Results 11 to 20 of about 21,908,236 (341)
Cancer Management and Research, 2018 Bibi Kulsoom,1 Tahir Sultan Shamsi,1 Nasir Ali Afsar,2,3 Zahida Memon,4 Nikhat Ahmed,4 Syed Nazrul Hasnain5 1National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan; 2Jinnah Medical and Dental College, Karachi, Pakistan ...
Kulsoom B +5 more
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Bcl-2 expression in rectal cancer Expressão da proteína bcl-2 no câncer de reto [PDF]
Arquivos de Gastroenterologia, 2006 BACKGROUD: Proteins involved in apoptosis process seem to play an important role in colorectal carcinogenesis AIM: To determine the prevalence of bcl-2 protein immunohistochemical expression and its relation with clinical and histopathological variables ...
Paulo C. Contu +2 more
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Expression profile of Bcl‐2 family proteins in newly diagnosed multiple myeloma patients [PDF]
HemaSphereAntiapoptotic Bcl‐2 family proteins are involved in myeloma cell survival. To date, their expression in multiple myeloma (MM) patients has mostly been analyzed at the RNA level.
Cristina De Ramón +20 more
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Oncogene, 1998 Bcl-2 family proteins serve as critical regulators of pathways involved in apoptosis, acting to either inhibit or promote cell death. Altered expression of these proteins occurs commonly in human cancers, contributing to neoplastic cell expansion by suppressing programmed cell death and extending tumor cell life span. Moreover, because chemotherapeutic
John C. Reed
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Evaluation of Bax and BCL 2 Genes Polymorphisms in Iraqi Women with Breast Cancer [PDF]
Archives of Razi Institute, 2022 The present study aimed to examine the polymorphism -938C > A of BCL-2 gene and promoter -248G>A in the Bax gene, as well as their relationship with specific clinical-pathological characteristics, in patients with breast cancer.
H. F. S Al-Zubaidy +2 more
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The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
Frontiers in Oncology, 2022 Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies.
Shan Qian +5 more
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BCL-2 protein family: attractive targets for cancer therapy
Apoptosis, 2022 Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members play important roles in controlling apoptotic cell death. Abnormal over-expression of pro-survival BCL-2 family members or abnormal reduction of pro-apoptotic BCL-
Deeksha Kaloni +3 more
semanticscholar +1 more source
Bcl-B: an “unknown” protein of the Bcl-2 family
Biology Direct, 2023 Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different cancer types.
N. V. Pervushin +2 more
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The BCL-2 Family Reunion [PDF]
Molecular Cell, 2010 B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways.
Tudor Moldoveanu +4 more
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Targeting BCL-2 in Cancer: Advances, Challenges, and Perspectives
Cancers, 2021 Simple Summary Apoptosis, a programmed form of cell death, represents the main mechanism by which cells die. Such phenomenon is highly regulated by the BCL-2 family of proteins, which includes both pro-apoptotic and pro-survival proteins.
Shirin Hafezi, M. Rahmani
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