Pediatric Discovery, EarlyView.Phyllanthus urinaria L can alleviate cisplatin‐induced acute kidney injury by inhibiting inflammation, apoptosis and oxidative stress. ABSTRACT Acute kidney injury (AKI) is a prevalent and serious clinical challenge with limited specific treatments.
Qitong Guo +8 more
wiley +1 more source
Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2 [PDF]
, 1996 M Silva +5 more
openalex +1 more source
Precision Medical Sciences, EarlyView.Hypericin and Resveratrol can be proposed as beneficial accompanying reagents in cancer immunotherapy and retinoblastoma treatment. Abstract One of the detrimental features of retinoblastoma is highly invasiveness of this type of cancer; the ability to metastasize into distal organs even in the early stages. This phenomenon highlights the importance of
Fatemeh Shahriari +6 more
wiley +1 more source
Activation of the CPP32 Apoptotic Protease by Distinct Signaling Pathways with Differential Sensitivity to Bcl-xL [PDF]
, 1996 Péter Erhardt, Geoffrey M. Cooper
openalex +1 more source
IL‐21 Loading CaMnCO3 Vitality Backpacks Boost CAR‐T Cell Synergistic Immunotherapy
Small, EarlyView.This work designs CaMnCO3 nanoparticles loaded with IL‐21, which simultaneously alleviates the acidity and hypoxia of the tumor microenvironment, serving as vitality backpacks for CAR‐T cells. These nanoparticles consistently enhance the effectiveness of CAR‐T cell therapy against solid tumors in both low‐ and high‐dose infusion models by gradually and
Baihui Wang +16 more
wiley +1 more source
Translocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage [PDF]
, 2000 Surender Kharbanda +14 more
openalex +2 more sources
The Roles of Bcl-XL and Apopain in the Control of Erythropoiesis by Erythropoietin [PDF]
, 1997 Paul A. Gregoli, Maurice C. Bondurant
openalex +1 more source
Semaglutide to remodel mitochondrial dynamics and mitophagy balance for vascular dementia therapy
VIEW, EarlyView.The effects of semaglutide on IR, mitochondrial dynamics, and mitophagy in the hippocampus of BCAS mice after CCH. It was shown that semaglutide maintained the balance of mitochondrial dynamics and mitophagy by improving IR and passing through GLP‐1R/PI3K/Akt pathway, reduced hippocampal neuroinflammation and neuron loss, and thus promoted the recovery
Xiaoyan Yang +11 more
wiley +1 more source
The Gene That Encodes the Herpes Simplex Virus Type 1 Latency-Associated Transcript Influences the Accumulation of Transcripts (Bcl-x\u3csub\u3eL\u3c/sub\u3e and Bcl-x\u3csub\u3es\u3c/sub\u3e) That Encode Apoptotic Regulatory Proteins [PDF]
, 2003 The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-xL transcript versus the Bcl-xS transcript in Neuro-2A cells.
Henderson, Gail A. +5 more
core +3 more sources
Bax Can Antagonize Bcl-XL during Etoposide and Cisplatin-induced Cell Death Independently of Its Heterodimerization with Bcl-XL [PDF]
, 1996 Philip L. Simonian +3 more
openalex +1 more source