Results 241 to 250 of about 35,489 (280)

Hi-C Technology Reveals Actionable Gene Fusions and Rearrangements in Diffuse Large B-Cell Lymphoma Unidentified by Conventional FISH. [PDF]

Genes (Basel)
Liang S, Ament C, Klausner M, Stinnett V, Morsberger L, Ghabrial J, Middlezong W, Schmitt AD, Hastie AR, Zou YS.   +9 more
europepmc   +1 more source

Defying the odds: A rare case of primary breast double-hit lymphoma with remarkable remission. [PDF]

SAGE Open Med Case Rep
Alsaket LZ, Elkourashy SA, Kolleri J, Alobadli AM.   +3 more
europepmc   +1 more source

The role of Bcl6 in mature cardiac myocytes [PDF]

Cardiovascular Research, 1999
The Bcl6 gene encodes a sequence-specific transcriptional repressor and is ubiquitously expressed in adult murine tissues including heart muscle. The objective of this study was to examine the role of Bcl6 in cardiac myocytes.We developed Bcl6-deficient (Bcl6-/-) mice and histologically examined hearts from these mice.Massive myocarditis with ...
Haruhiko Koseki, Masafumi Arima, Masaru Taniguchi   +2 more
exaly   +3 more sources

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BCL6 as a therapeutic target for lymphoma

Expert Opinion on Therapeutic Targets, 2018
B cell lymphoma 6 (BCL6) is a transcriptional repressor critical for the development and maintenance of germinal centers (GCs), which are required for generation of an effective humoral immune response. Genomic aberrations of BCL6, including mutations and translocations that occur during the GC reaction, as well as alterations of genes that regulate ...
Rebecca J, Leeman-Neill, Govind, Bhagat
openaire   +2 more sources

A-Miz-ing BCL6

Nature Immunology, 2005
Germinal center formation requires BCL6 to silence specific genes in B cells. New data now show that the repertoire of genes repressed by BCL6 is larger than previously thought, because of its interaction with the DNA-binding protein Miz-1.
Xiaosheng Wu, Diane F Jelinek
openaire   +1 more source

High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma

Blood, 2006
AbstractTo investigate the role of BCL6 in the pathogenesis of gastric lymphoma, we analyzed the BCL6 promoter region for BCL6 translocations, somatic hypermutations, and deregulating mutations in 43 gastric lymphomas, including 4 extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissues (MALT lymphomas), 33 diffuse large B-cell ...
Liang, AC, Chen, YW, Hu, XT, Au, WY, Wong, ML, Shen, L, Tao, Q, So, CC, Srivastava, G, Liang, RH, Kwong, YL, Chu, KM   +11 more
openaire   +4 more sources

Bcl6-dependent transcriptional repression by BAZF

Biochemical and Biophysical Research Communications, 2003
BAZF, a member of Bcl6 gene family, acts as a sequence-specific transcriptional repressor in various cells including NIH3T3 cells. The DNA-binding sequence for BAZF is the same as that for Bcl6 and the repressor activity of BAZF was also inhibited by Tricostatin A, an inhibitor of histone deacetylase, suggesting the functional homology between them ...
Masanori, Takenaga, Masahiko, Hatano, Mikio, Takamori, Yoshihiro, Yamashita, Seiji, Okada, Yoshikazu, Kuroda, Takeshi, Tokuhisa   +6 more
openaire   +2 more sources

Discovery of Potent and Selective BCL6 Ligand-Directed Degrader (LDD), BCL6-760

Journal of Medicinal Chemistry
The discovery of a potent and selective BCL6 ligand-directed degrader (LDD), BCL6-760 (45) is described. Through structure-activity relationships, the most potent heterobifunctional degraders of BCL6 were found to be those containing short aminopiperidine linkers in combination with an indazole-based cereblon (CRBN)-binding moiety (CBM).
Hunter P. Shunatona, Natalie Holmberg Douglas, Jayce Rhodes, William Thomas, Diogo Da Silva, Jim Gamez, Matt Groza, Andy Christoforou, Jinyi Zhu, Scott Johnson, Dharmpal Dodd, Dehua Huang, Jennifer Griffin, Giulianna Miseo, Brandon Whitefield, Dahlia Weiss, James Rader, Elif Kuzu, Jim Leisten, Joselyn Del Rosario, Lihong Shi, Mary Matyskiela, Philip P. Chamberlain, Peter Belmont, Matt Alexander, Christoph W. Zapf, Lynda Groocock, Deborah S. Mortensen   +27 more
openaire   +2 more sources