Results 101 to 110 of about 244,838 (273)
Expression of antiapoptotic protein Bcl-xL in optogeneticaly stimulated hippocampal glutamatergic neurons [PDF]
, 2017 The anti-apoptotic protein Bcl-xl takes part in processes of neuroplasticity such as synaptogenesis and release of neurotransmitters. In this study dependence of Bcl-xL expression on neuron activity was analyzed by in vivo optogenetic activating of the ...
Дрозд, У. С.
core
Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models [PDF]
, 2020 Background: The multikinase inhibitor regorafenib, approved as second-line treatment for hepatocellular carcinoma (HCC) after sorafenib failure, may induce mitochondrial damage.
Boix i Ferrero, Loreto +11 more
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Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis [PDF]
, 2020 Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further.
Aasumets, Koit +26 more
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BMC Pharmacology and Toxicology, 2022 Background RNA-cleaving deoxyribozymes (DNAzymes) are catalytic deoxyribonucleic acid molecules that have become a promising new class of gene suppressors by binding and cleaving target mRNA.
Zhen Yu +6 more
doaj +1 more source
BCL-XL-regulated apoptosis in T cell development [PDF]
International Immunology, 1997 Thymocyte differentiation progresses through well-defined stages in which apoptosis is central to the selection of a functional TCR repertoire. In the present study, we explored the developmental effects of BCL-XL, a repressor of apoptosis. We found that endogenous BCL-XL is down-regulated by both positive and negative selection signals at the CD4+ CD8+
Debra T. Chao, Stanley J. Korsmeyer
openaire +3 more sources
BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo. [PDF]
PLoS ONE, 2014 Bcl-2 and Bcl-xL are critical regulators of apoptosis that are overexpressed in a variety of human cancers and pharmacological inhibition of Bcl-2 and Bcl-xL represents a promising strategy for cancer treatment.
Longchuan Bai +6 more
doaj +1 more source
Chemical Communications, 2019 BCL-XL, an anti-apoptotic BCL-2 family protein, plays a key role in cancer cell survival. However, the potential of BCL-XL as an anti-cancer target has been hampered by the on-target platelet toxicity because platelets depend on BCL-XL to maintain their ...
Xuan Zhang +6 more
semanticscholar +1 more source
PLoS Pathogens, 2023 Kaposi's Sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi's Sarcoma (KS), a highly vascularized tumor common in AIDS patients and many countries in Africa.
Lyndsey N Moore +4 more
doaj +1 more source
Molecular basis for the interplay of apoptosis and proliferation mediated by Bcl-xL:Bim interactions in pancreatic cancer cells [PDF]
, 2012 A major mechanism through which cancer cells avoid apoptosis is by promoting the association of anti-apoptotic members of the pro-survival Bcl-2 protein family (like Bcl-2 and Bcl-xL) with BH3 domain-only proteins (like Bim and Bid).
Abrol, Ravinder +3 more
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Targeting Bcl-xL enhances the cytotoxicity of chemotherapeutics [PDF]
Cancer Biology & Therapy, 2008 Commentary to:Synergistic cytotoxicity of Bcl-xL inhibitor, gossypol and chemotherapeutic agents in non-Hodgkin’s lymphoma cellsZhi-Ming Li, Wen-Qi Jiang, Zhen-Yu Zhu, Xiao-Feng Zhu, Jun-Min Zhou, Zong-Chao Liu, Da-Jun Yang and Zhong-Zhen ...
openaire +3 more sources