Results 221 to 230 of about 59,389 (246)

Parthenolide improves sepsis-induced coagulopathy by inhibiting mitochondrial-mediated apoptosis in vascular endothelial cells through BRD4/BCL-xL pathway. [PDF]

J Transl Med
Zhang J, Zhu X, Li Y, Wu Y, Du Y, Yang H, Liu Z, Pei H, Li R, Luo H, Zuo D, She H, Mao Q.   +12 more
europepmc   +1 more source

OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma. [PDF]

JCI Insight
Nguyen TT, Torrini C, Shang E, Shu C, Mun JY, Gao Q, Humala N, Akman HO, Zhang G, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD.   +13 more
europepmc   +1 more source

Reappraisal of the fundamental mechanisms of the sHA14-1 molecule as a Bcl-2/Bcl-XL ligand in the context of anticancer therapy: A cell biological study. [PDF]

J Biol Methods
Moustapha A, Andreu P, Gonzalvez F, Fradin D, Tissier JP, Diolez P, Petit PX.   +6 more
europepmc   +1 more source

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Bcl-xl Expression in Multiple Myeloma

Medical Oncology, 2005
In the present study the immunohistochemical expression of Bcl-xl, a downstream target of the IL-6-controlled signal transducer and activator of transcription-3 (Stat3) was studied in 40 multiple myeloma (MM) cases before treatment and 11 MM patients at relapse.
Peeters, SDPWM, Hovenga, S, Rosati, S, Vellenga, E   +3 more
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BCL-xL MD and PSN

2021
Collection of simulations and free energy calculations used in the publication Bcl-xL dynamics under the lens of protein structure networks. Valentina Sora, Dionisio Sanchez, Elena Papaleo*,J Phys Chem B, 2021, 125(17):4308-4320. doi: 10.1021/acs.jpcb.0c11562.
Tiberti, Matteo, Sora, Valentina, Papaleo, Elena, Cabrera, Dionisio Sánchez   +3 more
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Bcl-xL overexpression in human hepatocellular carcinoma

International Journal of Oncology, 2002
It is known that proliferation and apoptosis are closely related phenomena in liver cancer cells. In this study, using surgical specimens from 42 patients with hepatocellular carcinoma (HCC), we investigated the expression and localization of Bcl-xL, an antiapoptosis-related protein of the Bcl-2 family.
Jota, Watanabe, Fumiki, Kushihata, Kazuo, Honda, Katsumi, Mominoki, Seiji, Matsuda, Nobuaki, Kobayashi   +5 more
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BCL-xL Regulates Synaptic Plasticity

Molecular Interventions, 2006
Mitochondria are the predominant organelle within many presynaptic terminals. During times of high synaptic activity, they affect intracellular calcium homeostasis and provide the energy needed for synaptic vesicle recycling and for the continued operation of membrane ion pumps.
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BCL-XL directly retrotranslocates the monomeric BAK

Cellular Signalling, 2019
BCL-XL, an anti-apoptotic BCL-2 family protein, potently inhibits BAK oligomerization and the formation of toxic mitochondrial pores in response to cellular stress. This report aims to explore which form of mitochondrial monomeric and oligomerized BAK can be retrotranslocated by BCL-XL.
Bin Wang, Zihao Mai, Mengyan Du, Lu Wang, Fangfang Yang, Yunyun Ma, Xiaoping Wang, Tongsheng Chen   +7 more
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Sequence of Bcl-XL Antisense Oligonucleotides

Blood, 1999
To the Editor: In their report, Dibbert et al[1][1] had described that spontaneous eosinophil apoptosis was associated with a decrease in the levels of the antiapoptotic Bcl-XL protein. Because they also observed that granulocyte-macrophage colony-stimulating factor or interleukin-5 could ...
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Role of BCL-XL in Photoreceptor Survival

2008
Photoreceptors are post-mitotic neurons and understanding their survival mechanisms holds a key to the treatment of retinal degeneration. Many studies have demonstrated that phosphoinositide 3-kinase (PI3K) and its product phosphatidylinositol-3,4,5-trisphosphate (PIP3) are involved in the survival of neurons through growth factor receptor-mediated ...
Yun-Zheng, Le, Lixin, Zheng, Yuwei, Le, Edmund B, Rucker, Robert E, Anderson   +4 more
openaire   +2 more sources