Results 151 to 160 of about 59,389 (246)

BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage [PDF]

, 2020
Kerstin Brinkmann, Paul Waring, Stefan Glaser, Verena C. Wimmer, Denny L. Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex R. D. Delbridge, Guillaume Lessène, Ian Smyth, Marco J. Herold, Gemma L. Kelly, Stephanie Grabow, Andreas Strasser   +14 more
openalex   +1 more source

Pathogenesis of Vitiligo: Integrating Immune and Non‐Immune Cell Crosstalk

The Journal of Dermatology, Volume 53, Issue 2, Page 188-199, February 2026.
ABSTRACT Vitiligo is an acquired autoimmune disease characterized by depigmented macules resulting from melanocyte loss. It is a complex multifactorial disorder in which genetic predisposition is combined with environmental factors; however, its detailed etiology remains unclear.
Shintaro Inoue
wiley   +1 more source

Lycium barbarum polysaccharides enhance testicular spermatogenesis in d‐galactose‐induced aging rats via calcium signaling

Andrology, Volume 14, Issue 2, Page 496-515, February 2026.
Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma, Chang Liu, Jing Pu, Ziyu Liu, Na Hu, Li Yang, Dongmei Chen, Hongmei Li, HuiMing Ma   +8 more
wiley   +1 more source

The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner

, 2010
Aslamuzzaman Kazi, Jiazhi Sun, Kenichiro Doi, Shen‐Shu Sung, Yoshinori Takahashi, Hang Yin, Johanna M. Rodriguez, Jorge Becerril, Norbert Berndt, Andrew D. Hamilton, Hong‐Gang Wang, Saı̈d M. Sebti   +11 more
openalex   +1 more source

Bcl‐2/Bcl‐xl inhibitor APG‐1252‐M1 is a promising therapeutic strategy for gastric carcinoma [PDF]

, 2020
Hanjie Yi, Miao‐Zhen Qiu, Luping Yuan, Qiuyun Luo, Wentao Pan, Suna Zhou, Lin Zhang, Xianglei Yan, Dajun Yang   +8 more
openalex   +1 more source

Identification of prokineticin‐2 as potential pharmacodynamic biomarker for overcoming doxorubicin resistance in multicellular breast cancer spheroids

British Journal of Pharmacology, Volume 183, Issue 3, Page 491-504, February 2026.
Background and purpose Despite advances in immunotherapy, doxorubicin (Dox) chemotherapy is still the irreplaceable first‐line therapy for solid tumours such as breast cancer. However, chemotherapy resistance is the major limiting factor, requiring the use of high doses of Dox to achieve the anti‐tumour actions, often leading to severe side effects ...
Martina Vincenzi, Amin Kremic, Nathalie N. Tscheiller, Po‐Yen Hsu, Michael W. Y. Chan, Roberta Lattanzi, Canan G. Nebigil   +6 more
wiley   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

BCL-2 and BCL-xL in Cancer: Regulation, Function, and Therapeutic Targeting. [PDF]

Int J Mol Sci
Silva JPN, Pinto B, Silva PMA, Bousbaa H.   +3 more
europepmc   +1 more source

Lipid Modulation of the Activator-Independent Membrane Insertion and Refolding of the Apoptotic Inhibitor Bcl-xL [PDF]

, 2019
Victor Vasquez Montes, Alexey S. Ladokhin   +1 more
openalex   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source