Results 111 to 120 of about 45,247 (265)

3D‐cultured BMSC exosomes improve cerebral ischemia/reperfusion injury‐induced neuronal apoptosis by regulating the microglia polarization

BMEMat, EarlyView.
The study reveals that microglial activation significantly contributes to neuroinflammation following cerebral ischemia‐reperfusion injury. It demonstrates that utilizing GelMA hydrogel for three‐dimensional culture of bone marrow‐derived mesenchymal stem cells (BMSCs) enhances the efficacy of BMSC‐derived exosomes in regulating microglial polarization
Yuming Li, Hao Shang, Qiong Zhang, Xianyong Yin, Zihao Liu, Yuqing Fang, Kyubae Lee, Huayang Zhao, Zhihai Wang, Hongbo Zhao, Xiaofeng Wang, Shengjie Li, Shan Wang, Tao Xin   +13 more
wiley   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase [PDF]

, 2011
Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution.
Alavian, Kambiz N., Li, Hongmei, Collis, Leon P., Bonanni, Laura, Zeng, Lu, Sacchetti, Silvio, Lazrove, Emma, Nabili, Panah, Flaherty, Benjamin, Graham, Morven, Chen, Yingbei, Messerli, Shanta M., Mariggio, Maria A., Rahner, Christoph, McNay, Ewan, Shore, Gordon, Smith, Peter J. S., Hardwick, J. Marie, Jonas, Elizabeth A.   +18 more
core   +1 more source

Methods for Controlling Small GTPase Activity

ChemBioChem, EarlyView.
This concept highlights recent and emerging methods for controlling small GTPase activity, encompassing both small‐molecule‐based approaches and protein engineering strategies. The use of these approaches to advance the understanding of small GTPase function, current limitations, and future outlook is discussed.
Benjamin Faulkner, Yuchen He, Daniel Sitrin, Cliff I. Stains   +3 more
wiley   +1 more source

A Polyproline Type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein–Protein Interaction Implicated in Breast Cancer

ChemBioChem, EarlyView.
Benzoylurea scaffolds accurately mimic the side‐chain vectors of the i, i + 1/2, and i + 3 positions of polyproline type II helices, showing functional activity in the disruption of a protein–protein interaction implicated in breast cancer. Given the essential role of protein–protein interactions (PPIs) in cellular signaling pathways, their selective ...
James Luccarelli, Philip C. Simister, Andrew D. Hamilton, Stephan M. Feller, Sam Thompson   +4 more
wiley   +1 more source

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition

BMC Cancer, 2012
Background It has been shown in many solid tumors that the overexpression of the pro-survival Bcl-2 family members Bcl-xL and Mcl-1 confers resistance to a variety of chemotherapeutic agents.
Peddaboina Chander, Jupiter Daniel, Fletcher Steven, Yap Jeremy L, Rai Arun, Tobin Richard P, Jiang Weihua, Rascoe Philip, Rogers M Karen, Smythe W, Cao Xiaobo   +10 more
doaj   +1 more source

Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors [PDF]

, 2016
Apoptosis plays an essential role during brain development, yet the precise mechanism by which this pathway is regulated in the brain remains unknown.
Anton,, Deshmukh, Mohanish, McCoy, Eric, Moy, Sheryl S., Nakamura, Ayumi, Plestant, Charlotte, Smith, Ikuko, Smith, Spencer, Swahari, Vijay   +8 more
core   +2 more sources

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

The endoplasmic reticulum pool of Bcl-xL prevents cell death through IP3R-dependent calcium release

Cell Death Discovery
Apoptosis plays a role in cell homeostasis in both normal development and disease. Bcl-xL, a member of the Bcl-2 family of proteins, regulates the intrinsic mitochondrial pathway of apoptosis. It is overexpressed in several cancers.
Rudy Gadet, Lea Jabbour, Trang Thi Minh Nguyen, Olivier Lohez, Ivan Mikaelian, Philippe Gonzalo, Tomas Luyten, Mounira Chalabi-Dchar, Anne Wierinckx, Olivier Marcillat, Geert Bultynck, Ruth Rimokh, Nikolay Popgeorgiev, Germain Gillet   +13 more
doaj   +1 more source

Significance of Bcl-xL in human colon carcinoma

World Journal of Gastroenterology, 2008
To investigate the clinical significance of Bcl-xL gene in the pathogenesis of human colon carcinoma.Fifty-six pair tissue samples from patients with colon cancer were collected, and protein level of the Bcl-xL gene was measured by immunohistochemistry method. The correlation of Bcl-xL expression with clinical index was evaluated.
You-Li Zhang, Xiao-Yan Wang, Chong-Qiang Wang, Yu Fan, Ying Wu, Li-Qun Pang   +5 more
openaire   +3 more sources