Results 81 to 90 of about 420,990 (225)

A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA

Acta Paediatrica, Volume 115, Issue 11, Page 2498-2504, November 2026.
ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Tobias Alfvén, Tania Reza, Alieu Sowe
wiley   +1 more source

Duration of Immunity against Mycobacterium bovis following Neonatal Vaccination with Bacillus Calmette-Guerin Danish: Significant Protection against Infection at 12, but Not 24, Months [PDF]

, 2012
Vaccination of neonatal calves with Mycobacterium bovis bacillus Calmette-Guerin (BCG) induces a significant degree of protection against bovine tuberculosis, caused by infection with virulent M. bovis.
McAulay, M., Hewinson, R. G., Thom, M. L., Villarreal-Ramos, B., Vordermeier, H. M., Clifford, D., Hope, J. C.; id_orcid   +6 more
core   +1 more source

A Modified Bacillus Calmette-Guérin (BCG) Vaccine with Reduced Activity of Antioxidants and Glutamine Synthetase Exhibits Enhanced Protection of Mice despite Diminished in Vivo Persistence

Vaccines, 2013
Early attempts to improve BCG have focused on increasing the expression of prominent antigens and adding recombinant toxins or cytokines to influence antigen presentation.
Douglas S. Kernodle, Michael H. Cynamon, Hiriam O. Gates, Alexandria D. Allen, Miriam Braunstein, Kyi-Toe Tham, Carolyn M. Shoen, Michelle S. DeStefano, Cynthia C. Hager   +8 more
doaj   +1 more source

Recombinant BCG: Innovations on an old vaccine. Scope of BCG strains and strategies to improve long lasting memory

Frontiers in Immunology, 2014
BCG (Bacille Calmette-Guérin), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against active TB in children, BCG has failed to protect adults against TB infection
Adeliane C da Costa, Sarah Veloso Nogueira, André eKipnis, Ana Paula eJunqueira-Kipnis   +3 more
doaj   +1 more source

Trained Immunity in Childhood Vaccination

Acta Paediatrica, Volume 115, Issue 11, Page 2402-2413, November 2026.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Vacina BCG contra tuberculose: efeito protetor e políticas de vacinação BCG vaccine against tuberculosis: its protective effect and vaccination policies

Revista de Saúde Pública, 2007
OBJETIVO: A vacina BCG é utilizada desde 1921, embora ainda apresente controvérsias e aspectos não esclarecidos. O objetivo do artigo foi analisar aspectos relacionados ao efeito protetor da primeira e segunda doses da vacina BCG e as políticas de ...
Susan M Pereira, Odimariles Maria Souza Dantas, Ricardo Ximenes, Mauricio L Barreto   +3 more
doaj   +1 more source

The whole genome sequence of Polish vaccine strain Mycobacterium bovis BCG Moreau

Microbiology Spectrum
Currently, tuberculosis immunoprophylaxis is based solely on Bacillus Calmette-Guérin (BCG) vaccination, and some of the new potential tuberculosis vaccines are based on the BCG genome. Therefore, it is reasonable to analyze the genomes of individual BCG
Katarzyna Krysztopa-Grzybowska, Jakub Lach, Maciej Polak, Dominik Strapagiel, Jaroslaw Dziadek, Marcin Olszewski, Aleksandra A. Zasada, Aniela Darlińska, Anna Lutyńska, Ewa Augustynowicz-Kopeć   +9 more
doaj   +1 more source

Proteomic profile of culture filtrate from the Brazilian vaccine strain Mycobacterium bovis BCG Moreau compared to M. bovis BCG Pasteur

BMC Microbiology, 2011
Background Bacille Calmette-Guerin (BCG) is currently the only available vaccine against tuberculosis (TB) and comprises a heterogeneous family of sub-strains with genotypic and phenotypic differences. The World Health Organization (WHO) affirms that the
Degrave Wim M, Castello-Branco Luiz RR, da Silva Renata F, Pereira Melissa P, Gomes Leonardo HF, Correa Paloma R, Kalume Dario E, Berrêdo-Pinho Marcia, Mendonça-Lima Leila   +8 more
doaj   +1 more source

Phylo-epidemiological and pathogenic diversity of Mycobacterium tuberculosis strains in London with implications for vaccine develpoment [PDF]

, 2010
PhDApproximately one-third of the global population is infected with tuberculosis causing approximately 1.7 million deaths. Currently, the BCG vaccine is used to protect against TB, but it cannot prevent primary infection or reactivation of latent ...
Velji, Preya
core   +2 more sources

BCG Vaccination and Tuberculosis in Japan.

Journal of Epidemiology, 2003
This paper summarizes Bacillus Calmette-Guerin (BCG) vaccination and revaccination policies in Japan, its cost-effectiveness, side effects, proposed selective vaccination strategy, and present tuberculosis situation in Japanese perspectives based on Medline database and other published reports.
Rahman, Mahbubur, Takahashi, Osamu, Goto, Masashi, Fukui, Tsuguya   +3 more
openaire   +3 more sources