Results 201 to 210 of about 45,247 (265)

Formalin‐fixed paraffin‐embedded (FFPE) samples help to investigate transcriptomic responses in wildlife disease

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Infectious diseases impact numerous organisms. Knowledge of host‐pathogen interactions and host responses to infection is crucial for conservation and management. Obtaining this knowledge quickly is made increasingly possible by a variety of genomic approaches, yet, for many species the bottleneck to understanding this, remains access to ...
Allison K. Miller, Cara L. Brosnahan, Anjali Pande, Cindy F. Baker, Jemma L. Geoghegan, Jane Kitson, Neil J. Gemmell, Edwina J. Dowle   +7 more
wiley   +1 more source

Aven, a Novel Inhibitor of Caspase Activation, Binds Bcl-xL and Apaf-1 [PDF]

, 2000
B CHAU
openalex   +1 more source

Dual Targeting of Pim and PI3 Kinases in Mature T‐Cell Lymphoma

European Journal of Haematology, Volume 115, Issue 1, Page 82-95, July 2025.
ABSTRACT Provirus Integration site for Moloney leukemia virus (Pim) family members are well‐known oncogenes, with an expression that is restricted to few cell types including hematopoietic cells in adult organisms, making it a promising target for lymphoma treatment.
M. Lohrberg, M. Heber, L. Ries, K. Markus, N. Ksionsko, N. Schmidt, G. Nothnick, L. Thielking, M. O'Neill, S. Martínéz‐González, C. Blanco‐Aparicio, J. Pastor, D. Cunningham, R. Koch   +13 more
wiley   +1 more source

BCL-XL as a tumour prognostic factor?

Współczesna Onkologia, 2010
Jacek Wojcierowski, Szymon Zmorzyński, Agata Filip, Bożenna Kaczmarek-Borowska   +3 more
openaire   +2 more sources

The NF-κB Cascade Is Important in Bcl-xL Expression and for the Anti-Apoptotic Effects of the CD28 Receptor in Primary Human CD4+ Lymphocytes

, 2000
Ali Khoshnan, Charles Tindell, Isett Laux, D. Bae, Brydon L. Bennett, André E. Nel   +5 more
openalex   +1 more source

Heterodimerization of Bcl-2 and Bcl-XL with Bax and Bad in Colorectal Cancer [PDF]

, 2000
Nobuhiko Ookawa Takashi Hattori
openalex   +1 more source

MicroRNA‐100‐5p Exacerbates Myocardial Ischemia–Reperfusion Injury Through Downregulation of PRMT5

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
MiR‐100‐5p overexpression downregulates PRMT5, leading to increased PTEN activity and reduced AKT signaling. This molecular cascade promotes cardiomyocyte apoptosis, enhances fibrotic remodeling, and exacerbates cardiac dysfunction following myocardial ischemia–reperfusion injury.
Zhenya Wang, Tong‐You Wade Wei, Jo‐Mei Maureen Chen, Ke Zhang, Yiwei Zhang, Huiting Shi, Hsiang‐Chun Su, I‐Shan Hsieh, Chang‐Tze Ricky Yu, Guo‐Jun Zhao   +9 more
wiley   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, Volume 19, Issue 6, Page 1855-1875, June 2025.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

RAC2 Regulates the activation of akt and the balance between pro- and anti-apoptotic proteins bad and bcl-xl

, 2000
F-C Yang, Reuben Kapur, Alastair J. King, Tao Wen, Jovencio Borneo, Daniel Williams   +5 more
openalex   +1 more source

Overexpression of Bcl_XL in a human ovarian carcinoma cell line: Paradoxic effects on chemosensitivity in vitro versus in vivo [PDF]

, 2001
Paul Rogers, Philip Beale, Mansour Al‐Moundhri, Frances Boxall, Lisa Patterson, Melanie Valenti, Florence I. Raynaud, Steve Hobbs, Stephen Johnston, Lloyd R. Kèlland   +9 more
openalex   +1 more source