Results 241 to 250 of about 45,247 (265)

Venetoclax Combined With Chemotherapy in Pediatric and Adolescent/Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, Volume 72, Issue 6, June 2025.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and although many patients respond to induction therapy, those who relapse or have refractory disease face a poor prognosis. Venetoclax has promising preclinical and clinical activity in ALL.
Andrew E. Place, Seth E. Karol, Christopher J. Forlenza, Todd M. Cooper, Christopher Fraser, Gunnar Cario, Maureen M. O'Brien, Nicolas U. Gerber, Jean‐Pierre Bourquin, Dirk Reinhardt, Jeffrey E. Rubnitz, Joseph T. Opferman, Gauri Sunkersett, Maika Onishi, Diana R. Dunshee, Xin Chen, Kristina Unnebrink, Deeksha Vishwamitra, Fengjiao Dunbar, Mohamed Badawi, Jeremy A. Ross, Mignon L. Loh   +21 more
wiley   +1 more source

GDNF Protects against Aluminum-Induced Apoptosis in Rabbits by Upregulating Bcl-2 and Bcl-XL and Inhibiting Mitochondrial Bax Translocation

, 2001
Othman Ghribi, Mary M. Herman, Michael S. Forbes, David A. DeWitt, John Savory   +4 more
openalex   +2 more sources

Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries

Smart Medicine, Volume 4, Issue 2, June 2025.
High uric acid‐induced vascular injuries are always accompanied with hyperuricemia, for which seeking for effective safety drugs is an urgent and crucial problem that needs to be solved. Here, we have successfully screened isoliquiritigenin out from multiplex traditional Chinese medicine monomers in promoting the repair of high uric acid‐induced ...
Hongyan Zhou, Xinyu Song, Yingying Tian, Lili Zhao, Jingyi Yang, Fangfu Ye, Ting Cao, Jiayu Zhang   +7 more
wiley   +1 more source

Bcl-XL translocation in renal tubular epithelial cells in vitro protects distal cells from oxidative stress

, 2001
Leila Cuttle, Xiaoju Zhang, Zoltán Endre, Clay Winterford, Glenda C. Gobé   +4 more
openalex   +1 more source

Comprehensive mapping of Arabidopsis alternative splicing landscape reveals key insights into plant development and immunity

The Plant Genome, Volume 18, Issue 2, June 2025.
Abstract The different steps of alternative splicing (AS) in plants and its regulatory mechanisms have already been studied extensively. Its broader impact on cell identity, plant immunity‐related genes, and their study as a whole remains to be investigated.
Teura Barff, Ingrid Berenice Sanchez Carrillo, Valeria Paola Parra Gutiérrez, Mélodie B. Plourde, David L. Joly, Hugo Germain   +5 more
wiley   +1 more source

Therapeutic Strategies for Relapsed or Refractory B‐Cell Acute Lymphoblastic Leukemia in Adult Patients: Optimizing the Use of Monoclonal Antibodies

European Journal of Haematology, Volume 114, Issue 6, Page 938-952, June 2025.
ABSTRACT The treatment landscape for relapsed or refractory acute lymphoblastic leukemia (RR ALL) has evolved significantly with the introduction of monoclonal antibodies such as blinatumomab and inotuzumab ozogamicin. These agents have demonstrated remarkable efficacy, achieving high response rates and minimal residual disease (MRD) negativity ...
Antonella Bruzzese, Enrica Antonia Martino, Caterina Labanca, Giulio Caridà, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Noemi Puccio, Antonino Neri, Fortunato Morabito, Ernesto Vigna, Massimo Gentile   +11 more
wiley   +1 more source

The Efficacy of Hellebrigenin Against Nasopharyngeal Carcinoma Cells: The Molecular and Bioinformatic Analysis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Nasopharyngeal carcinoma (NPC) is a unique cancer type originating from the nasopharynx. To investigate novel strategies for improving prognosis and reducing the adverse effects of current treatments, this study examined the efficacy of hellebrigenin.
Hsin‐Yu Ho, Mu‐Kuan Chen, Yun‐Jung Tsai, Chia‐Chieh Lin, Yu‐Sheng Lo, Yi‐Ching Chuang, Ming‐Ju Hsieh   +6 more
wiley   +1 more source

STAT3 Facilitates Super Enhancer Formation to Promote Fibroblast‐To‐Myofibroblast Differentiation by the Analysis of ATAC‐Seq, RNA‐Seq and ChIP‐Seq

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT A cellular characteristic of IPF is the transformation of fibrosis into myofibroblasts. This study identifies several transcription factors—STAT3, FOXP1, JUNB, ATF3, FosL2, BATF, Fra2 and AP‐1—that play crucial roles in promoting pulmonary fibrogenesis.
Yujie Wang, Yaqin Zhao, Guohong Cao, Mengqi Jiang, Xinglong Yuan, Hongbo Li, Xiaodong Song, Jinjin Zhang, Changjun Lv, Songzi Zhang   +9 more
wiley   +1 more source

The skeletal muscle response to high‐intensity training assessed by single‐nucleus RNA‐sequencing is blunted in individuals with type 2 diabetes

The Journal of Physiology, Volume 603, Issue 11, Page 3357-3377, 1 June 2025.
Abstract figure legend The figure illustrates the impact of high‐intensity interval training (HIIT) on skeletal muscle metabolism and insulin sensitivity in individuals with type 2 diabetes and healthy controls. HIIT consists of short bursts of intense exercise followed by rest periods.
Maria Hansen, Julius E. R. Grothen, Anders Karlsen, Jaime M. Martinez, Nikos Sidiropoulos, Jørn W. Helge, Thomas Å. Pedersen, Flemming Dela   +7 more
wiley   +1 more source

Glycoprotein 130 Regulates Cardiac Myocyte Survival in Doxorubicin-Induced Apoptosis Through Phosphatidylinositol 3-Kinase/Akt Phosphorylation and Bcl-xL/Caspase-3 Interaction

, 2001
Shinji Negoro, Hidemasa Oh, Eiroh Tone, Keita Kunisada, Yasushi Fujio, Kenneth Walsh, Tadamitsu Kishimoto, Keiko Yamauchi‐Takihara   +7 more
openalex   +1 more source