Results 141 to 150 of about 95,261 (258)

Bax mitochondrial relocation is linked to its phosphorylation and its interaction with Bcl-xL

Microbial Cell, 2016
The heterologous expression of Bax, and other Bcl-2 family members, in the yeast Saccharomyces cerevisiae, has proved to be a valuable reporter system to investigate the molecular mechanisms underlying their interaction with mitochondria.
David Garenne, Thibaud T. Renault, Stéphen Manon   +2 more
doaj   +1 more source

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, EarlyView.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

TKC‐MC: An Effective Strategy for Generating Heritable Heterozygous Mutations in Essential Genes in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT The CRISPR/Cas9 gene‐editing technology has been widely used in defining gene functions and crop improvement. However, some genes are essential for plant growth and development. Loss‐of‐function homozygous mutations in essential genes lead to plant death or sterility.
Meilian Xu, Lang Yan, Min Zhu, Zhitian Zhan, Hong Chen, Dantong Wang, Zhenping Zheng, Yujie Zhang, Lizhong Xiong, Yubing He   +9 more
wiley   +1 more source

Prolonged exposure to artificial light and carcinogenesis: A systematic review of oncostatic mechanisms associated with melatonin pathways

Photochemistry and Photobiology, EarlyView.
Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza, Jêmina Oliveira, Antônio Ferreira, Renan Lopes, Marli Cupertino   +4 more
wiley   +1 more source

Impact of CD19 CAR T‐Cell Therapy on Pathogen‐Specific Antibody Titers in Lymphoma Patients

Transplant Infectious Disease, EarlyView.
Patients with lymphoma undergoing CD19 CAR T‐cell therapy experience prolonged hypogammaglobulinemia and B‐cell aplasia. We investigate its impact on immunity against measles virus (MeV), mumps virus (MuV), rubella virus (RuV), varicella‐zoster virus (VZV), pneumococcal capsular polysaccharide, Haemophilus influenzae type B (Hib), and tetanus toxoid ...
Hayley Foy‐Stones, Nicola Gardiner, Ellen Walsh, Derek G. Doherty, Anthony M. McElligott, Chris Armstrong, Nina Orfali, Robert Henderson, Elisabeth Vandenberghe, Elizabeth Higgins, Tor Hervig, Allison Waters, Brendan Crowley, Elizabeth Groarke, Niall P. Conlon, Christopher L. Bacon   +15 more
wiley   +1 more source

Exploring the nexus: Clinical and physiological correlation between cardiovascular disease and colorectal cancer

Experimental Physiology, EarlyView.
Abstract Colorectal cancer (CRC) and cardiovascular disease (CVD) are leading causes of morbidity and mortality worldwide, traditionally studied as distinct pathologies. However, emerging evidence suggests a significant physiological and molecular overlap between these conditions, indicating that they might share common pathophysiological pathways. The
Mohamad Bashir, Ali Murtada, Matti Jubouri, Wael Awad, Ian Williams, Damian M. Bailey   +5 more
wiley   +1 more source

Ghrelin protects against cell death in myocardial ischaemia: Emerging role of microRNA

Experimental Physiology, EarlyView.
Abstract Acute myocardial infarction (MI) accelerates cardiomyocyte apoptosis, which underpins ventricular remodelling and dysfunction. The hormone ghrelin mitigates this remodelling, but the mechanisms remain unclear. Specific microRNAs (miRs) are key modulators and reliable biomarkers of early‐stage apoptosis.
Rajesh Katare, Jeffrey R. Erickson, Daryl O. Schwenke   +2 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Phosphodiesterase 3A modulators sensitize tumor cells to Bcl-xL and Bcl-2/Bcl-xL inhibitors

AbstractPhosphodiesterase 3A (PDE3A) modulators are emerging anticancer agents for tumors that co-express PDE3A and Schlafen 12 (SLFN12), promoting the formation of a cytotoxic PDE3A-SLFN12 complex. The effect correlates with PDE3A and SLFN12 expression levels.
Kirsi Toivanen, Astrid Murumägi, Agnieszka Wozniak, Karo Wyns, Chao-Chi Wang, Luna De Sutter, Mariliina Arjama, Nanna Merikoski, Sami Salmikangas, Omar Youssef, Jorma Isola, Olli Kallioniemi, Patrick Schöffski, Tom Böhling, Harri Sihto   +14 more
openaire   +1 more source