Results 111 to 120 of about 95,261 (258)
JEADV Clinical Practice, EarlyView.ABSTRACT Background As solid organ transplantation becomes more prevalent, more patients are living on long‐term immunosuppression, greatly increasing the risk of cutaneous squamous cell carcinoma (cSCC). Although significant improvements have been achieved in the treatment of cSCC, further studies are needed to identify the specific protein expression
William Murray +8 more
wiley +1 more source
Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity. [PDF]
, 2012 In several neuronal cell types, the small GTPase Rac is essential for survival. We have shown previously that the Rho family GTPase inhibitor Clostridium difficile toxin B (ToxB) induces apoptosis in primary rat cerebellar granule neurons (CGNs ...
Aktories, Klaus +7 more
core +2 more sources
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Following anterior cruciate ligament (ACL) reconstruction, enhancing hamstring tenocyte activity and minimizing apoptosis are critical for preventing graft failure and promoting ligamentization. This study investigated the therapeutic potential of extracellular vesicles (EVs) derived from a coculture of ACL remnant cells and bone marrow ...
Hon‐Lok Lo +5 more
wiley +1 more source
mRNA in exosomas as a liquid biopsy in non-Hodgkin Lymphoma: a multicentric study by the Spanish Lymphoma Oncology Group [PDF]
, 2017 Purpose: To determine the feasibility of mRNAs (C-MYC, BCL-XL, BCL-6, NF-κβ, PTEN and AKT) in exosomes of plasma as a liquid biopsy method for monitoring and prognostic evolution in B-cell lymphomas.
Cantos, Blanca +12 more
core +4 more sources
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo +8 more
wiley +1 more source
Functions of BCL-XL at the Interface between Cell Death and Metabolism
International Journal of Cell Biology, 2013 The BCL-2 homolog BCL-XL, one of the two protein products of BCL2L1, has originally been characterized for its prominent prosurvival functions. Similar to BCL-2, BCL-XL binds to its multidomain proapoptotic counterparts BAX and BAK, hence preventing the ...
Judith Michels +6 more
doaj +1 more source
Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system [PDF]
, 2013 It has long been recognized that the T-cell compartment has more CD4 helper than CD8 cytotoxic T cells, and this is most evident looking at T-cell development in the thymus.
Bains, Iren +3 more
core +1 more source
Significance of Bcl-xL in human colon carcinoma
World Journal of Gastroenterology, 2008 To investigate the clinical significance of Bcl-xL gene in the pathogenesis of human colon carcinoma.Fifty-six pair tissue samples from patients with colon cancer were collected, and protein level of the Bcl-xL gene was measured by immunohistochemistry method. The correlation of Bcl-xL expression with clinical index was evaluated.
You-Li, Zhang +5 more
openaire +2 more sources
ChemistryOpen, EarlyView.Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel +5 more
wiley +1 more source
The endoplasmic reticulum pool of Bcl-xL prevents cell death through IP3R-dependent calcium release
Cell Death DiscoveryApoptosis plays a role in cell homeostasis in both normal development and disease. Bcl-xL, a member of the Bcl-2 family of proteins, regulates the intrinsic mitochondrial pathway of apoptosis. It is overexpressed in several cancers.
Rudy Gadet +13 more
doaj +1 more source