Results 31 to 40 of about 408,548 (333)
Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy [PDF]
, 2017 BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we demonstrated the presence of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-
Chen, Hui-Chen +13 more
core +2 more sources
Lack of correlation between expression of Epstein-Barr virus (EBV) latent membrane protein and bcl-2 oncoprotein in vivo [PDF]
, 1994 Aims - To evaluate whether there is any correlation between the expression of Epstein-Barr virus (EBV) latent membrane protein (LMP) and oncoprotein bcl-2 in the lymph node biopsy specimens of a Chinese patient with EBV-related reactive ...
Ho, FCS, Loke, SL, Srivastava, G, Tao, Q
core +2 more sources
Structural insights for selective disruption of Beclin 1 binding to Bcl-2
Communications Biology, 2023 Stimulation of autophagy could provide powerful therapies for multiple diseases, including cancer and neurodegeneration. An attractive drug target for this purpose is Bcl-2, which inhibits autophagy by binding to the Beclin 1 BH3-domain.
Yun-Zu Pan +4 more
doaj +1 more source
Cell, 2009 BCL-2 family proteins regulate apoptotic cell death. BCL-2 proteins localize to intracellular membranes such as endoplasmic reticulum and mitochondria, and some family members translocate from the cytoplasm to mitochondria following a cell death stimulus.
Hardwick, J. Marie, Youle, Richard J.
openaire +2 more sources
Neoplasia: An International Journal for Oncology Research, 2007 Head, neck squamous cell carcinomas (HNSCCs) are frequently characterized by chemotherapy, radiation resistance, by overexpression of Bcl-XL, an antiapoptotic member of the Bcl-2 protein family. In this report, we examined whether cell-permeable peptides
Rongxiu Li +5 more
doaj +1 more source
Expression of apoptosis regulating proteins p53 and bcl-2 in psoriasis
Indian Journal of Pathology and Microbiology, 2015 Background: Dysfunctional apoptosis has an important role in the development of several skin diseases. Psoriatic keratinocytes possess an enhanced ability to resist apoptosis, which might be one of the key pathogenetic mechanisms in psoriasis.
Nikhil Moorchung +3 more
doaj +1 more source
Cancer Biology & Therapy, 2004 Commentary to: Expression of Inducible Bcl-XS in Myeloid Leukemia: Compensatory Upregulation of Bcl-XL and Bcl-2 Prevents Apoptosis and Chemosensitization Frank Tacke, Frank C. Marini, III, Shourong Zhao, Teresa McQueen, Marina Konopleva, Peter P.
Jan, Schmidt-Mende, Boris, Zhivotovsky
openaire +2 more sources
Impact of L-carnitine and selenium treatment on testicular apoptosis in rats exposed to 2.45 GHz microwave energy [PDF]
, 2015 Objective: It has been suggested that electromagnetic radiation (EMR) by wireless devices (2.45 GHz) induces testicular apoptosis. We investigated if supplemental selenium (Se) and L-carnitine may reduce this adverse effect.
Comlekci, S. +5 more
core +1 more source
The p53–Bcl-2 connection [PDF]
Cell Death & Differentiation, 2006 The tumor suppressor p53 and the proto-oncogene Bcl-2 were two of the earliest identified cancer genes. Mutant p53 proteins were first discovered in transformed murine cell lines,1,2 whereas Bcl-2 translocations were first identified in human follicular lymphoma.3,4,5 Despite this shared cancer relevance, they were initially thought to have little else
M T, Hemann, S W, Lowe
openaire +2 more sources
Molecular Cancer, 2022 Background Chronic lymphocytic leukemia (CLL) results in increased susceptibility to infections. T cell dysfunction is not associated with CLL in all patients; therefore, it is important to identify CLL patients with T cell defects.
Lu Liu +13 more
doaj +1 more source