topologically isomorphic to a {\it closed\/} subgroup of another $\Bbb R$-factorizable abelian $P$-group.
Tkachenko, Michael, Hernández, Constancio   +1 more
core   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Discrete parabolic groups in ${\rm PSL}(3, \Bbb{C})$ [PDF]

, 2022
We study and classify the purely parabolic discrete subgroups of $PSL(3,\Bbb{C})$. This includes all discrete subgroups of the Heisenberg group ${\rm Heis}(3,\Bbb{C})$.
Cano, Angel, Barrera, Waldemar, Navarrete, Juan Pablo, Seade, Jose   +3 more
core   +1 more source