Results 11 to 20 of about 369,993 (297)

Computational study of the mechanism of Bcl-2 apoptotic switch [PDF]

Tokar T., Ulicny J., Computational study of the mechanism of Bcl-2 apoptotic switch, Physica A: Statistical Mechanics and its Applications, Volume 391, Issue 23, 1 December 2012, Pages 6212-6225, 2011
Programmed cell death - apoptosis is one of the most studied biological phenomenon of recent years. Apoptotic regulatory network contains several significant control points, including probably the most important one - Bcl--2 apoptotic switch. There are two proposed hypotheses regarding its internal working - the indirect activation and direct ...
Adams, Albeck, Angeli, Angeli, Antonsson, Bagci, Barkai, Bluthgen, Brunelle, Chen, Chen, Cheng, Chipuk, Cory, Cui, Delhalle, Desagher, Dlugosz, Duke, Dussmann, Eissing, Eissing, Elmore, Fell, Ferrell, Ferrell, Ferrell, Goldstein, Gross, Gulbins, Harrington, Hellwig, Hua, Huang, Hucka, Jozef Uličný, Kholodenko, Kim, Kinnally, A.B., Kitano, Kroemer, Kroemer, Kroemer, Kuwana, Kuwana, Kuwana, Leber, Legewie, Legewie, Letai, Luo, Luthi, M.S.J, Madesh, Martinez-Caballero, Mayer, Oliver, Ott, Peixoto, Ramsey, Rehm, Rehm, Ruffolo, Spencer, Strasser, Sun, Tait, Tan, Terrones, Tomáš Tokár, Tsujimoto, Tyson, Valentijn, Vaux, von Ahsen, Walensky, Willis, Willis   +76 more
arxiv   +3 more sources

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor. [PDF]

PLoS ONE, 2013
The anti-apoptotic Bcl-2 protein is the founding member and namesake of the Bcl-2-protein family. It has recently been demonstrated that Bcl-2, apart from its anti-apoptotic role at mitochondrial membranes, can also directly interact with the inositol 1 ...
Giovanni Monaco, Elke Decrock, Koen Nuyts, Larry E Wagner, Tomas Luyten, Sergei V Strelkov, Ludwig Missiaen, Wim M De Borggraeve, Luc Leybaert, David I Yule, Humbert De Smedt, Jan B Parys, Geert Bultynck   +12 more
doaj   +10 more sources

A surface groove essential for viral bcl-2 function during chronic infection in vivo. [PDF]

PLoS Pathogens, 2005
Antiapoptotic Bcl-2 family proteins inhibit apoptosis in cultured cells by binding BH3 domains of proapoptotic Bcl-2 family members via a hydrophobic BH3 binding groove on the protein surface.
Joy Loh, Qiulong Huang, Andrew M Petros, David Nettesheim, Linda F van Dyk, Lucia Labrada, Samuel H Speck, Beth Levine, Edward T Olejniczak, Herbert W Virgin   +9 more
doaj   +7 more sources

Boolean network-based model of the Bcl-2 family mediated MOMP regulation [PDF]

arXiv, 2012
Mitochondrial outer membrane permeabilization (MOMP) is one of the most important points, in majority of apoptotic signaling cascades. Decision mechanism controlling whether the MOMP occurs or not, is formed by an interplay between members of the Bcl-2 family.
Tokar, Tomas, Turcan, Zdenko, Ulicny, Jozef   +2 more
arxiv   +4 more sources

Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells [PDF]

, 2010
Inhibition or downregulation of Bcl-2 represents a new therapeutic approach to by-pass chemoresistance in cancer cells. Therefore, we explored the potential of this approach in breast cancer cells.
A Letai, AK Zimmermann, Cagri Bodur, D Moon, D Tian, Dilek Telci, DJ Stewart, Elif Damla Arisan, F Manero, FA Sinicrope, Huveyda Basaga, IJ Enyedy, J An, J Chen, J Skommer, J Yu, JC Reed, JD Lickliter, JI Okani, JL Wang, JL Wang, L Chen, L Ming, L Oliver, M Milella, Ozgur Kutuk, RK Srivastava, SW Lowe, Tugsan Tezil, X Pei, X Wang, XY Pei, Y Ling, Y Su, Z Liu   +34 more
core   +1 more source

Targeting BCL-2 regulated apoptosis in cancer [PDF]

, 2018
The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death ...
Campbell, Kirsteen J., Tait, Stephen W.J.   +1 more
core   +1 more source

Small molecule and peptide inhibitors of the pro-survival protein Mcl-1 [PDF]

, 2016
The ability of protein–protein interactions to regulate cellular processes in both beneficial and detrimental ways has made them obvious drug targets.
Beekman, Andrew, Howell, Lesley
core   +1 more source

Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy [PDF]

, 2017
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we demonstrated the presence of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-
Chen, Hui-Chen, Cheng, Emily H, Dong, Yiyu, Ganesan, Yogesh Tengarai, Han, Song, Hellmann, Matthew D, Hsieh, James J, Inoue-Yamauchi, Akane, Ishizawa, Kota, Jebiwott, Sylvia, Jeng, Paul S, Kim, Kwanghee, Kris, Mark G, Pietanza, Maria C   +13 more
core   +2 more sources

Potential mechanisms of resistance to venetoclax and strategies to circumvent it

BMC Cancer, 2017
Background Venetoclax (ABT-199), a first-in-class orally bioavailable BCL-2-selective inhibitor, was recently approved by the FDA for use in patients with 17p-deleted chronic lymphocytic leukemia who have received prior therapy.
Stephen K. Tahir, Morey L. Smith, Paul Hessler, Lisa Roberts Rapp, Kenneth B. Idler, Chang H. Park, Joel D. Leverson, Lloyd T. Lam   +7 more
doaj   +1 more source

Significance of Bcl-2 and Bcl-6 immunostaining in B-Non Hodgkin's lymphoma

Hematology Reports, 2011
The determination of prognosis for B-Non- Hodgkin’s lymphoma (NHL) is known to be related to the multiple differences in tumor cell biology. Bcl-2 and Bcl-6 are two markers linked to germinal center B cells.
Hanan Mohamed Mahmoud, Yasmin Nabil Elsakhawy   +1 more
doaj   +1 more source