Results 101 to 110 of about 59,389 (246)

IAP Antagonists Selectively Eliminate Therapy‐Induced Senescent Cancer Cells via TNFα‐Independent Apoptosis

Cancer Science, EarlyView.
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, Koji Ando, Eiji Oki, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao   +7 more
wiley   +1 more source

Bcl-xL regulates radiation-induced ferroptosis through chaperone-mediated autophagy of GPX4 in tumor cells

Radiation Medicine and Protection
Objective: To investigate the role and the molecular mechanisms of apoptotic signaling in ferroptosis to regulate tumor radiosensitivity. Methods: Reactive oxygen species (ROS) and lipid peroxide levels were detected in Mouse embryonic fibroblasts(MEFs ...
Jing Han, Ruru Wang, Bin Chen, Feng Xu, Liangchen Wei, An Xu, Lijun Wu, Guoping Zhao   +7 more
doaj   +1 more source

Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance

Cell Reports, 2016
Anti-apoptotic BCL-2 family members bind to BH3-only proteins and multidomain BAX/BAK to preserve mitochondrial integrity and maintain survival. Whereas inhibition of these interactions is the biological basis of BH3-mimetic anti-cancer therapy, the ...
Jessie Pécot, Laurent Maillet, Janic Le Pen, Céline Vuillier, Sophie de Carné Trécesson, Aurélie Fétiveau, Kristopher A. Sarosiek, Florian J. Bock, Frédérique Braun, Anthony Letai, Stephen W.G. Tait, Fabien Gautier, Philippe P. Juin   +12 more
doaj   +1 more source

Mitophagy and Bip–PERK–eIF2α–ATF4 Axis‐Mediated ER Stress Mediate Miriplatin‐Loaded Liposome's Anti‐Colorectal Cancer Action

Cell Proliferation, EarlyView.
LMPt enters the cell mainly through caveolin‐mediated endocytosis, and then fuses with endosomes and lysosomes to deliver MPt to mitochondria and the endoplasmic reticulum to induce mitophagy based on the fusion of lysosomes and mitochondria, and endoplasmic reticulum stress and subsequent apoptosis via the Bip–PERK–eIF2α–ATF4 axis to exert an anti ...
Cong Zhao, Yuhan Qiu, Xiaowei Wang, Mengyan Wang, Li Liu, Xiaojun Zhao, Zixiang Gao, Rongguang Shao, Guimin Xia, Wuli Zhao   +9 more
wiley   +1 more source

Label‐free imaging of intracellular structures in living mammalian cells via external apodization phase‐contrast microscopy

The FEBS Journal, EarlyView.
External apodization phase‐contrast (ExAPC) microscopy enables label‐free visualization of diverse intracellular structures in living mammalian cells. By enhancing phase‐contrast imaging through optical apodization, ExAPC reveals fine subcellular details, such as lipid droplets and organelle contacts, without fluorescent labels.
Hiroshi Ohno, Takenori Nishimura, Kenta Kainoh, Yoshitaka Ohashi, Naoko Onodera, Mayuko Kano, Lay Nurhana Sari, Masato Masuda, Yoshiaki Tamura, Teppei Nishino, Yusuke Hayashi, Yusuke Yamamoto, Shin‐Ichiro Takahashi, Yuta Mishima, Yosuke Yoneyama, Yoshinori Takeuchi, Motohiro Sekiya, Takashi Matsuzaka, Takafumi Miyamoto, Hitoshi Shimano   +19 more
wiley   +1 more source

Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL

Nature Communications
Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved potency and ...
Digant Nayak, Dongwen Lv, Yaxia Yuan, Peiyi Zhang, Wanyi Hu, Anindita Nayak, Eliza A. Ruben, Zongyang Lv, Patrick Sung, Robert Hromas, Guangrong Zheng, Daohong Zhou, Shaun K. Olsen   +12 more
doaj   +1 more source

Bax mitochondrial relocation is linked to its phosphorylation and its interaction with Bcl-xL

Microbial Cell, 2016
The heterologous expression of Bax, and other Bcl-2 family members, in the yeast Saccharomyces cerevisiae, has proved to be a valuable reporter system to investigate the molecular mechanisms underlying their interaction with mitochondria.
David Garenne, Thibaud T. Renault, Stéphen Manon   +2 more
doaj   +1 more source

Cellular Morphometric Analysis (CellMorph)—a comprehensive imaging‐based tool for quantifying cellular phenotype heterogeneity and dynamics across biological processes

The FEBS Journal, EarlyView.
CellMorph is a groundbreaking tool that allows researchers to analyze multiple features from single cells, including cell size and shape, cytosolic staining and subcellular texture, nuclear staining, and morphometry. By evaluating images from both bright‐field and fluorescence microscopy, it also tracks changes in living cells during key processes such
Henrique Quaiato de Oliveira, Solon Andrades da Rosa, Luiza Cherobini Pereira, Laura Boose de Mendonça, Juliete Scholl, Fabrício Figueiró, Thais Cardoso Bitencourt, Davi Piovesan Echevarria, João Luiz Aldinucci Buzzo, Jessica Boschini D'Agostin, Danieli Rosane Dallemole, Carolina Oliveira, Fernanda Simas, Fernanda Saez‐Calazans, Débora Santos‐Sousa, Guido Lenz, Eduardo C. Filippi‐Chiela   +16 more
wiley   +1 more source

Thymic Stromal Lymphopoietin Interferes with the Apoptosis of Human Skin Mast Cells by a Dual Strategy Involving STAT5/Mcl-1 and JNK/Bcl-xL [PDF]

, 2019
Tarek Hazzan, Jürgen Eberle, Margitta Worm, Magda Babina   +3 more
openalex   +1 more source

Supplementary Figure S4 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells [PDF]

, 2023
Xinzhe Li, Bo Li, Zhenhong Ni, Peng Zhou, Bin Wang, Jintao He, Haojun Xiong, Fan Yang, Yaran Wu, Xilin Lyu, Yan Zhang, Yijun Zeng, Jiqin Lian, Fengtian He   +13 more
openalex   +1 more source