Results 31 to 40 of about 369,993 (297)

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia [PDF]

, 2015
Several chemo-resistance mechanisms including the Bcl-2 protein family overexpression and constitutive activation of the PI3K/Akt/mTOR signaling have been documented in acute lymphoblastic leukemia (ALL), encouraging targeted approaches to circumvent ...
ALLEGRETTI, MATTEO, Bergamo, P, FOA, Roberto, Iacovelli, S, LICCHETTA, ROBERTO, Martelli, Am, Mccubrey, Ja, Milella, M, MIRABILII, SIMONE, RICCIARDI, Maria Rosaria, Rinaldo, C, TAFURI, Agostino, Zeuner, A   +12 more
core   +1 more source

The physical studies and interaction with anti-apoptotic proteins of 2-(bis(cyanomethyl)amino)-2-oxoethyl methacrylate molecule [PDF]

Condens. Matter Phys., 2019, vol. 22, No. 3, 33301, 2019
In this work 2-(bis(cyanomethyl)amino)-2-oxoethyl methacrylate (CMA2OEM) molecule has been characterized theoretically. First, the potential energy surface has been calculated to find the lowest energy state of the molecule. After the most stable state of the molecule, Mulliken atomic charge and nonlinear-optical properties were investigated.
arxiv   +1 more source

A Minimal Model of Signaling Network Elucidates Cell-to-Cell Stochastic Variability in Apoptosis [PDF]

PLoS ONE 5(8): e11930 (2010), 2010
Signaling networks are designed to sense an environmental stimulus and adapt to it. We propose and study a minimal model of signaling network that can sense and respond to external stimuli of varying strength in an adaptive manner. The structure of this minimal network is derived based on some simple assumptions on its differential response to external
arxiv   +1 more source

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain [PDF]

, 2016
The antiapoptotic protein BCL 2 is overexpressed in several cancers and contributes to prolonged cell survival and chemoresistance, lending itself as an excellent target for cancer therapy.
Anderson, Arkin, Beauchard, Campos, Case, Chiruvella, Cho, Cotter, Dai, Delft, el-Sherbeny, Fedorov, Ferri, Gross, Gutierrez-Puente, Hanada, Iyer, Karki, Kavitha, Kavitha, Kavitha, Khaw, Kirkin, Kitada, Kolluri, Konopleva, Kumar, Lin, Lotem, Marschitz, Mologni, Moorthy, Morris, Nambiar, Nedelkina, Niesen, Oakes, Pan, Pentimalli, Real, Reed, Rosen, Shahabuddin, Shangary, Sharma, Souers, Srivastava, Srivastava, Trott, Vaillant, Vedadi, Vogler, Wang, Wang, Wang, Willis, Wlodkowic, Zhai   +57 more
core   +1 more source

Targeting Antiapoptotic Bcl-2 Family Members with Cell-Permeable BH3 Peptides Induces Apoptosis Signaling, Death in Head, Neck Squamous Cell Carcinoma Cells

Neoplasia: An International Journal for Oncology Research, 2007
Head, neck squamous cell carcinomas (HNSCCs) are frequently characterized by chemotherapy, radiation resistance, by overexpression of Bcl-XL, an antiapoptotic member of the Bcl-2 protein family. In this report, we examined whether cell-permeable peptides
Rongxiu Li, Amanda L. Boehm, Michelle B. Miranda, Sanjeev Shangary, Jennifer R. Grandis, Daniel E Johnson   +5 more
doaj   +1 more source

Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. [PDF]

PLoS ONE, 2010
Autophagy is described to be involved in homeostasis, development and disease, both as a survival and a death process. Its involvement in cell death proceeds from interrelationships with the apoptotic pathway.
Muriel Priault, Erika Hue, Fanny Marhuenda, Paul Pilet, Lisa Oliver, François M Vallette   +5 more
doaj   +1 more source

Using a hydrogen-bond index to predict the gene-silencing efficiency of siRNA based on the local structure of mRNA [PDF]

Biochem Biophys Res Comms, vol.320 (2) 622 (2004), 2017
The gene silencing effect of short interfering RNA (siRNA) is known to vary strongly with the targeted position of the mRNA. A number of hypotheses have been suggested to explain this phenomenon. We would like to test if this positional effect is mainly due to the secondary structure of the mRNA at the target site.
arxiv   +1 more source

BCL-2 expression promotes immunosuppression in chronic lymphocytic leukemia by enhancing regulatory T cell differentiation and cytotoxic T cell exhaustion

Molecular Cancer, 2022
Background Chronic lymphocytic leukemia (CLL) results in increased susceptibility to infections. T cell dysfunction is not associated with CLL in all patients; therefore, it is important to identify CLL patients with T cell defects.
Lu Liu, Xianfeng Cheng, Hui Yang, Senlin Lian, Yuegen Jiang, Jinhua Liang, Xiao Chen, Suo Mo, Yu Shi, Sishu Zhao, Jianyong Li, Runqiu Jiang, Dong-Hua Yang, Yujie Wu   +13 more
doaj   +1 more source

Análise da correlação entre a expressão da p53 e do bcl-2 com o estadiamento e o prognóstico do adenocarcinoma colorretal [PDF]

, 2005
PURPOSE: To analyze the correlation between p53 and bcl-2 expression and colorectal adenocarcinoma staging and prognosis. METHODS: This was a retrospective series of 125 colorectal adenocarcinoma patients (67 women and 58 men; ages 30-87 years) who ...
Artigiani Neto, Ricardo, Goldenberg, Alberto, Lustosa, Suzana Angelica Silva, Matos, Delcio, Saad, Sarhan Sydney, Waitzberg, Angela Flávia Logullo   +5 more
core   +3 more sources

Evaluation of Bcl-2 as a marker for chronic kidney disease prediction in cats

Frontiers in Veterinary Science, 2023
Chronic kidney disease (CKD) is a frequent condition in elderly cats. Bcl-2 is linked to kidney disease through the processes of apoptosis and fibrosis.
Pattiya Pila, Phongsakorn Chuammitri, Phongsakorn Chuammitri, Prapas Patchanee, Kidsadagon Pringproa, Kakanang Piyarungsri, Kakanang Piyarungsri   +6 more
doaj   +1 more source