Results 71 to 80 of about 57,515 (295)

Genomic variations associated with attenuation in Mycobacterium avium subsp paratuberculosis vaccine strains [PDF]

, 2013
BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) whole cell vaccines have been widely used tools in the control of Johne's disease in animals despite being unable to provide complete protection. Current vaccine strains derive from stocks
Bull, TJ, Greene, M, Linedale, R, McKendrick, IJ, Sales, J, Schock, A, Sharp, JM, Stevenson, K   +7 more
core   +1 more source

Identifying potentially suitable and accessible refugia to mitigate impacts of an emerging disease on a rare tree

Conservation Biology, EarlyView.
Abstract Identifying refugia from emerging threats is vital to ensure the persistence of rare and threatened species, but modeling habitat distribution for these species is challenging and the role of people in refuge management is rarely considered. Myrtle rust is an emerging infectious disease that represents a grave threat to the rare wetland tree ...
Sarah M. Herbert, Stephanie A. Tomscha, Hao Ran Lai, Rubianca Benavidez, Colan G. Balkwill, Pearl R. Ruston, Bethanna Jackson, Julie R. Deslippe   +7 more
wiley   +1 more source

A Modified Bacillus Calmette-Guérin (BCG) Vaccine with Reduced Activity of Antioxidants and Glutamine Synthetase Exhibits Enhanced Protection of Mice despite Diminished in Vivo Persistence

Vaccines, 2013
Early attempts to improve BCG have focused on increasing the expression of prominent antigens and adding recombinant toxins or cytokines to influence antigen presentation.
Douglas S. Kernodle, Michael H. Cynamon, Hiriam O. Gates, Alexandria D. Allen, Miriam Braunstein, Kyi-Toe Tham, Carolyn M. Shoen, Michelle S. DeStefano, Cynthia C. Hager   +8 more
doaj   +1 more source

The possible puzzles of BCG vaccine in protection against COVID-19 infection

The Egyptian Journal of Bronchology, 2021
Background The paper aimed to analyze and evaluate the present literature data on the clinical effectiveness of using the bacillus Calmette–Guérin (BCG) vaccine in protecting against the novel coronavirus disease 2019 (COVID-19).
Basheer Abdullah Marzoog, Tatyana Ivanovna Vlasova   +1 more
doaj   +1 more source

Intratumoural tigilanol tiglate in the multicentre treatment of equine sarcoids and cutaneous melanomas

Equine Veterinary Journal, EarlyView.
Abstract Background Intralesional chemotherapeutic administration represents an important treatment option for equine cutaneous neoplasia. Tigilanol‐tiglate (TT), a novel molecule extracted from Fontainea picrosperma, an Australian rainforest plant, is registered for intratumoural treatment of canine MCT, leading to rapid oncosis and tumour slough ...
Raphael Labens, Corey Saba, Jarred Williams, Anna Hollis, Jos Ensink, Eduard Jose‐Cunilleras, Mireia Jordana‐Garcia, Kerstin Bergvall, Mick Ruppin, Frank Condon, Caroline Spelta, Yvonne Elce, Thomas De Ridder, John Morton, Cassandra McGee, Paul Reddell   +15 more
wiley   +1 more source

Immunization with antigenic extracts of Leishmania associated with Montanide ISA 763 adjuvant induces partial protection in BALB/c mice against Leishmania (Leishmania) amazonensis infection [PDF]

, 2014
Background/Purpose: A proper adjuvant has a relevant role in vaccine formulations to generate an effective immune response. In this study, total Leishmania antigen (TLA) formulated with Montanide ISA 763 or R848 as adjuvants were evaluated as a first ...
Cargnelutti, Diego Esteban, Celedon, Verónica, Cuello Carrión, Fernando Darío, Garcia Bustos, Maria Fernanda, Morea, Gastón, Salomón, María Cristina, Scodeller, Eduardo   +6 more
core   +1 more source

Effectiveness Of BCG Vaccination in Prevention of Childhood Tuberculosis: A Prospective Study from Kishanganj, Bihar

National Journal of Community Medicine, 2013
Introduction: BCG vaccine has shown consistently high efficacy against childhood tubercular meningitis and miliary tuberculosis and other mycobacterial diseases. It is considered to be a safe vaccine with a low incidence of adverse effects.
Kashif Shahnawaz, Goutam Sarkar, Palash Das, Mausumi Basu, Biman Roy   +4 more
doaj  

Recombinant BCG: Innovations on an old vaccine. Scope of BCG strains and strategies to improve long lasting memory

Frontiers in Immunology, 2014
BCG (Bacille Calmette-Guérin), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against active TB in children, BCG has failed to protect adults against TB infection
Adeliane C da Costa, Sarah Veloso Nogueira, André eKipnis, Ana Paula eJunqueira-Kipnis   +3 more
doaj   +1 more source

First vaccination after birth: serious adverse events of Bacillus Calmette-Guérin (BCG) in real-world

Human Vaccines & Immunotherapeutics, 2022
The Bacillus Calmette-Guérin (BCG) vaccine is a free vaccine in China, and more than 300 million newborns have been vaccinated. Inevitably, the BCG vaccine will have some rare adverse events on the first day of life (24 hours after birth), but related ...
Jinmiao Lu, Xunjie Zhang, Hong Xu, Zhiping Li   +3 more
doaj   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source