Results 181 to 190 of about 60,584 (224)

Essential thrombocythemia with BCR/ABL rearrangement

Cancer Genetics and Cytogenetics, 1996
Essential thrombocythemia (ET) was diagnosed clinically in three patients Karyotypic analysis and reverse transcription polymerase chain reaction for the bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive, bcr-abl positive, whereas the third was Ph negative, bcr-abl positive.
Kwong, YL, Chiu, EKW, Liang, RHS, Chan, V, Chan, TK   +4 more
openaire   +4 more sources

Osteopontin is upregulated by BCR-ABL

Biochemical and Biophysical Research Communications, 2005
Chronic myelogenous leukemia (CML) is characterized by its hallmark oncogene BCR-ABL and the progression from a chronic phase toward an acute leukemia, with a differentiation arrest of the leukemic clone. In the present study, we conducted a microarray analysis using an inducible model of BCR-ABL expression based on the TET-OFF system, and we found ...
S, Flamant, T, Kortulewski, A, Dugray, M-L, Bonnet, M, Guillier, F, Guilhot, J-H, Bourhis, W, Vainchenker, D, Tronik-Le Roux, A G, Turhan   +9 more
openaire   +2 more sources

Targeting of BCR-ABL: Lessons learned from BCR-ABL inhibition.

Cellular and molecular biology (Noisy-le-Grand, France), 2017
In 1960 researchers reported that balanced translocation between chromosomes 22 and 9 resulted in the generation of Philadelphia chromosome. This breakthrough revolutionized our knowledge related to leukemia biology and contemporary studies revealed that chromosomal translocation resulted in the fusion between the 5' segment of BCR gene and 3' segment ...
X, Lin, M Z, Qureshi, R, Attar, S, Khalid, F, Tahir, A, Yaqub, A, Aslam, I, Yaylim, L K, De Carlos Back, A A, Farooqi, M, Ismail   +10 more
openaire   +1 more source

BCR-ABL-negative chronic myeloid leukemia

Current Hematologic Malignancy Reports, 2007
Constitutive activation of protein tyrosine kinases plays a central role in the pathogenesis of myeloproliferative disorders, including BCR-ABL-negative chronic myeloid leukemia. Current research is focused on elucidating the full spectrum of causative mutations in this rare, heterogeneous disease.
Sonja, Burgstaller, Andreas, Reiter, Nicholas C P, Cross   +2 more
openaire   +2 more sources

BCR-ABL gene variants.

Bailliere's clinical haematology, 1997
The BCR-ABL hybrid gene, the main product of the t(9;22)(q34;q11) translocation, is found in the leukaemic clone of at least 95% of CML patients. The fusion protein encoded by BCR-ABL varies in size, depending on the breakpoint in the BCR gene. Three breakpoint cluster regions have been characterized to date: major (M-bcr), minor (m-bcr) and micro (mu ...
openaire   +2 more sources

The immunogenicity of Bcr-Abl–expressing dendritic cells is dependent on the Bcr-Abl kinase activity and dominated by Bcr-Abl–regulated antigens

Blood, 2007
In Ph+ chronic myeloid leukemia (CML), the constitutively active Bcr-Abl kinase leads to the up-regulation and activation of multiple genes, which may subsequently result in the expression of leukemia-associated antigens. In this study, we investigated the immunogenicity of Bcr-Abl–regulated antigens by stimulating CD8+ T lymphocytes with autologous ...
Florian, Scheich, Justus, Duyster, Christian, Peschel, Helga, Bernhard   +3 more
openaire   +2 more sources

?????????????? ??'?????????? ???????????? ???????? bcr/abl ?????? ???????????????? ???????????????????????????? ?????????????? ?? ???????????????????????????????? ????????????????????

2019
???????????????????????? 3???8 ?????????????? ???????????????????? ???????? bcr/abl ?????????????????? ?????????????? ?????????????? ??'?????????? ???????????? (108 ??????????????????????) ?? ?????????????? ???? ?????????????? ?????????????????????????? ???????????? ?? ???????????????? ?? ?????????????? M-bcr. ???????????????????????????? ???????? ?????
openaire   +3 more sources

BCR/ABL signal transduction.

International journal of hematology, 1995
A strong association between the Philadelphia chromosome (Ph1) and chronic myelogenous leukemia (CML) suggests that the Ph1 translocation plays a significant role in pathogenesis of CML. For this reason, Ph1-positive leukemias have been well studied from the molecular, clinical and cell biological perspective.
T, Tauchi, H E, Broxmeyer
openaire   +1 more source

Bcr-Abl Kinase Inhibitors

2006
The hallmark of chronic myelogenous leukemia (CML) is the expression of Bcr-Abl, a constitutivelyactive form of the Abl tyrosine kinase. Imatinib, a 2-phenyl aminopyrimidine Bcr-Abl inhibitor developedby Novartis and marketed under the tradename of Gleevec (Glivec), is highly effective in treating CML patientswith early stage disease. However, patients
openaire   +1 more source