Genomic characteristics of two most widely used BCG vaccine strains: Danish 1331 and Pasteur 1173P2. [PDF]
BMC Genomics, 2022 Background Bacillus Calmette–Guérin (BCG) refers to a group of vaccine strains with unique genetic characteristics. BCG is the only available vaccine for preventing tuberculosis (TB).
Asadian M +3 more
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Culture filtrate proteins from BCG act as adjuvants for cytotoxic T lymphocyte induction
Frontiers in Immunology, 2023 Mycobacterium bovis bacilli Calmette-Guerin (BCG) is a licensed vaccine against tuberculosis. It requires attenuated live bacteria to be effective, possibly because actively secreted proteins play a critical role in inducing anti-tuberculosis immunity ...
Satoru Mizuno +7 more
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The influence of BCG on vaccine responses – a systematic review
Expert Review of Vaccines, 2018 Introduction: Bacillus Calmette-Guérin (BCG) vaccine is one of the most widely used vaccines worldwide. In addition to providing protection against tuberculosis, it has non-specific (heterologous) immunomodulatory effects.
Petra Zimmermann, Nigel Curtis
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TUBERCULIN RESPONSE AND SCAR FORMATION IN BCG VACCINATED 7-YEARS OLD SCHOOLCHILDREN IN SOFIA, BULGARIA [PDF]
Journal of IMAB, 2015 This study has been designed to evaluate safety and efficacy of BCG vaccine in school-entering children in terms of tuberculin response to PPD and scar formation as indicators for successful vaccination.
Tzvetelina Stefanova
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Future Path Toward TB Vaccine Development: Boosting BCG or Re-educating by a New Subunit Vaccine [PDF]
Frontiers in Immunology, 2018 Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb), kills 5,000 people per day globally. Rapid development and spread of various multi drug-resistant strains of Mtb emphasize that an effective vaccine is still the most ...
Nancy Gupta +5 more
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Differential Adverse Event Profiles Associated with BCG as a Preventive Tuberculosis Vaccine or Therapeutic Bladder Cancer Vaccine Identified by Comparative Ontology-Based VAERS and Literature Meta-Analysis. [PDF]
PLoS ONE, 2016 M. bovis strain Bacillus Calmette-Guérin (BCG) has been the only licensed live attenuated vaccine against tuberculosis (TB) for nearly one century and has also been approved as a therapeutic vaccine for bladder cancer treatment since 1990.
Jiangan Xie +3 more
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Bacillus Calmette-Guérin vaccine-related complications in children in Oman
Annals of Saudi Medicine, 2021 BACKGROUND: Bacillus Calmette-Guérin (BCG) vaccine-related complications are frequently observed in children in Oman. There are a few regional studies on BCG complications, but none from Oman.
Badria Al Waili +4 more
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Frontiers in Immunology, 2022 Tuberculosis (TB) is a major global health problem and the only currently-licensed vaccine, BCG, is inadequate. Many TB vaccine candidates are designed to be given as a boost to BCG; an understanding of the BCG-induced immune response is therefore ...
Julia Bitencourt +19 more
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Non-Tuberculous Mycobacteria Interference with BCG-Current Controversies and Future Directions
Vaccines, 2020 The global tuberculosis (TB) epidemic caused by the bacterial pathogen Mycobacterium tuberculosis (M.tb) continues unabated. The Mycobacterium bovis bacillus Calmette–Guérin (BCG) vaccination is widely utilized worldwide to protect against infection with
Deepshikha Verma +2 more
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BCG: a vaccine with multiple faces
Human Vaccines & Immunotherapeutics, 2020 BCG has been recommended because of its efficacy against disseminated and meningeal tuberculosis. The BCG vaccine has other mechanisms of action besides tuberculosis protection, with immunomodulatory properties that are now being discovered. Reports have
Marco Antonio Yamazaki-Nakashimada +4 more
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