Results 91 to 100 of about 153,854 (301)

Blood-Nanoparticle Interactions Create a Brain Delivery Superhighway for Doxorubicin

International Journal of Nanomedicine
Zhuoxuan Li,1 Tatyana Kovshova,2 Julia Malinovskaya,2 Julian Knoll,1 Saeed Shanehsazzadeh,1 Nadezhda Osipova,2 Anastasia Chernysheva,3 Pavel Melnikov,2 Svetlana Gelperina,2 Matthias G Wacker1 1National University of Singapore, Department of Pharmacy and ...
Li Z, Kovshova T, Malinovskaya J, Knoll J, Shanehsazzadeh S, Osipova N, Chernysheva A, Melnikov P, Gelperina S, Wacker MG   +9 more
doaj  

BBB-conquering antibodies [PDF]

Science-Business eXchange, 2014
Roche has developed an improved transferrin receptor–targeting strategy that dramatically increases delivery of biologics to the brain. The team showed proof of concept in mice and now needs to adapt the system for primate brains.
openaire   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

The number of subgroups of the group $\Bbb{Z}_m\times \Bbb{Z}_n \times \Bbb{Z}_r \times \Bbb{Z}_s$

, 2016
13 pages ...
openaire   +2 more sources

Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro [PDF]

, 2013
Reproducing the characteristics and the functional responses of the blood–brain barrier (BBB) in vitro represents an important task for the research community, and would be a critical biotechnological breakthrough.
Eleanna Papa (441409), Rudini, Noemi, B. Engelhardt, Papa, Eleanna, E. Papa, M. Corada, Kavi Devraj, Pierre Olivier Couraud (383879), Couraud, Pierre Olivier, Luca Ferrarini, Monica Corada, Roberta Paolinelli, Pierre Olivier Couraud, K. Devraj, Luigi Maddaluno (441408), Cathrin J Czupalla, Engelhardt, Britta, Britta Engelhardt, Stefan Liebner (307398), R. Paolinelli, Noemi Rudini (441407), C. J. Czupalla, Cédric Artus, Luca Ferrarini (441403), E. Dejana, Elisabetta Dejana, C. Artus, Roberta Paolinelli (237864), Ferrarini, Luca, Devraj, Kavi, Dejana, Elisabetta, N. Rudini, Elisabetta Dejana (110746), Paolinelli, Roberta, Liebner, Stefan, Noemi Rudini, Monica Corada (217515), Cathrin J. Czupalla (441406), Kavi Devraj (441404), Artus, Cédric, Luigi Maddaluno, Cédric Artus (441405), Eleanna Papa, P. O. Couraud, Corada, Monica, Czupalla, Cathrin Jacqueline, Stefan Liebner, L. Maddaluno, Czupalla, Cathrin J., S. Liebner, Maddaluno, Luigi, Britta Engelhardt (307404), L. Ferrarini   +52 more
core   +3 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells

mSphere, 2017
Bacterial meningitis is a serious infection of the central nervous system (CNS) that occurs after bacteria interact with and penetrate the blood-brain barrier (BBB). The BBB is comprised of highly specialized brain microvascular endothelial cells (BMECs)
Brandon J. Kim, Olivia B. Bee, Maura A. McDonagh, Matthew J. Stebbins, Sean P. Palecek, Kelly S. Doran, Eric V. Shusta   +6 more
doaj   +1 more source

Minimal surfaces in ${\Bbb M}\sp 2\times\Bbb R$

Illinois Journal of Mathematics, 2002
We study the geometry and topology of properly embedded minimal surfaces in $M\times\mathbb{R}$, where $M$ is a Riemannian surface. When $M$ is a round sphere, we give examples of all genus and we prove such minimal surfaces have exactly two ends or equal $M\times\{t\}$, for some real $t$.
openaire   +2 more sources

Magnetoelectric Nanoparticle‐Based Wireless Brain–Computer Interface: Underlying Physics and Projected Technology Pathway

Advanced Science, EarlyView.
Magnetoelectric nanoparticles (MENPs) enable fully wireless, minutely invasive neuromodulation, and potentially neural recording, by converting magnetic into electric and, conversely, electric into magnetic fields, respectively, at high spatiotemporal resolution.
Elric Zhang, Max Shotbolt, Mostafa Abdel‐Mottaleb, Shawnus Chen, Victoria Andre, Jieyuan Tian, Jonathan Shulgach, Max Murphy, Brian Noga, Ping Liang, Darcy Griffin, Douglas Weber, Marta Pardo, Salvador Pane, Sakhrat Khizroev   +14 more
wiley   +1 more source

Microstructural and phase evolution of BaTiO3–BaO–B2O3–Bi2O3 glass composites during pressureless and spark plasma sintering

Materials & Design
BaTiO3–BaO–B2O3–Bi2O3 (BBB) glass composites were investigated to clarify how BBB content and sintering route control low-temperature densification, pore evolution, glass-derived phase redistribution, and crystalline phase development.
Alfian Noviyanto, Faried Latief, Bagas Haqi Arrosyid, Hiroyo Segawa, Toshiyuki Nishimura, Naoki Ohashi   +5 more
doaj   +1 more source