Results 221 to 230 of about 21,951,536 (341)

Phytochemical baicalin potentially inhibits Bcl-2 and VEGF: an <i>in silico</i> approach. [PDF]

Front Bioinform
Sharma V, Gupta A, Singh M, Singh A, Chaudhary AA, Ahmed ZH, Khan SU, Rustagi S, Kumar S, Kumar S.   +9 more
europepmc   +1 more source

Protection of Retinal Ganglion Cells from Natural and Axotomy-Induced Cell Death in Neonatal Transgenic Mice Overexpressing bcl-2 [PDF]

, 1996
Lidia Bonfanti, Enrica Strettoi, Sabrina Chierzi, Maria Cristina Cenni, Xiu-Huai Liu, Jean‐Claude Martinou, Lamberto Maffei, Sylvia A. Rabacchi   +7 more
openalex   +1 more source

A Surface Plasmon Resonance‐Based Integrated Assay for Quantification and Glycosylation Characterization of Monoclonal Antibodies in Crude Heterogeneous Samples

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The rise in cancer, autoimmune, inflammatory, and infectious diseases in recent decades has led to a surge in the development of monoclonal antibodies (mAbs) therapies, now the most widely used family of biologics. To meet the growing global demand, biopharmaceutical industries are intensifying their production processes.
Ilona Metayer, Catherine Forest‐Nault, Julie Guimond, Simon Joubert, Olivier Henry, Yves Durocher, Gregory De Crescenzo, Jimmy Gaudreault   +7 more
wiley   +1 more source

Oyster shells water extract ameliorates propylthiouracil-induced goitre in rats via PI3K/AKT/Bcl-2 pathway. [PDF]

NPJ Sci Food
Zhang H, Ma Q, Wang W, Wang B, Liu J, Wang F, Hu Y, Chen L, Liu Y, Wang Q, Chen H.   +10 more
europepmc   +1 more source

Anti-apoptotic genes, bag-1 and bcl-2, enabled hybridoma cells to survive under treatment for arresting cell cycle.

, 1997
Satoshi Terada, Katsuyuki Fukuoka, Tetsuo Fujita, Tomoaki Komatsu, Shinichi Takayama, John C. Reed, Eiji Suzuki   +6 more
openalex   +2 more sources

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Downregulation of rRNA synthesis by BCL-2 induces chemoresistance in diffuse large B cell lymphoma. [PDF]

iScience
Rossi A, Mazzara S, Salemi D, Zanetti S, Sapienza MR, Orecchioni S, Talarico G, Falvo P, Davini A, Ceccarelli C, Motta G, Melle F, Tabanelli V, Agostinelli C, Trerè D, Penzo M, Corsini C, Baiardi E, Calleri A, Vitolo U, Bertolini F, Zinzani PL, Chiarle R, Tarella C, Pileri S, Derenzini E.   +25 more
europepmc   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Selective BCL-2 inhibitor triggers STING-dependent antitumor immunity via inducing mtDNA release. [PDF]

J Immunother Cancer
Zhang W, Pan X, Wang L, Li W, Dai X, Zheng M, Guo H, Chen X, Xu Y, Wu H, He Q, Yang B, Ding L.   +12 more
europepmc   +1 more source

Single‐component cationic polyethylenimine thermogel for sustained and localized gene delivery to combat multi‐drug resistant cancer

BMEMat, EarlyView.
A cationic thermogelling copolymer employing branched PEI‐25 kDa as the sole hydrophilic segment can be facilely complexed with plasmid by physical mixing in the sol phase. Spontaneous gelation is achieved via self‐assembly after injection due to physiological temperature. Sustained and localized release of plasmid from the cationic PEI‐thermogel leads
Qianyu Lin, Minting Liu, Lingjie Ke, Nicholas Wei Xun Ong, Joey Hui Min Wong, Cally Owh, Valerie Ow, Belynn Sim, Yi Jian Boo, Jason Y. C. Lim, Yunlong Wu, Xian Jun Loh   +11 more
wiley   +1 more source