Results 61 to 70 of about 723,552 (238)

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Use of BCG vaccine for enhancement the immune response of sheep to Rev.1 Vaccination [PDF]

Journal of Veterinary Medical Research, 2008
This study was conducted to evaluate the protective effect of Brucella melitensis Rev.1 and the use of BCG vaccine as immunostimulant by subcutaneous injection in Guinea pigs. Lab.
S. M. S. El-Ayouby, O. R. Salib, H. K. El-Deen   +2 more
doaj   +1 more source

Immune System Development—Pro Tips for Paediatricians

Acta Paediatrica, EarlyView.
ABSTRACT There are many misconceptions about the immune system in children, its impact on infectious disease susceptibility and its role in the rapidly increasing rates of immune mediated diseases in industrialized societies. In this mini review, I will discuss common believes and the data supporting or countering such believes, with a focus on ...
Petter Brodin
wiley   +1 more source

The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine

npj Vaccines, 2021
Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on mycobacterial diseases, an increasing amount of epidemiological and experimental ...
Junli Li, Lingjun Zhan, Chuan Qin
doaj   +1 more source

A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA

Acta Paediatrica, EarlyView.
ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Tobias Alfvén, Tania Reza, Alieu Sowe
wiley   +1 more source

Immunogenicity of mannan derived from Mycobacterium bovis as a promising adjuvant in vaccine BCG

Iranian Journal of Microbiology
Background and Objectives: Lipoarabinomannan is one of the components of the significant structural cell surfaces of mycobacteria and serves as an immunostimulatory factor.
Rajab Mardani, Ariana Alavi, Seyed Dawood Mousavi Nasab, Nayebali Ahmadi, Mohammad Javad Hossein Tehrani, Maryam Shahali, Delaram Doroud   +6 more
doaj   +1 more source

INtraVESical immunoTherapy (INVEST) prior to radical cystectomy for bladder cancer: trial protocol

BJU International, EarlyView.
Background High‐risk non‐muscle‐invasive bladder cancer (HRNMIBC) has a variable prognosis, managed predominantly by local surgical resection and intravesical Bacillus Calmette–Guérin (BCG), or radical cystectomy (RC). Current treatments are poorly tolerated, have supply limitations and often fail to control the disease.
Ruby Lister‐Whelan, Ethan Senior, Jessica Kendall, Jamie B. Oughton, Fiona Collinson, Jon Griffin, Rachel Hubbard, Steven Kennish, Aidan Noon, Derek J. Rosario, Irbaz B. Riaz, Julie Telliez, James W. F. Catto, Syed A. Hussain   +13 more
wiley   +1 more source

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses

Journal of Allergy and Clinical Immunology, 2017
Background Newborns display distinct immune responses, leaving them vulnerable to infections and impairing immunization. Targeting newborn dendritic cells (DCs), which integrate vaccine signals into adaptive immune responses, might enable development of ...
David J. Dowling, E. Scott, A. Scheid, Ilana Bergelson, S. Joshi, Carlo Pietrasanta, Spencer E. Brightman, Guzmán Sanchez-Schmitz, S. V. van Haren, Jana Ninković, D. Kats, C. Guiducci, A. de Titta, Daniel K. Bonner, Sachiko Hirosue, M. Swartz, J. Hubbell, O. Levy   +17 more
semanticscholar   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice

npj Vaccines, 2019
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis due to M. tuberculosis (Mtb), which kills millions of people each year. BCG variably protects children, but not adults against tuberculosis.
Arshad Khan, P. Bakhru, S. Saikolappan, K. Das, Emily Soudani, Christopher R. Singh, Jaymie L. Estrella, Dekai Zhang, Chandrashekhar Pasare, Yue Ma, Jianjun Sun, Jin Wang, R. Hunter, N. Eissa, S. Dhandayuthapani, C. Jagannath, C. Jagannath   +16 more
semanticscholar   +1 more source