Results 181 to 190 of about 95,261 (258)

Network‐based allosteric analysis of galectin‐7: Key residues dictate functional communication and stability

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Allosteric modulation enables precise control of protein activity but remains difficult to harness for selective inhibitor design. Traditional high‐throughput screening for allosteric modulators is still costly and time‐consuming, underscoring the need for predictive computational approaches.
N. T. Hang Pham, Alex Paré, Myriam Létourneau, Marlène Fortier, David Chatenet, Yves St‐Pierre, Patrick Lagüe, Charles Calmettes, Nicolas Doucet   +8 more
wiley   +1 more source

PROTAC-mediated degradation of Bcl-xL potentiates target therapy in preclinical melanoma models. [PDF]

J Exp Clin Cancer Res
Valentini E, Gentile G, Di Martile M, D'Aguanno S, Brignone M, Di Stefano AM, Di Caprio M, Melucci E, Botti C, Pelle F, Ortolano A, Fattore L, Mancini R, Ciliberto G, Rotili D, Del Bufalo D.   +15 more
europepmc   +1 more source

Covalent Peptide‐Based N‐Myc/Aurora‐A Inhibitors Bearing Sulfonyl Fluoride Warheads

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
N‐Myc‐derived peptidomimetics bearing aryl sulfonyl fluoride warheads were shown to act as effective N‐Myc/Aurora‐A PPI inhibitors, selectively labelling Aurora‐A in a recognition‐directed manner. ABSTRACT Orthosteric inhibition of the N‐Myc/Aurora‐A protein–protein interaction (PPI) represents a potential mechanism by which degradation of N‐Myc can be
Robert S. Dawber, Diana Gimenez, George W. Preston, Megan H. Wright, Richard Bayliss, Stuart L. Warriner, Andrew J. Wilson   +6 more
wiley   +1 more source

Targeting Bcl-xL to eliminate chemotherapy-induced tumor dormancy and prevent breast cancer metastasis. [PDF]

Br J Cancer
Gupta K, Koelsch N, Neely V, Graham L, Bear HD, Idowu MO, Harada H, Manjili MH.   +7 more
europepmc   +1 more source

Effects of Autophagy Inhibition by SAR405, a Selective VPS34 Inhibitor, on Pleural Mesothelioma Cells

Thoracic Cancer, Volume 17, Issue 5, March 2026.
SAR405, a selective VPS34 inhibitor, suppressed autophagic flux and reduced cell viability, colony formation, and invasion in pleural mesothelioma cell lines. SAR405 induced apoptosis only in H2452 cells. Cisplatin weakly induced autophagy, but its combination with SAR405 showed no synergistic cytotoxic effects. ABSTRACT Background Pleural mesothelioma
Yoshiki Kuwabara, Kosuke Sakai, Kota Shiraishi, Itsuka Matsumoto, Shigeru Ishii, Shin Yokosuka, Masatoshi Abe, Tomoyuki Takahashi, Yuichiro Kawano, Hiroaki Nishimura, Maiko Toda‐Sasaki, Yumiko Kobayashi‐Ogawa, Satoshi Kikuchi, Yusuke Hirata, Hiroyuki Kyoyama, Gaku Moriyama, Nobuyuki Koyama, Kazutsugu Uematsu   +17 more
wiley   +1 more source

Bcl-xL inhibition potentiates interferon-induced apoptosis in MPN stem cells. [PDF]

Blood Adv
Bywater MJ, Haldar R, Janardhanan Y, Cooper E, Cooper L, Chan SHN, Hayes N, Ling V, Straube J, Lane SW.   +9 more
europepmc   +1 more source

DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment

Aging Cell, Volume 25, Issue 3, March 2026.
We found very little overlap between CpGs that were correlated with in vitro senescence, chronological age, and mortality. While we were able to train epigenetic clocks with CpGs that accelerated with cellular senescence, these clocks did not decelerate with Senolytic treatment. ABSTRACT Epigenetic clocks are commonly used aging biomarkers based on DNA
Jessica Kasamoto, John González, Yaroslav Markov, Raghav Sehgal, Edwin Lee, Varun B. Dwaraka, Ryan Smith, Albert T. Higgins‐Chen   +7 more
wiley   +1 more source

Decoding Senescence‐Driven Heterogeneity in Early‐Onset Colorectal Cancer for Prognostic and Therapeutic Stratification

Cancer Science, Volume 117, Issue 3, Page 818-835, March 2026.
We uncovered pronounced and heterogeneous tumor senescence in EOCRC, independent of age. By integrating multi‐omics and single‐cell analyses, we developed EO‐Senscore, a prognostic tool that stratifies patients by immune phenotype and therapy response, enabling precision treatment using immunotherapy or senolytic agents. ABSTRACT Early‐onset colorectal
Du Cai, Mingru Mai, Rende Huang, Haoning Qi, Xingzhi Feng, Qianling Gao, Yinmeng Zhang, Chenghang Li, Xiaojian Wu, Yize Mao, Zihuan Yang, Feng Gao   +11 more
wiley   +1 more source

Circ-104792/miR-133a/Bcl-xL influences the proliferation and function of human trophoblastic and decidual stromal cells involved in recurrent abortion disease. [PDF]

Front Genet
Ma W, Ma Y, Zhu H, Shi P, Huang X, Yang Y.   +5 more
europepmc   +1 more source

Mitophagy and Bip–PERK–eIF2α–ATF4 Axis‐Mediated ER Stress Mediate Miriplatin‐Loaded Liposome's Anti‐Colorectal Cancer Action

Cell Proliferation, Volume 59, Issue 3, March 2026.
LMPt enters the cell mainly through caveolin‐mediated endocytosis, and then fuses with endosomes and lysosomes to deliver MPt to mitochondria and the endoplasmic reticulum to induce mitophagy based on the fusion of lysosomes and mitochondria, and endoplasmic reticulum stress and subsequent apoptosis via the Bip–PERK–eIF2α–ATF4 axis to exert an anti ...
Cong Zhao, Yuhan Qiu, Xiaowei Wang, Mengyan Wang, Li Liu, Xiaojun Zhao, Zixiang Gao, Rongguang Shao, Guimin Xia, Wuli Zhao   +9 more
wiley   +1 more source