Results 1 to 10 of about 199,551 (110)
Expression profile of Bcl‐2 family proteins in newly diagnosed multiple myeloma patients [PDF]
HemaSphereAntiapoptotic Bcl‐2 family proteins are involved in myeloma cell survival. To date, their expression in multiple myeloma (MM) patients has mostly been analyzed at the RNA level.
Cristina De Ramón +20 more
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Evaluation of Bax and BCL 2 Genes Polymorphisms in Iraqi Women with Breast Cancer [PDF]
Archives of Razi Institute, 2022 The present study aimed to examine the polymorphism -938C > A of BCL-2 gene and promoter -248G>A in the Bax gene, as well as their relationship with specific clinical-pathological characteristics, in patients with breast cancer.
H. F. S Al-Zubaidy +2 more
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Bcl-B: an “unknown” protein of the Bcl-2 family
Biology Direct, 2023 Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different cancer types.
N. V. Pervushin +2 more
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BMC Pharmacology and Toxicology, 2022 Background Breast cancer is one of the most common types of cancer in women worldwide. Anti-apoptotic activity of cancer cells is considered the main reason for drug resistance in BC which reduces the 5-year survival rate of patients and is still ...
Mandana AmeliMojarad +2 more
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Annals of Medicine, 2023 Background Multiple myeloma (MM) is an incurable malignancy. Venetoclax (VEN) shows a meaningful effect in MM patients who are relapsed or refractory (RR) to previous standard therapies.Objective This study aimed to assess the efficacy and safety of VEN ...
Wei He, Fang He, Huixian Hu
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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity
Nature Communications, 2023 Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53 triggers transcription-independent apoptosis through direct interactions with BCL-2 family proteins,
Hudie Wei +11 more
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Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. [PDF]
PLoS ONE, 2013 Migration and invasion of malignant cells are prerequisites for cancer progression and metastasis. The Bcl-2 family of proteins consists of about 25 members and has been extensively studied in the context of apoptosis.
Bruno Christian Koehler +9 more
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Evaluation of Bcl 2 and Ki 67 expression in Chronic Lymphocytic Leukemia .
مجلة كلية الطب, 2013 Background :Chronic lymphocytic leukemia (CLL) is a low-grade B-lineage lymphoid malignancy. Both Ki-67 which is a large nuclear protein associated with cell proliferation and Bcl-2 which is an anti-apoptotic protein which is associated with ...
Subh S. AL- Mudallal, Huda N. Jasim
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Frontiers in Oncology, 2019 Hepatocellular carcinoma (HCC) ranks among the most rapidly evolving cancers in the Western world. The majority of HCCs develop on the basis of a chronic inflammatory liver damage that predisposes liver cancer development and leads to deregulation of ...
Jens U. Marquardt +3 more
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Cells, 2020 The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is responsible for a cell’s fate. Due to the recognized relevance of this family in cancer progression and response to therapy, different efforts have made in recent years in ...
Simona D’Aguanno, Donatella Del Bufalo
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