Results 61 to 70 of about 389,087 (235)

Identification of Antigens Specific to Non-Tuberculous Mycobacteria: The Mce Family of Proteins as a Target of T Cell Immune Responses [PDF]

, 2011
The lack of an effective TB vaccine hinders current efforts in combating the TB pandemic. One theory as to why BCG is less protective in tropical countries is that exposure to non-tuberculous mycobacteria (NTM) reduces BCG efficacy.
Willem A Hanekom, Anna M Checkley, Wyllie, David H., Hill, Adrian, Thomas J Scriba, Hill Adrian V. S., Hanekom, Willem A., Thomas J. Scriba, McShane Helen, Hanekom Helen Mcshane, Willem A, Golubchik Tanya, Hanekom Willem A., Willem A. Hanekom, Hill, AV, Golubchik, Tanya, Anna M. Checkley, Helen McShane, Wyllie David H., Wyllie, DH, David H Wyllie, David H. Wyllie, Hanekom, WA, Scriba, Thomas J., Checkley Anna M., Scriba Thomas J., Hill, Adrian V. S., Scriba, TJ, Checkley, Anna M., Checkley, AM, Golubchik, T, Wyllie, David, Adrian V S Hill, Adrian V. S. Hill, Tanya Golubchik, McShane, H, McShane, Helen   +36 more
core   +1 more source

Immune System Development—Pro Tips for Paediatricians

Acta Paediatrica, EarlyView.
ABSTRACT There are many misconceptions about the immune system in children, its impact on infectious disease susceptibility and its role in the rapidly increasing rates of immune mediated diseases in industrialized societies. In this mini review, I will discuss common believes and the data supporting or countering such believes, with a focus on ...
Petter Brodin
wiley   +1 more source

Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining. [PDF]

, 2010
BACKGROUND: The vaccine efficacy reported following Mycobacterium bovis Bacillus Calmette Guerin (BCG) administration to UK adolescents is 77% and defining the cellular immune response in this group can inform us as to the nature of effective immunity ...
Natalie ER Beveridge, Rose Blitz, Steven G Smith, Blitz, R, Dockrell Hazel M, Smith, SG, Worth Andrew, Hazel M Dockrell, Smith, Steven G, McShane Helen, Maeve K Lalor, Gorak-Stolinska, Patricia, Helen McShane, Lalor, MK, Andrew Worth, Beveridge, NE, Blitz, Rose, Worth, A, Beveridge Natalie ER, Smith Steven G, Lalor Maeve K, Worth, Andrew, Gorak-Stolinska, P, Dockrell, HM, Gorak-Stolinska Patricia, Lalor, Maeve K, Dockrell, Hazel M, Beveridge, Natalie ER, Patricia Gorak-Stolinska, McShane, Helen, Blitz Rose   +30 more
core   +1 more source

A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA

Acta Paediatrica, EarlyView.
ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Tobias Alfvén, Tania Reza, Alieu Sowe
wiley   +1 more source

BCG vaccination: a role for vitamin D? [PDF]

, 2011
BCG vaccination is administered in infancy in most countries with the aim of providing protection against tuberculosis. There is increasing interest in the role of vitamin D in immunity to tuberculosis.
Hazel M. Dockrell, Rose Blitz, Branson Keith, Maeve K. Lalor, Blitz, R, Lalor Maeve K., Fine Paul E., Branson, K, Hazel M Dockrell, Maeve K Lalor, Floyd Sian, Fine, PE, Rosemary E Weir, Weir, RE, Gorak-Stolinska, Patricia, Rosemary E. Weir, Sian Floyd, Fine, Paul E, Lalor, MK, Floyd, Sian, Paul E. Fine, Blitz, Rose, Dockrell Hazel M., Weir, Rosemary E, Keith Branson, Paul E Fine, Weir Rosemary E., Gorak-Stolinska, P, Dockrell, HM, Gorak-Stolinska Patricia, Lalor, Maeve K, Dockrell, Hazel M, Branson, Keith, Patricia Gorak-Stolinska, Floyd, S, Blitz Rose   +35 more
core   +1 more source

Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG. [PDF]

PLoS ONE, 2009
BACKGROUND:In early clinical studies, the live tuberculosis vaccine Mycobacterium bovis BCG exhibited 80% protective efficacy against pulmonary tuberculosis (TB).
Shanmugalakshmi Sadagopal, Miriam Braunstein, Cynthia C Hager, Jie Wei, Alexandria K Daniel, Markian R Bochan, Ian Crozier, Nathaniel E Smith, Hiriam O Gates, Louise Barnett, Luc Van Kaer, James O Price, Timothy S Blackwell, Spyros A Kalams, Douglas S Kernodle   +14 more
doaj   +1 more source

Complex cytokine profiles induced by BCG vaccination in UK infants. [PDF]

, 2009
IFNgamma plays an important part in immunity to tuberculosis (TB), but although it is necessary, it is not on its own sufficient for protection against TB.
Fine, Paul E, Fine, Paul E., Hazel M. Dockrell, Dockrell, Hazel M., Floyd, Sian, Weir, Rosemary E., Paul E. Fine, Rose Blitz, Blitz, Rose, Maeve K. Lalor, Lalor, Maeve K., Steven G. Smith, Weir, Rosemary E, Smith, Steven G., Keith Branson, Smith, Steven G, Lalor, Maeve K, Dockrell, Hazel M, Gorak-Stolinska, Patricia, Rosemary E. Weir, Branson, Keith, Patricia Gorak-Stolinska, Sian Floyd   +22 more
core   +1 more source

Effectiveness Of BCG Vaccination in Prevention of Childhood Tuberculosis: A Prospective Study from Kishanganj, Bihar

National Journal of Community Medicine, 2013
Introduction: BCG vaccine has shown consistently high efficacy against childhood tubercular meningitis and miliary tuberculosis and other mycobacterial diseases. It is considered to be a safe vaccine with a low incidence of adverse effects.
Kashif Shahnawaz, Goutam Sarkar, Palash Das, Mausumi Basu, Biman Roy   +4 more
doaj  

Phylo-epidemiological and pathogenic diversity of Mycobacterium tuberculosis strains in London with implications for vaccine develpoment [PDF]

, 2010
PhDApproximately one-third of the global population is infected with tuberculosis causing approximately 1.7 million deaths. Currently, the BCG vaccine is used to protect against TB, but it cannot prevent primary infection or reactivation of latent ...
Velji, Preya
core   +4 more sources

Trained Immunity in Childhood Vaccination

Acta Paediatrica, EarlyView.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source