Results 71 to 80 of about 34,105 (239)

Phylogenomic and epidemiological insights into two clinical Mycobacterium bovis BCG strains circulating in South Africa

International Journal of Infectious Diseases, 2019
Background: Mycobacterium bovis BCG is a live, attenuated tuberculosis vaccine. While the vaccine protects infants from tuberculosis, complications including disseminated infections have been reported following vaccination.
Lesedi Modipane, Oleg Reva, Beki Themba Magazi, John Francis Antiabong, John Osei Sekyere, Nontombi Marylucy Mbelle   +5 more
doaj   +1 more source

What Is the Significance of an Accelerated BCG Reaction in Children Living in Low Tuberculosis Incidence Countries?

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim In high tuberculosis (TB) incidence countries, accelerated Bacille Calmette–Guérin (BCG) reactions are considered markers of prior Mycobacterium tuberculosis exposure and may prompt investigation. Their significance in low‐incidence countries is unclear.
Widad Al Salmi, Niall Johnston, Emma Birrell, Adam W. Bartlett, Pamela Palasanthiran, Brendan J. McMullan, Phoebe C. M. Williams   +6 more
wiley   +1 more source

Co‐Coverage of Essential Interventions Across the Health System Continuum of Care for Improving Child Nutrition in Ethiopia

Maternal &Child Nutrition, EarlyView.
ABSTRACT This study aimed to assess the coverage of essential nutrition interventions delivered through the health system and explored the relationship between co‐coverage and child‐ and maternal‐level factors, household‐level factors, and access to healthcare facilities.
Alemnesh Petros, Meron Girma, Tsedey Moges, Alemayehu Hussen, Tadesse Kebebe, Meseret Woldeyohannes, Teshome Asefa, Daniel Abera, Yirgalem Tadesse, Getachew Tollera, Mesay Hailu, Arnaud Laillou, Stanley Chitekwe, Kaleab Baye, Ramadhani Noor, Masresha Tessema   +15 more
wiley   +1 more source

A Modified Bacillus Calmette-Guérin (BCG) Vaccine with Reduced Activity of Antioxidants and Glutamine Synthetase Exhibits Enhanced Protection of Mice despite Diminished in Vivo Persistence

Vaccines, 2013
Early attempts to improve BCG have focused on increasing the expression of prominent antigens and adding recombinant toxins or cytokines to influence antigen presentation.
Douglas S. Kernodle, Michael H. Cynamon, Hiriam O. Gates, Alexandria D. Allen, Miriam Braunstein, Kyi-Toe Tham, Carolyn M. Shoen, Michelle S. DeStefano, Cynthia C. Hager   +8 more
doaj   +1 more source

Health and Survival Impacts of Early Childhood Development Programmes: The Case of the Happy Child Programme in Brazil

Review of Development Economics, EarlyView.
ABSTRACT This paper adds to the growing evidence on the impacts of early childhood development (ECD) programming by examining one of the world's largest home visitation programmes, the Happy Child Programme in Brazil, and its impacts on child vaccination and preventable death rates.
Raquel Tebaldi, Franziska Gassmann, Bruno Martorano   +2 more
wiley   +1 more source

Screening vaccine formulations for biological activity using fresh human whole blood. [PDF]

, 2014
Understanding the relevant biological activity of any pharmaceutical formulation destined for human use is crucial. For vaccine-based formulations, activity must reflect the expected immune response, while for non-vaccine therapeutic agents, such as ...
Ha, Yukyung, Rahman, Nausheen, Brookes, Roger H, Aboutorabian, Sepideh, Brookes, Roger, Dockrell, Hazel, Smith, Steven G., Todryk, Stephen, Hasija, Manvi, Todryk, Stephen M, Smith, Steven G, Ausar, Salvador, Ausar, Salvador F, Dockrell, Hazel M, Hakimi, Jalil   +14 more
core   +1 more source

Culture conditions impact the protein expression profile of Mycobacterium bovis BCG strains Moreau and Pasteur

BMC Microbiology
Background The Bacille Calmette-Guérin (BCG) vaccine, developed in the early 20th century, remains the only widely approved prophylactic against tuberculosis (TB). It was derived from an attenuated strain of Mycobacterium bovis.
Paloma Rezende Corrêa, Marcos Gustavo Araujo Schwarz, Meydson Benjamim Carvalho Corrêa, Márcia Berrêdo-Pinho, Leila Mendonça-Lima   +4 more
doaj   +1 more source

Recombinant BCG: Innovations on an old vaccine. Scope of BCG strains and strategies to improve long lasting memory

Frontiers in Immunology, 2014
BCG (Bacille Calmette-Guérin), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against active TB in children, BCG has failed to protect adults against TB infection
Adeliane C da Costa, Sarah Veloso Nogueira, André eKipnis, Ana Paula eJunqueira-Kipnis   +3 more
doaj   +1 more source

Life Course Malaria Exposure and SARS‐CoV‐2 Seroepidemiology in Ugandan Adolescents: A Longitudinal Study Nested in a Birth Cohort

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background COVID‐19 has had major global health impacts, yet reported morbidity and mortality have been lower in Africa despite serological evidence of widespread infection. Malaria has been proposed as a potential modifier of susceptibility to and outcomes of SARS‐CoV‐2 infection.
Ludoviko Zirimenya, Doreen Nayebare, Claire Baine, Jacent Nassuuna, Milly Namutebi, Christopher Zziwa, Denis Nsubuga, Fred Kiwudhu, Florence Akello, Josephine Tumusiime, Gloria Oduru, Grace Kabami, Hellen Akurut, Rachel Nakyesige, Agnes Natukunda, Anne Wajja, Lawrence Lubyayi, Simon Kimuda, Gyaviira Nkurunungi, Jennifer Serwanga, Katie J. Doores, Emily L. Webb, Alison M. Elliott   +22 more
wiley   +1 more source

Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A [PDF]

, 2013
© 2013 Matsumiya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Helen McShane (80704), Pathan, Ansar A, Stylianou, E, Lang, Z, Stephanie A. Harris (429956), Elena Stylianou (292312), Matsumiya, Magali, Griffiths Kristin, Lang Zoe, McShane Helen, Meyer, Joel, Magali Matsumiya, Griffiths, Kristin, Zoe Lang (429954), Lang, Zoe, Ansar A Pathan, Meyer, J, Angela M. Minassian (345365), Magali Matsumiya (429952), Fletcher Helen, Harris, Stephanie A, Rowland Rosalind, Meyer Joel, Kristin Griffiths (429953), Joel Meyer, Harris, SA, McShane, H, Fletcher, Helen, McShane, Helen, Minassian, Angela M, Zoe Lang, Rowland, Rosalind, Matsumiya Magali, Minassian Angela M., Angela M Minassian, Kristin Griffiths, Pathan Ansar A., Joel Meyer (429955), Helen Fletcher, Harris Stephanie A., Rowland, R, Rosalind Rowland, Matsumiya, M, Pathan, AA, Fletcher, H, Minassian, AM, Helen Fletcher (249210), Rosalind Rowland (429957), Helen McShane, Griffiths, K, Elena Stylianou, Stephanie A Harris, Ansar A. Pathan (80697), Stylianou, Elena, Stylianou Elena   +54 more
core   +1 more source