Results 141 to 150 of about 45,247 (265)

TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic–ischemic brain injury via inhibition of caspases and AIF

Neurobiology of Disease, 2006
Systemic delivery of recombinant Bcl-xL fusion protein containing the TAT protein transduction domain attenuated neonatal brain damage following hypoxic ischemia (H–I).
Wei Yin, Guodong Cao, Michael J. Johnnides, Armando P. Signore, Yumin Luo, Robert W. Hickey, Jun Chen   +6 more
doaj  

Bcl-xL gain of function and p19ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms [PDF]

SummaryOverexpression of Bcl-xL, loss of p19ARF, and loss of p53 all accelerate Myc oncogenesis. All three lesions are implicated in suppressing Myc-induced apoptosis, suggesting that this is a common mechanism by which they synergize with Myc.
Dansen, Tobias B., Evan, Gerard I., Finch, Andrew, Hunt, Abigail, Prescott, Julia, Shchors, Ksenya, Soucek, Laura, Swigart, Lamorna Brown   +7 more
core   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing

Frontiers in Genetics, 2019
Apoptosis plays a vital role in cell homeostasis during development and disease. Bcl-x, a member of the Bcl-2 family of proteins, is a mitochondrial transmembrane protein that functions to regulate the intrinsic apoptosis pathway. An alternative splicing
Megan Stevens, Sebastian Oltean
doaj   +1 more source

The A3Adenosine Receptor Mediates Cell Spreading, Reorganization of Actin Cytoskeleton, and Distribution of Bcl-xL: Studies in Human Astroglioma Cells [PDF]

, 1997
Maria P. Abbracchio, Gabriella Rainaldi, Anna Maria Giammarioli, Stefania Ceruti, Roberta Brambilla, Flaminio Cattabeni, Daniela Barbieri, Claudio Franceschi, Kenneth A. Jacobson, Walter Malorni   +9 more
openalex   +1 more source

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition &Food Research, EarlyView.
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca   +4 more
wiley   +1 more source

Design, Synthesis, and In Silico Insights of new 4‐Piperazinylquinolines as Antiproliferative Agents against NCI Renal Cancer Cell Lines

ChemistryOpen, EarlyView.
A novel series of hybrid 4‐(4‐benzoylpiperazin‐1‐yl)‐6‐nitroquinoline‐3‐carbonitrile derivatives has been designed, synthetized and evaluated for anticancer properties on the NCI60 panel. Strong antiproliferative effects have been detected against renal cancer cells.
Gabriele La Monica, Alessia Bono, Federica Alamia, Annamaria Martorana, Antonino Lauria   +4 more
wiley   +1 more source

Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-κB [PDF]

, 1999
Anne Badrichani, Deborah Stroka, Guadalupe Bilbao, David T. Curiel, Fritz H. Bach, Christiane Ferran   +5 more
openalex   +1 more source

Evaluation of the Antioxidant, Anticancer, and Antibacterial Activities of Flower and Leaf Extracts of Chrysanthemum indicum

ChemistryOpen, EarlyView.
The tested methanolic extract of Chrysanthemum indicum flower and leaf is a rich source of bioactive molecules with significant antioxidant activity at low doses, potential anticancer effects at lower concentrations, and antimicrobial activities against Gram‐positive and Gram‐negative species, which is consistent with the plant's traditional ...
Tarad Abalkhail, Noorah A. Alkubaisi, Ibrahim M. Aziz, Mashail Fahad Alsayed, Hissah Abdulrahman Alodaini, Amal Saad AL‐Shenifi, Mohamed A. Farrag   +6 more
wiley   +1 more source

Crystal Structure of Rat Bcl-xL [PDF]

, 1997
Masaharu Aritomi, N. Kunishima, Naohiro Inohara, Yoshitomo Ishibashi, Shigeo Ohta, Kosuke Morikawa   +5 more
openalex   +1 more source