Results 251 to 260 of about 35,489 (280)

Acetylation inactivates the transcriptional repressor BCL6

Nature Genetics, 2002
The proto-oncogene BCL6 encodes a BTB/POZ-zinc finger transcriptional repressor that is necessary for germinal-center formation and has been implicated in the pathogenesis of B-cell lymphomas. Here we show that the co-activator p300 binds and acetylates BCL6 in vivo and inhibits its function.
Oksana R, Bereshchenko, Wei, Gu, Riccardo, Dalla-Favera   +2 more
openaire   +2 more sources

The role of BCL6 in lymphomas and routes to therapy

British Journal of Haematology, 2010
SummaryBCL6 is a transcription factor that has essential B‐cell and T‐cell roles in normal antibody responses. It is involved in chromosomal translocations in diffuse large B‐cell lymphoma (DBCL; including primary mediastinal B‐cell lymphoma) and nodular lymphocyte predominant Hodgkin lymphoma, and is expressed in follicular lymphoma and Burkitt's ...
Wagner, SD, Ahearne, M, Ko Ferrigno P
openaire   +3 more sources

Bcl2‐negative follicular lymphomas frequently have Bcl6 translocation and/or Bcl6 or p53 expression

Pathology International, 2007
Bcl2 is an important protein involved in the pathogenesis of follicular lymphoma (FL). However, approximately 10% of FL cases do not express Bcl2. The present study was designed to compare gene aberrations, prosurvival gene expression, apoptosis and proliferation rates in Bcl2‐positive and ‐negative FL cases.
Ying, Guo, Kennosuke, Karube, Riko, Kawano, Junji, Suzumiya, Morishige, Takeshita, Masahiro, Kikuchi, Gao-Sheng, Huang, Qing, Li, Koichi, Ohshima   +8 more
openaire   +2 more sources

The organization of the BCL6 gene.

Leukemia, 1994
The chromosomal translocation involving 3q27 has been recently described in B-cell malignancies, especially in diffuse large cell lymphomas. We have previously cloned the breakpoint cluster region of 3q27 designated as the BCL6 locus, previously known as BCL5, and subsequently cloned the cDNA for the BCL6 (we previously reported it as BCL5) gene ...
N, Kawamata, T, Miki, T, Fukuda, S, Hirosawa, N, Aoki   +4 more
openaire   +1 more source

BCL6 Inhibitors Exhibit Therapeutic Effects on Breast Cancer Cells through the BCL6-STAT4 Pathway

Anti-Cancer Agents in Medicinal Chemistry
Objective: This study aimed to explore the roles of BCL6 and STAT4 in breast cancer, their biological functions, and their relationships with the prognosis of patients with breast cancer. Methods: Online databases were used to analyze the expression characteristics of BCL6 and STAT4 in breast cancer, as well as the correlation between STAT4 and both
Zai, Wang, Mengtian, Tan, Junqi, Zhang, Hang, Ren, Xueshuai, Ye   +4 more
openaire   +2 more sources

Division of labor for oncogene BCL6

Blood, 2007
In this issue of Blood , Parekh and colleagues provide the first evidence that BCL6 uses different corepressor proteins for different functions. BCL6 requires the Mta3 corepressor to control B-cell differentiation, but not to control cell proliferation and survival.
openaire   +1 more source

BCL6 controls contact-dependent help delivery during follicular T-B cell interactions

Immunity, 2021
Dan Liu, Bo Liu, Ye Li
exaly  

PARP1 facilitates transcriptional activity and stability of the BCL6 protein and is a therapeutic target in BCL6 expressing lymphomas

Blood
Abstract BCL6, the “master regulator” of the Germinal Center (GC) reaction, is a transcriptional repressor implicated in lymphomagenesis. Determining BCL6 mechanisms of action is imperative for understanding GC biology, molecular mechanisms of lymphomagenesis and identifying novel therapeutic ...
XiaoQing Lu, Carolina Bañuelos, Lucas Caeiro, Poonam Yadav, Jessica Bouviere, Xiaoyu Jiang, Zhang Yu, Daniel Bilbao, Jennifer Chapman, Ramiro Verdun, Izidore S. Lossos   +10 more
openaire   +1 more source

BCL6

2010
Katia Basso, Riccardo Dalla-Favera
openaire   +1 more source

Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)

Trends in Immunology, 2021
Jinyong Choi, Shane Crotty
exaly