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Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 9, Issue S1, June 2025.
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Bcl-xl Expression in Multiple Myeloma

Medical Oncology, 2005
In the present study the immunohistochemical expression of Bcl-xl, a downstream target of the IL-6-controlled signal transducer and activator of transcription-3 (Stat3) was studied in 40 multiple myeloma (MM) cases before treatment and 11 MM patients at relapse.
Edo Vellenga, Susan D.P.W.M. Peeters, Stefano Rosati, Sjoerd Hovenga   +3 more
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Bcl-xL as an antiapoptotic molecule for cardiomyocytes

Drug News & Perspectives, 2003
It is now widely accepted that two forms of cell death, apoptosis and necrosis, occur in cardiomyocytes, and increasing evidence indicates that apoptosis plays an important role in the pathophysiology of cardiovascular diseases. Currently, two major pathways in the induction of apoptosis are known to occur in cardiomyocytes, the mitochondrial pathway ...
Yukiyo Ogata, Masafumi Takahashi
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BCL-xL MD and PSN

2020
Collection of simulations and free energy calculations used in the publication Bcl-xL dynamics under the lens of protein structure networks. Valentina Sora, Dionisio Sanchez, Elena Papaleo*,J Phys Chem B, 2021, 125(17):4308-4320. doi: 10.1021/acs.jpcb.0c11562.
Papaleo, Elena, Sora, Valentina, Cabrera, Dionisio, Tiberti, Matteo   +3 more
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Role of BCL-XL in Photoreceptor Survival

2008
Photoreceptors are post-mitotic neurons and understanding their survival mechanisms holds a key to the treatment of retinal degeneration. Many studies have demonstrated that phosphoinositide 3-kinase (PI3K) and its product phosphatidylinositol-3,4,5-trisphosphate (PIP3) are involved in the survival of neurons through growth factor receptor-mediated ...
Robert E. Anderson, Lixin Zheng, Yuwei Le, Edmund B. Rucker, Yun-Zheng Le   +4 more
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BCL-xL Regulates Synaptic Plasticity

Molecular Interventions, 2006
Mitochondria are the predominant organelle within many presynaptic terminals. During times of high synaptic activity, they affect intracellular calcium homeostasis and provide the energy needed for synaptic vesicle recycling and for the continued operation of membrane ion pumps.
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Sequence of Bcl-XL Antisense Oligonucleotides

Blood, 1999
To the Editor: In their report, Dibbert et al[1][1] had described that spontaneous eosinophil apoptosis was associated with a decrease in the levels of the antiapoptotic Bcl-XL protein. Because they also observed that granulocyte-macrophage colony-stimulating factor or interleukin-5 could ...
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Discovery and optimization of covalent Bcl-xL antagonists

Bioorganic & Medicinal Chemistry Letters, 2019
Over the last ten years, targeted covalent inhibition has become a key discipline within medicinal chemistry research, most notably in the development of oncology therapeutics. One area where this approach is underrepresented, however, is in targeting protein-protein interactions.
Neil P. Grimster, Brian Aquila, Joe Patel, Matthew A. Belmonte, Nancy Su, David J. Hargreaves, Sharon Tentarelli, Herschel Mukherjee   +7 more
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