Results 81 to 90 of about 723,552 (238)

A Modified Bacillus Calmette-Guérin (BCG) Vaccine with Reduced Activity of Antioxidants and Glutamine Synthetase Exhibits Enhanced Protection of Mice despite Diminished in Vivo Persistence

Vaccines, 2013
Early attempts to improve BCG have focused on increasing the expression of prominent antigens and adding recombinant toxins or cytokines to influence antigen presentation.
Douglas S. Kernodle, Michael H. Cynamon, Hiriam O. Gates, Alexandria D. Allen, Miriam Braunstein, Kyi-Toe Tham, Carolyn M. Shoen, Michelle S. DeStefano, Cynthia C. Hager   +8 more
doaj   +1 more source

Adverse reactions to the Bacillus Calmette-Guérin (BCG) vaccine in new-born infants-an evaluation of the Danish strain 1331 SSI in a randomized clinical trial.

Vaccine, 2016
OBJECTIVE To evaluate adverse reactions of the Bacillus Calmette-Guérin (BCG) Statens Serum Institut (SSI) (Danish strain 1331) used as intervention in a randomized clinical trial.
T. Nissen, N. Birk, J. Kjærgaard, L. Thøstesen, G. Pihl, T. Hoffmann, D. Jeppesen, P. Kofoed, G. Greisen, C. Benn, P. Aaby, O. Pryds, L. Stensballe   +12 more
semanticscholar   +1 more source

Peritoneal Tuberculosis Presenting as Massive Ascites in Pregnancy: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Abdominal tuberculosis, especially peritoneal tuberculosis, is uncommon in pregnancy. The diagnosis during pregnancy is a challenge due to many signs and symptoms being nonspecific and mimicking the symptoms of pregnancy. The presence of ascites, with anorexia and weight loss in pregnancy from endemic regions, should be addressed with ...
S. Gyamtsho, S. Dechen, S. Choden
wiley   +1 more source

Vacina BCG contra tuberculose: efeito protetor e políticas de vacinação BCG vaccine against tuberculosis: its protective effect and vaccination policies

Revista de Saúde Pública, 2007
OBJETIVO: A vacina BCG é utilizada desde 1921, embora ainda apresente controvérsias e aspectos não esclarecidos. O objetivo do artigo foi analisar aspectos relacionados ao efeito protetor da primeira e segunda doses da vacina BCG e as políticas de ...
Susan M Pereira, Odimariles Maria Souza Dantas, Ricardo Ximenes, Mauricio L Barreto   +3 more
doaj   +1 more source

The potential impact of BCG vaccine supply shortages on global paediatric tuberculosis mortality

BMC Medicine, 2016
BackgroundThe Bacillus Calmette-Guérin (BCG) vaccine is provided to over 100 million neonates annually to protect against childhood tuberculosis (TB). Recent BCG manufacturing interruptions highlight global supply risks. We estimated the potential impact
R. Harris, P. Dodd, Richard G. White
semanticscholar   +1 more source

Associations of Inherited Chromosomally‐Integrated Human Herpesvirus 6 With Dementia Incidence, Inflammation, and Other Dementia Risk Factors in the UK Biobank

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT The infection theory of dementia states that viral infections and chronic inflammation play a role in its pathogenesis. We aimed to test whether testing positive for inherited chromosomally‐integrated human herpesvirus 6 (iciHHV‐6) is associated with an increased dementia incidence, inflammation, and other dementia risk factors. We included n =
Zhong Qiya, Marko Mandic, Tim Waterboer, Xie Ruijie, Hermann Brenner, Ben Schöttker   +5 more
wiley   +1 more source

Culture conditions impact the protein expression profile of Mycobacterium bovis BCG strains Moreau and Pasteur

BMC Microbiology
Background The Bacille Calmette-Guérin (BCG) vaccine, developed in the early 20th century, remains the only widely approved prophylactic against tuberculosis (TB). It was derived from an attenuated strain of Mycobacterium bovis.
Paloma Rezende Corrêa, Marcos Gustavo Araujo Schwarz, Meydson Benjamim Carvalho Corrêa, Márcia Berrêdo-Pinho, Leila Mendonça-Lima   +4 more
doaj   +1 more source

Recombinant BCG: Innovations on an old vaccine. Scope of BCG strains and strategies to improve long lasting memory

Frontiers in Immunology, 2014
BCG (Bacille Calmette-Guérin), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against active TB in children, BCG has failed to protect adults against TB infection
Adeliane C da Costa, Sarah Veloso Nogueira, André eKipnis, Ana Paula eJunqueira-Kipnis   +3 more
doaj   +1 more source

Boosting efferocytosis in alveolar space using BCG vaccine to protect host against influenza pneumonia

PLoS ONE, 2017
Efferocytosis by alveolar phagocytes (APs) is pivotal in maintenance of lung homeostasis. Increased efferocytosis by APs results in protection against lethal acute lung injury due to pulmonary infections whereas defective efferocytosis by APs results in ...
S. Mukherjee, R. Subramaniam, Han Chen, A. Smith, S. Keshava, H. Shams   +5 more
semanticscholar   +1 more source

MetF‐Dependent Methionine Biosynthesis Is Required for Mycobacterium tuberculosis Survival and In Vivo Persistence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
MetF is essential for both in vitro and in vivo growth of Mycobacterium tuberculosis, whereas MetE, previously considered essential in vitro, is dispensable in vivo. Given the importance of methionine and folate metabolism as drug targets, MetF represents a promising candidate, highlighting the need for in vivo validation.
Ikue Tosa, Tomoki Kitahara, Katsuki Takebe, Masaaki Nakayama, Yuko Ito, Akihito Nishiyama, Shintaro Seto, Hotaka Kawai, Hiharu Inoue, Yuki Fukada, Yuki Nishiya, Hitoshi Nagatsuka, Takayuki Wada, Manabu Ato, Sohkichi Matsumoto, Naoya Ohara   +15 more
wiley   +1 more source