Results 1 to 10 of about 408,548 (333)
Bcl-2 expression in rectal cancer Expressão da proteína bcl-2 no câncer de reto [PDF]
Arquivos de Gastroenterologia, 2006 BACKGROUD: Proteins involved in apoptosis process seem to play an important role in colorectal carcinogenesis AIM: To determine the prevalence of bcl-2 protein immunohistochemical expression and its relation with clinical and histopathological variables ...
Paulo C. Contu +2 more
doaj +6 more sources
Evaluation of Bax and BCL 2 Genes Polymorphisms in Iraqi Women with Breast Cancer [PDF]
Archives of Razi Institute, 2022 The present study aimed to examine the polymorphism -938C > A of BCL-2 gene and promoter -248G>A in the Bax gene, as well as their relationship with specific clinical-pathological characteristics, in patients with breast cancer.
H. F. S Al-Zubaidy +2 more
doaj +1 more source
Bcl-B: an “unknown” protein of the Bcl-2 family
Biology Direct, 2023 Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different cancer types.
N. V. Pervushin +2 more
doaj +1 more source
BMC Pharmacology and Toxicology, 2022 Background Breast cancer is one of the most common types of cancer in women worldwide. Anti-apoptotic activity of cancer cells is considered the main reason for drug resistance in BC which reduces the 5-year survival rate of patients and is still ...
Mandana AmeliMojarad +2 more
doaj +1 more source
Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity
Nature Communications, 2023 Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53 triggers transcription-independent apoptosis through direct interactions with BCL-2 family proteins,
Hudie Wei +11 more
doaj +1 more source
Annals of Medicine, 2023 Background Multiple myeloma (MM) is an incurable malignancy. Venetoclax (VEN) shows a meaningful effect in MM patients who are relapsed or refractory (RR) to previous standard therapies.Objective This study aimed to assess the efficacy and safety of VEN ...
Wei He, Fang He, Huixian Hu
doaj +1 more source
Oncogene, 1998 Bcl-2 family proteins serve as critical regulators of pathways involved in apoptosis, acting to either inhibit or promote cell death. Altered expression of these proteins occurs commonly in human cancers, contributing to neoplastic cell expansion by suppressing programmed cell death and extending tumor cell life span. Moreover, because chemotherapeutic
openaire +2 more sources
Evaluation of Bcl 2 and Ki 67 expression in Chronic Lymphocytic Leukemia .
مجلة كلية الطب, 2013 Background :Chronic lymphocytic leukemia (CLL) is a low-grade B-lineage lymphoid malignancy. Both Ki-67 which is a large nuclear protein associated with cell proliferation and Bcl-2 which is an anti-apoptotic protein which is associated with ...
Subh S. AL- Mudallal, Huda N. Jasim
doaj +1 more source
Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. [PDF]
PLoS ONE, 2013 Migration and invasion of malignant cells are prerequisites for cancer progression and metastasis. The Bcl-2 family of proteins consists of about 25 members and has been extensively studied in the context of apoptosis.
Bruno Christian Koehler +9 more
doaj +1 more source
OncoImmunology, 2012 Recent findings from our laboratory provide the first indication that overexpression of Bcl-2 in Eµ-myc transgenic cells enhances tumor immunosurveillance by inducing NKG2D ligands. Initial evidence suggests that this model is relevant to human patients. Thus, antitumor therapies that target Bcl-2 harbor the risk of reducing tumor immunogenicity.
Putz, Eva Maria +2 more
openaire +2 more sources