Results 41 to 50 of about 58,969 (272)

Research progress in the off-target effects of Bacille Calmette–Guérin vaccine

Chinese Medical Journal
. Bacille Calmette–Guérin (BCG) vaccine is designed to provide protection against tuberculosis (TB). However, numerous epidemiological, clinical, and immunological studies have shown that BCG vaccination affects neonatal and infant mortality, which may ...
Yanfei Wu, Xiaoyin Zhang, Li Zhou, Jiayu Lu, Fengcai Zhu, Jingxin Li, Jing Ni, Xuehong Zhang   +7 more
doaj   +1 more source

Bacterial outer membrane vesicles and vaccine applications [PDF]

, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo, Acosta, Armando, Campa, Concepcion, Cardoso, Daniel, Fernandez, Sonsire, Ferro, Valerie, Garcia, Luis, Perez, Jose Luis, Rosenqvist, Einar, Sarmiento, Maria Elena, Zayas, Caridad   +10 more
core   +2 more sources

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Causes of variation in BCG vaccine efficacy: examining evidence from the BCG REVAC cluster randomized trial to explore the masking and the blocking hypotheses.

, 2014
BCG protection varies and in some places (nearest the equator) is low or absent. Understanding this variation can inform the efforts to develop new vaccines against tuberculosis.
Abu-Raddad, Agger, Alvaro A. Cruz, Andersen, Barbosa, Barreto, Barreto, Barreto, Bernd Genser, Bierrenbach, Black, Brandt, Buddle, Camargos, Clemax Sant’Anna, Colditz, Colditz, Comstock, Cunha, Daniel Pilger, de Lisle, Demangel, Dourado, Dye, Dye, Fine, Fine, Fine, Global Programme on Tuberculosis, Harboe, Health Protection Agency Centre for Infections, Hernandez-Pando, Hoefsloot, Kamala, Kaufmann, Kaufmann, Laura C. Rodrigues, Liang, Lozes, Maria Y. Ichihara, Mauricio L. Barreto, Miguel A. Hijjar, Ministerio da Saude, Nascimento-Costa, Palmer, Pereira, Pereira, Pereira, Rodrigues, Rodrigues, Russell, Sergio S. Cunha, Smith, Susan M. Pereira, Tameris, Tuberculosis Prevention Trial, Wunsch Filho   +56 more
core   +1 more source

Chitosan-alginate microparticulate delivery system for an alternative route of administration of BCG vaccine [PDF]

, 2013
Immunisation against M. tuberculosis with current available BCG vaccine lacks efficacy in preventing adult pulmonary tuberculosis. Targeting nasal mucosa is an attractive option for a more effective immunization.
Almeida, António J., Amaral, Rita, Caetano, Liliana Aranha, Figueiredo, Lara, Gonçalves, Lídia M.   +4 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Bacille Calmette-Guérin Vaccine Strain Modulates the Ontogeny of Both Mycobacterial-Specific and Heterologous T Cell Immunity to Vaccination in Infants

Frontiers in Immunology, 2019
Differences in Bacille Calmette-Guérin (BCG) immunogenicity and efficacy have been reported, but various strains of BCG are administered worldwide. Since BCG immunization may also provide protection against off-target antigens, we sought to identify the ...
Agano Kiravu, Sophia Osawe, Anna-Ursula Happel, Trishana Nundalall, Jerome Wendoh, Sophie Beer, Nobomi Dontsa, Olatogni Berenice Alinde, Sikiratu Mohammed, Pam Datong, D. William Cameron, Kenneth Rosenthal, Alash'le Abimiku, Alash'le Abimiku, Heather B. Jaspan, Heather B. Jaspan, Clive M. Gray, Clive M. Gray   +17 more
doaj   +1 more source

Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model. [PDF]

, 2014
BACKGROUND: Bacillus Calmette-Guerin (BCG) vaccine is the most widely administered vaccine in the world, yet its mechanism of action remains unclear. We hypothesize that certain immune pathways are associated with reduced mycobacterial growth following ...
Chomka, Agnieszka, Fletcher, Helen A, Harris, Stephanie A, Matsumiya, Magali, McShane, Helen, Meyer, Joel, Satti, Iman, Stockdale, Lisa   +7 more
core   +1 more source

Establishment of a biosafe murine model of skeletal tuberculosis using Mycobacterium smegmatis

Animal Models and Experimental Medicine, EarlyView.
This study developed a biosafe, accessible, and versatile murine model of bone TB using Mycobacterium smegmatis, a fast‐growing, nonpathogenic mycobacterial species with high genomic homology to Mycobacterium tuberculosis. Three infection routes—subperiosteal calvarial injection, intratibial injection, and intracardiac (left ventricular) inoculation ...
Yewei Jia, Yuhuai Guo, Yusheng Yang, Jie Zhang, Ziyang Zhang, Ying Qu, Jiulin Tan, Jie Shen, Nathachit Limjunyawong, Jianzhong Xu, Zehua Zhang, Fei Luo, Ce Dou   +12 more
wiley   +1 more source

Adverse reactions due to the bacillus Calmette-Guerin vaccine: Twenty Tunisian cases

Indian Journal of Dermatology, 2018
Background: Bacillus Calmette-Guérin (BCG) vaccine is a widely used vaccine. Management of local BCG complications differs between clinicians, and the optimal approach remains unclear.
Khadija Sellami, Meriem Amouri, Sana Kmiha, Emna Bahloul, Hajer Aloulou, Lamia Sfaihi, R Guirat, Madiha Mseddi, T Kamoun, Mongia Hachicha, Hamida Turki   +10 more
doaj   +1 more source