Results 91 to 100 of about 95,261 (258)

The hepatic sympathetic nerve plays a critical role in preventing Fas induced liver injury in mice [PDF]

, 2005
Background: Although previous studies have shown that the hepatic sympathetic nerve controls various physiological functions in the liver, the role of this nerve in liver injury has yet to be clarified.Aims: The purpose of this study was to elucidate the
Chida, Y, Kubo, C, Sudo, N, Takaki, A
core   +1 more source

Targeting Bcl-xL enhances the cytotoxicity of chemotherapeutics [PDF]

Cancer Biology & Therapy, 2008
Commentary to:Synergistic cytotoxicity of Bcl-xL inhibitor, gossypol and chemotherapeutic agents in non-Hodgkin’s lymphoma cellsZhi-Ming Li, Wen-Qi Jiang, Zhen-Yu Zhu, Xiao-Feng Zhu, Jun-Min Zhou, Zong-Chao Liu, Da-Jun Yang and Zhong-Zhen ...
openaire   +2 more sources

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

PROTAC-Mediated Dual Degradation of BCL-xL and BCL-2 Is a Highly Effective Therapeutic Strategy in Small-Cell Lung Cancer

Cells
BCL-xL and BCL-2 are validated therapeutic targets in small-cell lung cancer (SCLC). Targeting these proteins with navitoclax (formerly ABT263, a dual BCL-xL/2 inhibitor) induces dose-limiting thrombocytopenia through on-target BCL-xL inhibition in ...
Sajid Khan, Lin Cao, Janet Wiegand, Peiyi Zhang, Maria Zajac-Kaye, Frederic J. Kaye, Guangrong Zheng, Daohong Zhou   +7 more
doaj   +1 more source

JAK–STAT signalling shapes the NF‐κB response in CLL towards venetoclax sensitivity or resistance via Bcl‐XL

Molecular Oncology, 2023
Preventing or overcoming resistance to the Bcl‐2 inhibitor venetoclax is an emerging unmet clinical need in patients with chronic lymphocytic leukaemia (CLL).
Marco V. Haselager, Rachel Thijssen, Danique Bax, Demi Both, Francien De Boer, Simon Mackay, Julie Dubois, Clemens Mellink, Arnon P. Kater, Eric Eldering   +9 more
doaj   +1 more source

Bax Can Antagonize Bcl-XL during Etoposide and Cisplatin-induced Cell Death Independently of Its Heterodimerization with Bcl-XL [PDF]

Journal of Biological Chemistry, 1996
Bax, a member of the Bcl-2 family of proteins, has been shown to promote apoptosis while other members of the family, including Bcl-XL and Bcl-2, inhibit cell death induced by a variety of stimuli. The mechanism by which Bax promotes cell death is poorly understood. In the present report, we assessed the ability of Bax to antagonize the death repressor
P L, Simonian, D A, Grillot, R, Merino, G, Nuñez   +3 more
openaire   +2 more sources

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source

BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation

Cell Death and Disease
Mitotic catastrophe induced by prolonged mitotic arrest is a major anticancer strategy. Although antiapoptotic BCL2-like proteins, including BCL-XL, are known to regulate apoptosis during mitotic arrest, adaptive changes in their expression can ...
Chun Yin Yu, Tsz Kwan Yeung, Wai Kuen Fu, Randy Y. C. Poon   +3 more
doaj   +1 more source

Translocation of p53 to Mitochondria Is Regulated by Its Lipid Binding Property to Anionic Phospholipids and It Participates in Cell Death Control

Neoplasia: An International Journal for Oncology Research, 2010
p53, can regulate cell apoptosis in both transcription-dependent and -independent manners. The transcription-independent pathway was demonstrated by the translocation of p53 to mitochondria. Our study showed that p53 mitochondrial translocation was found
Ching-Hao Li, Yu-Wen Cheng, Po-Ling Liao, Jaw-Jou Kang   +3 more
doaj   +1 more source

BCL-W has a fundamental role in B cell survival and lymphomagenesis. [PDF]

, 2017
Compromised apoptotic signaling is a prerequisite for tumorigenesis. The design of effective therapies for cancer treatment depends on a comprehensive understanding of the mechanisms that govern cell survival.
Annette S. Kim, Barrett, Christine M. Eischen, Clare M. Adams, Gibson, Haldar, Jerald Z. Gong, John K. Choi, Lee, Placzek, Ramkrishna Mitra, Schmitz, Visco, Wang, Yang   +14 more
core   +2 more sources