Results 141 to 150 of about 59,389 (246)

Anticancer Molecular Mechanisms of Phytosterols: An Updated Review on Clinical Trials

open access: yesFood Science &Nutrition, Volume 14, Issue 2, February 2026.
Phytosterols, a form of naturally occurring substance structurally related to cholesterol, have been getting considerable interest due to their possible anticancer properties. Phytosterols induce apoptosis, block the cell cycle, and abrogate the invasion and metastasis of cancer cells, offering a multi‐manifestation treatment of cancer.
Muhammad Shahbaz   +14 more
wiley   +1 more source

CRISPR Screens Identify PIK3C2A as a Novel Mediator of EGFR Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma

open access: yesHead &Neck, Volume 48, Issue 2, Page 486-495, February 2026.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) is a malignancy with poor prognosis and survival. While epidermal growth factor receptor (EGFR) is a known driver of HNSCC, EGFR inhibitors show limited efficacy as monotherapies, suggesting that effective combination therapies are needed.
Jiayu Wang   +13 more
wiley   +1 more source

Quiescent memory B cells in human peripheral blood co-express bcl-2 and bcl-xL anti-apoptotic proteins at high levels [PDF]

open access: bronze, 1998
Fabrice Bovia   +5 more
openalex   +1 more source

New cell lines expanding the diversity of Ewing sarcoma models

open access: yesInternational Journal of Cancer, Volume 158, Issue 3, Page 642-655, 1 February 2026.
What's new? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff   +13 more
wiley   +1 more source

HIV-Tat-mediated Bcl-XL delivery protects retinal ganglion cells during experimental autoimmune optic neuritis

open access: green, 2005
Ricarda Diem   +8 more
openalex   +2 more sources

Crystal Structure of Rat Bcl-xL [PDF]

open access: yesJournal of Biological Chemistry, 1997
Masaharu Aritomi   +5 more
openaire   +1 more source

Low Dose of IL‐2 Application for Graft‐Versus‐Host Disease Prophylaxis Following Haploidentical Stem Cell Transplantation

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Early low‐dose IL‐2 administration after haploidentical HSCT promotes the reconstitution of NK cells and regulatory T cells (Tregs), enhances their activation (CD122+, DNAM‐1+, NKG2D+, CD62L+), and increases plasma cytokines (IFN‐γ, TNF‐α, IL‐10, IL‐2).
Zheng‐Li Xu   +13 more
wiley   +1 more source

Paeonol Inhibits Cell Growth by Inducing Ferroptosis in Human Glioma Cells

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT Paeonol (PAE), a phenolic phytochemical derived from traditional Chinese medicinal plants, exhibits multifaceted pharmacological properties including demonstrated antitumor efficacy against hepatic, gastric, and breast carcinomas. However, its therapeutic potential in glioma remains unexplored.
Xin Li   +8 more
wiley   +1 more source

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