Results 101 to 110 of about 153,854 (301)

The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent

Frontiers in Neurology, 2019
The maintenance of blood-brain barrier (BBB) integrity is essential for providing a suitable environment for nervous tissue function. BBB disruption is involved in many central nervous system diseases, including epilepsy.
Natália Ferreira Mendes, Aline Priscila Pansani, Elis Regina Ferreira Carmanhães, Poliana Tange, Juliana Vieira Meireles, Mayara Ochikubo, Jair Ribeiro Chagas, Alexandre Valotta da Silva, Glaucia Monteiro de Castro, Luciana Le Sueur-Maluf   +9 more
doaj   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice

Nature Communications
Blood-brain barrier (BBB) disintegration is a key contributor to neuroinflammation; however, the biological processes governing BBB permeability under physiological conditions remain unclear.
Sung-Hyun Yoon, Chae youn Kim, Eunju Lee, Changjun Lee, Kyung-Seo Lee, Jaeho Lee, Hana Park, Bokeum Choi, Inhwa Hwang, Junhan Kim, Tae-Gyun Kim, Junghyun Son, Young-Min Hyun, Seunghee Hong, Je-Wook Yu   +14 more
doaj   +1 more source

$\Omega_{bbb}\Omega_{bbb}\Omega_{bbb}$ tribaryons

We study the possible existence of bound states of three $\Omega_{bbb}$ baryons. We consider only $S$ wave interactions and we start from recent lattice QCD results which give a strongly attractive potential between two $\Omega_{bbb}$ baryons in the $^1S_0$ channel. We analyze different scenarios.
Garcilazo, H., Valcarce, A.
openaire   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

BBB dynamics: the lifespan perspective

Scientific Reports
Recent advances have shifted our understanding of the blood–brain barrier (BBB) not as a static wall, but as a dynamic and evolving system whose property is variable across the lifespan: acquisitive in early development, heterogeneous in adulthood, and ...
Xuefang Sophie Ren
doaj   +1 more source

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source

PAMPA-BBB assay results.

, 2013
A linear correlation between experimental and reported permeability of selected commercial drugs using the experimental conditions described in the PAMPA-BBB assay methodology was found (10a). The permeability (Pe 10−6 cm s−1) value obtained in the PAMPA-
Valle Palomo (356637), Emanuela Esposito (286778), Carmen Gil (146118), Irene Paterniti (310894), Salvatore Cuzzocrea (37948), Myriam Redondo (356639), Daniel I. Perez (356641), Emanuela Mazzon (37947), Ana Martinez (1313100), Daniela Impellizzeri (310892)   +9 more
core   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source