JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. [PDF]
, 2016 JMJD3 (Jumonji domain containing-3), a histone H3 Lys27 (H3K27) demethylase, has been reported to be involved in the antigen-driven differentiation of germinal center B-cells.
Bai, Nan +10 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2020 This review collects the data on DNA/RNA, the protein encoded and the diseases where BCL2L15 is involved. © 2020 Atlas of Genetics and Cytogenetics in Oncology and Haematology.
Artemaki, Pinelopi I +2 more
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Molecular evaluation of the anticancer potential of 1,3,4-oxadiazole-2-thiones derivative and its synergetic action with Nigella sativa seed extract (Thymoquinone) in experimentally induced Murine Lung Cancer Cell Line Model. [PDF]
Journal of Medical and Life ScienceLung cancer persistently poses as a primary factor in cancer-linked deaths globally, necessitating novel treatment strategies. This investigation appraises the anti-tumor potential of Thymoquinone (TQ) and 1,3,4-oxadiazole derivatives independently and ...
Abdel Aziz Zidane +3 more
doaj +1 more source
Targeting BCL-2 regulated apoptosis in cancer [PDF]
, 2018 The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death ...
Campbell, Kirsteen J. +1 more
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Oncoscience, 2015 The decision phase of apoptosis is mainly regulated by the Bcl-2 family, which renders these proteins potential targets for cancer therapy through apoptotic mechanisms. Bcl2 family members have homology clustered within four conserved Bcl2 homology (BH) domains (BH1, BH2, BH3 and BH4). Only the antiapoptotic proteins, such as Bcl2, Bcl-XL, Bcl-w and A1,
Guo, Chen, Xingming, Deng
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Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth. [PDF]
, 2015 Serine-threonine kinase CK2 is highly expressed and pivotal for survival and proliferation in multiple myeloma, chronic lymphocytic leukemia and mantle cell lymphoma.
Agostinelli, C +9 more
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Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP. [PDF]
, 2013 Important insights into nuclear function would arise if gene loci physically interacting with particular subnuclear domains could be readily identified.
Ahmed, Kashif +4 more
core +2 more sources
Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system [PDF]
, 2013 It has long been recognized that the T-cell compartment has more CD4 helper than CD8 cytotoxic T cells, and this is most evident looking at T-cell development in the thymus.
Bains, Iren +3 more
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Inverting the BTK-BCL2 order [PDF]
Blood, 2020 In this issue of Blood, Lin et al report the first long-term follow-up data showing that Bruton tyrosine kinase inhibitors (BTKi's) are effective in chronic lymphocytic leukemia (CLL) after previous progression on venetoclax.
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Avicenna Journal of Medicine, 2020 Background: CD10, BCL6, and MUM1 are commonly used immunohistochemical stains for classifying diffuse large B-cell lymphoma (DLBCL), which is useful in predicting outcome.
Feras Zaiem +6 more
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