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ACS Medicinal Chemistry Letters
BCL6 overexpression drives lymphomagenesis and immune evasion in B-cell malignancies. This Patent Highlight presents novel bifunctional degraders targeting BCL6, demonstrating high potency and selectivity. These degraders induce BCL6 degradation via a PROTAC-based mechanism, resulting in apoptosis and tumor regression in BCL6-positive cancers.
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BCL6 overexpression drives lymphomagenesis and immune evasion in B-cell malignancies. This Patent Highlight presents novel bifunctional degraders targeting BCL6, demonstrating high potency and selectivity. These degraders induce BCL6 degradation via a PROTAC-based mechanism, resulting in apoptosis and tumor regression in BCL6-positive cancers.
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Roles of BCL6 in normal and transformed germinal center B cells
Immunological Reviews, 2012Katia Basso, Riccardo Dalla-Favera
exaly
BCL6 promotes glioma and serves as a therapeutic target
Proceedings of the National Academy of Sciences of the United States of America, 2017Liang Xu, Ye Chen, Anand Mayakonda
exaly
Endometrial BCL6 testing for the prediction of in vitro fertilization outcomes: a cohort study
Fertility and Sterility, 2017Ricardo F. Savaris +2 more
exaly
HindIII polymorphism in the BCL6 gene
Human Molecular Genetics, 1993B W, Baron +3 more
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