Results 1 to 10 of about 25,164 (136)

Long-term effects of BCG vaccination on telomere length and telomerase activity [PDF]

iScience
Summary: This study explores the effects of Bacillus Calmette-Guérin (BCG) vaccination on telomere maintenance, an aging-related process, in immune cells.
Ozlem Bulut, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Charlotte J. de Bree, Vera P. Mourits, Gizem Kilic, Priya A. Debisarun, Marijke P.A. Baltissen, Joost H.A. Martens, Jorge Domínguez-Andrés, Leo A.B. Joosten, Mihai G. Netea   +11 more
doaj   +2 more sources

BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination [PDF]

Nature Communications
Bacillus Calmette-Guèrin - vaccination induces not only protection in infants and young children against severe forms of tuberculosis, but also against non-tuberculosis related all-cause mortality. To delineate different factors influencing mycobacterial
Krista E. van Meijgaarden, Wenchao Li, Simone J. C. F. M. Moorlag, Valerie A. C. M. Koeken, Hans J. P. M. Koenen, Leo A. B. Joosten, Annapurna Vyakarnam, Asma Ahmed, Srabanti Rakshit, Vasista Adiga, Tom H. M. Ottenhoff, Yang Li, Mihai G. Netea, Simone A. Joosten   +13 more
doaj   +2 more sources

The influence of neonatal BCG vaccination on in vitro cytokine responses to Plasmodium falciparum [PDF]

BMC Immunology
Background Bacillus Calmette–Guérin (BCG) vaccination has off-target protective effects against infections unrelated to tuberculosis. Among these, murine and human studies suggest that BCG vaccination may protect against malaria.
NL Messina, M Wang, EK Forbes, B Freyne, WP Hasang, S Germano, R Bonnici, F Summons, K Gardiner, S Donath, R Gordon, SJ Rogerson, N Curtis   +12 more
doaj   +2 more sources

BCG vaccination is associated with longitudinal changes in systemic eicosanoid levels in elderly individuals: A secondary outcome analysis [PDF]

Heliyon
We investigated how BCG vaccination affects the levels of certain eicosanoids, namely Leukotriene B4, 15-epimer of LXA4, prostaglandin F2, Lipoxin A4, Prostaglandin E2 and Resolvin D1 in the plasma of healthy elderly individuals (aged 60–80) before ...
Pavan Kumar Nathella, Chandrasekaran Padmapriyadarsini, Arul Nancy, Kushiyasri Karunanithi, Nandhini Selvaraj, Rachel Mariam Renji, B.M. Shrinivasa, Subash Babu   +7 more
doaj   +2 more sources

BCG Vaccination Suppresses Glucose Intolerance Progression in High-Fat-Diet-Fed C57BL/6 Mice [PDF]

Medicina
Background and Objectives: Mycobacterium bovis Bacillus Calmette–Guérin (BCG) vaccine administration has been suggested to prevent glucose metabolism abnormalities and fatty liver in genetically obese ob/ob mice; however, it is not clear whether the ...
Haruna Arakawa, Masashi Inafuku
doaj   +2 more sources

Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination

Heliyon, 2023
The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. Within an international randomised trial (‘
Paola Villanueva, Nigel W. Crawford, Mariana Garcia Croda, Simone Collopy, Bruno Araújo Jardim, Tyane de Almeida Pinto Jardim, Laurens Manning, Michaela Lucas, Helen Marshall, Cristina Prat-Aymerich, Alice Sawka, Ketaki Sharma, Darren Troeman, Ushma Wadia, Adilia Warris, Nicholas Wood, Nicole L. Messina, Nigel Curtis, Laure F. Pittet   +18 more
doaj   +1 more source

BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals

International Journal of Infectious Diseases, 2021
Objective: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell
Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Anuradha Rajamanickam, Perumal Kannabiran Bhavani, Arul Nancy, Bharathi Jeyadeepa, Nandhini Selvaraj, Dinesh Ashokan, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Srikanth Tripathy, Subash Babu   +11 more
doaj   +1 more source

BCG vaccination impact on mortality and recovery rates in COVID-19: A meta-analysis

Monaldi Archives for Chest Disease, 2021
COVID-19 is a pandemic caused by SARS-CoV-2 virus which is a very worrisome public health emergency. In this study, we compared the mortality rate and recovery rate in countries with and without BCG vaccination policy.
Surjit Singh, Daisy Khera, Ankita Chugh, Sameer Khasbage, Pushpinder S. Khera, Vinay Kumar Chugh   +5 more
doaj   +1 more source

BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.

PLoS ONE, 2021
BCG vaccination is known to induce innate immune memory, which confers protection against heterologous infections. However, the effect of BCG vaccination on the conventional adaptive immune cells subsets is not well characterized.
Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Anuradha Rajamanickam, Perumal Kannabiran Bhavani, Arul Nancy, Bharathi Jayadeepa, Nandhini Selvaraj, Dinesh Asokan, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Srikanth Tripathy, Subash Babu   +11 more
doaj   +2 more sources

Mapping BCG vaccination coverage in Ethiopia between 2000 and 2019

BMC Infectious Diseases, 2022
Introduction The Bacille-Calmette–Guerin (BCG) vaccination remains the primary strategy to prevent severe disseminated TB in young children, particularly in high TB-burden countries such as Ethiopia.
Kendalem Asmare Atalell, Mulat Asrade Alemayehu, Nahom Worku Teshager, Getaneh Mulualem Belay, Tewodros Getaneh Alemu, Degefaye Zelalem Anlay, Amare Wondim, Kefyalew Addis Alene   +7 more
doaj   +1 more source