Results 231 to 240 of about 145,113 (281)

A therapeutic-grade purified exosome system alleviates osteoarthritis by regulating autophagy through the BCL2-Beclin1 axis. [PDF]

J Nanobiotechnology
Zhao G, Yousefi F, Tsukamoto I, Moran S, Behfar A, Evans C, Zhao C.   +6 more
europepmc   +1 more source

Chronic Myeloid Leukemia Presenting With T‐Lymphoid Blast Crisis in a Young Female With Marked Hyperleukocytosis: A Case Report

eJHaem, Volume 7, Issue 2, April 2026.
Abstract Background Chronic myeloid leukemia (CML) presenting in blast crisis (BC) is uncommon in the era of tyrosine kinase inhibitor (TKI) treatment, and T‐lymphoblastic BC is exceptionally rare. We report a case of T‐lymphoid BC presenting with extreme hyperleukocytosis.
E. Somasundaram, R. P. Hasserjian, B. J. Aubrey, A. T. Fathi, H. Hock   +4 more
wiley   +1 more source

Detection of Structural Changes in G-Quadruplex-Forming DNA Oligonucleotides via DNA Methylation Based on Luminol Chemiluminescence Catalyzed by Myoglobin. [PDF]

Biosensors (Basel)
Inaba S, Kawai H, Tomizawa M, Miura D, Tsukakoshi K, Ikebukuro K.   +5 more
europepmc   +1 more source

Integrating Gene Expression With Recurrent Mutations Improves Age‐Stratified Risk Prediction in Acute Myeloid Leukemia

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Background Older adults with acute myeloid leukemia (AML) have inferior outcomes, yet current genetic risk models do not explicitly account for how age modifies the prognostic impact of molecular features. We hypothesized that integrating apoptosis and p53‐related gene expression with recurrent mutations would improve prediction of complete ...
Mobina Shrestha, Salina Dahal, Asis Shrestha, Patricia McNally, Amir Babu Shrestha, Niklas Mackler   +5 more
wiley   +1 more source

Venetoclax induces mitochondrial apoptosis and autophagy to overcome arsenic trioxide resistance in acute promyelocytic leukemia. [PDF]

J Transl Med
Dutta D, Maity A, Gupta SK, Gera P, Jain H, Bagal B, Chatterjee G, Rajpal S, Nayak L, Punatar S, Bandyopadhyay S, Chakraborty A, Chendamarai E, Balasundaram N, Gota V, Khattry N, Sengar M, Mathews V, Hasan SK.   +18 more
europepmc   +1 more source

Antimicrobial Peptides Induce Cell Death in Marginal Zone Lymphoma Models Resistant to Targeted Therapies

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Introduction Marginal zone lymphoma (MZL) is an indolent yet incurable B‐cell malignancy in which targeted agents such as BTK and PI3K inhibitors frequently fail due to resistance or toxicity. Antimicrobial peptides (AMPs), evolutionarily conserved effectors of innate immunity, possess selective cytotoxicity against malignant cells by ...
Filippo Spriano, Alberto J. Arribas, Fangwen Zhang, Elisa Civanelli, Maria Luisa Mangoni, Francesco Buonocore, Francesco Bertoni   +6 more
wiley   +1 more source

Novel therapeutic strategies targeting resistance mechanisms in hematologic malignancies: from BCL2 inhibition to immunomodulatory approaches. [PDF]

Front Pharmacol
Han Q, Jiang S, Chen J, Xue L.
europepmc   +1 more source

Epigenetic Regulation and Gene Expression Profiles in Cervical Swabs: Toward Non-Invasive Biomarkers of Cervical Lesion Progression. [PDF]

Epigenomes
Kašubová I, Hornáková A, Kotúľová L, Rokos T, Kolková Z, Kapinová A, Pribulová T, Kozubík E, Kalman M, Biringer K, Kúdela E, Holubeková V.   +11 more
europepmc   +1 more source

Evidence and Equity Gaps in Clinical Care of Chronic Lymphocytic Leukaemia in Portugal: A Real‐World, Multicentre, Cohort Study

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Objectives Targeted therapies have markedly improved outcomes in chronic lymphocytic leukaemia (CLL), particularly among patients with TP53 alterations and unmutated IGHV. However, real‐world studies report persistent inequalities in access to optimal care.
Susana Esteves, Inês Coelho, José Carda, Sara Duarte, Inês Carvalhais, Daniela Alves, Rita Coutinho, Maria Gomes da Silva   +7 more
wiley   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source