Results 191 to 200 of about 95,261 (258)

Dual Bcl-2/Bcl-xl inhibition via AZD0466 combines with immune checkpoint blockade to enhance anti-tumour activity. [PDF]

Cell Death Dis
Newman DM, Andersen CL, Cluse LA, Newbold A, Fraser P, Legg BWC, Xu LK, Mele DA, Johnstone RW.   +8 more
europepmc   +1 more source

Regulation of Autophagy and Metabolism in Hepatocellular Carcinoma: Involvement of Wnt‐β‐Catenin Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Most cancer cells rely on aerobic glycolysis to support uncontrolled proliferation and evade apoptosis and switch to glutamine metabolism to survive under hypoxic conditions. In hepatocellular carcinoma (HCC), the Wnt/β‐catenin pathway acts as a critical driver of metabolic reprogramming and stemness, primarily by enhancing aerobic glycolysis ...
Sanjit K. Roy, Rashmi Srivastava, Nancy Landry, Shivam Srivastava, Anju Shrivastava, Rakesh K. Srivastava   +5 more
wiley   +1 more source

ODC1 Polyamine Metabolism Drives Prostate Cancer via AKT and Splicing

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Prostate cancer is an aggressive disease with limited quantifiable biomarkers. One gene of interest is ODC1, which encodes ornithine decarboxylase, the rate‐limiting enzyme converting ornithine to putrescine in polyamine metabolism. Although ODC1 is known to be involved in prostate cancer development, exactly how it drives the disease ...
Jian Ma, Ting Pan, Shengli Sun, Musitapa Mutalifu, Wei Yang, Yue Niu, Peng Chen   +6 more
wiley   +1 more source

Co-Targeting BCL-xL with MCL-1 Induces Lethal Mitochondrial Dysfunction in Diffuse Mesothelioma. [PDF]

Mol Cancer Ther
Xu Y, Medina CG, Surman DR, Dobrolecki LE, Vilchis M, Ramineni M, Hilsenbeck SG, Li Y, Li Y, Li N, Wu S, Aggison JC, Chen X, Zhu Y, Shen YH, Ripley RT.   +15 more
europepmc   +1 more source

Astrocyte Bioenergetic Remodeling as a Central Trait of Disrupted Glucocorticoid Signaling: Mechanisms and Implications for Stress Vulnerability

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Low/brief glucocorticoid (GC) elevations can enhance mitochondrial output (↑ oxygen consumption rate, OCR; ↑ mitochondrial membrane potential, ΔΨm) and Ca2+ buffering, in part via glucocorticoid receptor (GR) trafficking to mitochondria in complexes with Bcl2 and Bag1.
Paweł Hanus, Dorota Frydecka, Michał Ślęzak   +2 more
wiley   +1 more source

A2-pancortins interact with Bcl-xL and WAVE1 to promote mitochondria-ER contact sites (MERCs) and exacerbate mitochondrial calcium elevation to mediate cell death in stroke. [PDF]

Sci Rep
Yang Q, Wang CC, Matsuyama T, Kuroda K, Xie MJ, Yasumura M, Tsai CY, Oka Y, Yagi H, Sato M.   +9 more
europepmc   +1 more source

Functional Dissection of a Wheat NLR Protein Reveals a Minimal Active Region and Key Regulatory Sites for Immune Signalling

Molecular Plant Pathology, Volume 27, Issue 3, March 2026.
The coiled‐coil domain functions as the core signalling module of wheat NLRMoro, with residues 62–116 forming a minimal active region whose activity is fine‐tuned by intramolecular NBS and LRR regulation and key control sites. ABSTRACT Nucleotide‐binding site (NBS) leucine‐rich repeat (LRR) receptors (NLRs) are crucial for plant immunity but often come
Xiaoxu Zhu, Shuo Jiang, Jinchen Zhao, Fangfang Peng, Ran Zhao, Xinnuo Li, Yi Luo, Zhihao Xiong, Qi Li, Filip Rolland, Zhensheng Kang, Xiaojie Wang, Yunqi Liu, Li Huang, Xiaojing Wang   +14 more
wiley   +1 more source

First in human phase 1 study of DT2216, a selective BCL-xL degrader, in patients with relapsed/refractory solid malignancies. [PDF]

J Hematol Oncol
Mahadevan D, Barve M, Mahalingam D, Parekh J, Kurman M, Strauss J, Tremaine L, Hromas R, Sills J, McCulloch J, Harkey J, Suberg S, Zimmerman L, Zheng G, Zhou D.   +14 more
europepmc   +1 more source

Harnessing blue light photobiomodulation for cancer therapy: Evidence from a systematic review

Photochemistry and Photobiology, Volume 102, Issue 2, Page 370-399, March/April 2026.
Conventional treatments for various types of cancer are often associated with tumor recurrence and aggressiveness. Photobiomodulation with blue light (BL; 450–470 nm) emerges as a promising alternative with antitumor effects. This systematic review, with 37 in vitro and in vivo studies from 2002 to 2024, revealed that BL reduces cell viability ...
Bárbara Evelyn Santos de Lima, Rebeca Barros Nascimento, Ana Paula Mariano Santos Ginez, Maria Stella Moreira, Rebeca Boltes Cecatto, Rodrigo Labat Marcos, Maria Fernanda Setúbal Destro Rodrigues   +6 more
wiley   +1 more source

Antiapoptotic BCL2 family proteins BCL-XL and MCL1 as factors predicting resistance against venetoclax plus azacitidine for patients with newly diagnosed acute myelogenous leukemia. [PDF]

PLoS One
Kamihara Y, Kikuchi S, Ishikawa N, Shinomiya N, Kunimoto K, Horaguchi R, Fujihira T, Nabe Y, Minemura T, Ono K, Wada A, Dang NH, Sato T.   +12 more
europepmc   +1 more source